Type 1 diabetes and celiac disease are two of the most common autoimmune diseases in children and the incidence of these diseases are high in Sweden. We work with translational immunology i.e., our research includes studies of immunological mechanisms and tools for prevention, diagnosis, and treatment of autoimmune diseases especially in children with type 1 diabetes and/or celiac disease.
Study biomarkers for autoimmune diseases
We are working with ex vivo and in vitro models to study extra- and intracellular biomarkers relevant for these autoimmune diseases. A wide range of biomarkers to characterizes e.g., T- and B-cells and their respective subgroups including also regulatory immune cells (both Treg and Breg) as well as cytokines and chemokines are included in our panel of studied biomarkers.
Frontline of immunological methodology
The techniques used are in the frontline of immunological methodology and we put a great effort to build up techniques useable for studying peripheral blood mononuclear cells in clinical cohorts. The methods used are e g flow cytometry and multiplex luminescence techniques which preferable can be used for studying also other immunological diseases in both children and adults.