Statistics seminar

​Konstantinos Konstantinou, Chalmers/GU: "Spatial modeling of epidermal nerve fiber patterns"

Abstract:  Peripheral neuropathy is a condition associated with poor nerve functionality. Epidermal nerve fiber (ENF) counts per epidermal surface are dramatically reduced and the two dimensional spatial structure of ENFs tends to become more clustered as neuropathy progresses. Therefore, studying the spatial structure of ENFs is essential to fully understand the mechanisms that guide those morphological changes. In this paper, we compare ENF patterns of healthy controls and subjects suffering from mild diabetic neuropathy by using suction skin blister specimens obtained from the right foot. Previous analysis of these data has focused on the analysis and modelling of the spatial ENF patterns consisting of the points where the nerves enter the epidermis, base points, and the points where the nerve fibers terminate, end points, projected on a two dimensional plane, regarding the patterns as realisations of spatial point processes. Here, we include the first branching points, the points where the nerve trees branch for the first time, and model the three dimensional patterns consisting of these three types of points. To analyze the patterns, spatial summary statistics are used and a new epidermal active territory (EAT) that measures the volume in the epidermis that is covered by the individual nerve fibers is constructed. We developed a model for both the two dimensional and the three dimensional patterns including the  branching points. Also, possible competitive behavior between individual nerves is examined. Our results indicate that changes in the ENFs spatial structure can more easily be detected in the later parts of the ENFs.

See Konstantinou, K., & Särkkä, A. (2021). Spatial modeling of epidermal nerve fiber patterns. Statistics in Medicine https://doi.org/10.1002/sim.9194

​​The seminar will take place in the room PASCAL and also on zoom https://chalmers.zoom.us/j/63763813811 (a password is needed: email picchini@chalmers.se)

Physical attendance in Pascal is much appreciated.
Kategori Seminarium
Plats: Pascal and online
Tid: 2021-10-12 14:15
Sluttid: 2021-10-12 15:15

Sidansvarig Publicerad: to 07 okt 2021.