Research leader: Nathalie Scheers
Our research focus is within the area of molecular nutrition. We are interested in effects on health and disease from specific metal compounds, proteins or other molecules that we absorb from the diet or ingest by supplementation. The goal is to understand cellular mechanisms on the intestinal level and to understand the association/correlation between intake of specific nutrients and disease - to prevent disease.
In this unit we are mainly working with human cell models. It can be single cultures or co-culture models of intestinal cells with hepatocytes or mucus-producing goblet cells. We investigate regulation of uptake proteins, stress response and apoptosis, expression of cancer and inflammation markers, and bioavailability of nutrients - all depending on the research question. In addition to the core activities there are also other interests in the unit e.g. we have previously identified a molecule that interferes with transglutaminase processing of gluten, important for driving celiac disease, which we are now further evaluating in a human intervention study started this fall (2020). Another hot topic in the unit is the fish protein parvalbumin beta, which have been observed to prevent amyloid formation of the Parkinson´s protein in vitro. We will further investigate the role of fish-specific parvalbumin beta as a neuronal protector. One of the questions is, if intake of fish rich in Parvalbumin beta, is negatively associated with Alzheimer’s disease or other diseases affecting neuronal survival (leading to cognitive decline).
Postdoc position available:
We are looking for a 1-year postdoc, starting in January 2022. The work will involve culturing of human intestinal tissue cultures, primary epithelial cell lines, and involvement in a single meal study in celiac patients. You need to be flexible and prepared for fast changes in work tasks, which may involve that you need to pick up tissue samples at the local hospital on short notice or that you need to adapt to the intervention partcipants needs. You must be proficient in culturing of human primary epithelial cells and running ELISA assays in addition to other moelcular biological methods. A human biology/medical background is needed. If you are interested, write an email to Nathalie Scheers.
Associate professor Nathalie Scheers
Ph.D student Agata Tarczykowska
Former team members:
Postdoc Darja dobermann
Postdoc Niklas Engstöm
Visiting Ph.D. student Fionn O’fearghail
Nutrician/project assistant Hanna Öhrn
(Wheat for everyone-study)
Dietician Dr. Lena Böhn (Wheat for everyone-study)