Ann-Sofie Sandbergs´research has focus on three areas:
1) The influence of early life nutrition on shaping the immune system and maturation of physiological immune tolerance with focus on allergy prevention. The goal is to find novel strategies for prevention and prediction of allergy. Allergic disease is a major problem in Western society in particular, and the most common chronic disease among children in Sweden. There is currently no evidence-based strategy to reduce the risk of allergy.We work in two prospective mother child birth cohorts NICE and FARMFLORA. NICE: The overall aim is to study how the environment – nutrition, microbes, and environmental toxins - during pregnancy and the first years of life influence maturation of the immune system and development of immune mediated and neurological diseases (biobank, multiomics methods). FARMFLORA: To identify factors (diet and nutrients, gut and airway microbiota) that may be part of the allergy protection of the farming environment.
2) Marine food bioactive compounds and ingredients and their mode of action in relation to metabolic disease. A protein shift from meat to fish or plant based protein is investigated from nutrional and health aspects. The goal is to identify marine bioactive compounds that reduce the disease risk and unravel their mechanism of action. Furthermore healthy and sustainable fish and plant proteins will be developed. Fish intake is in epidemiological studies associated with a long life in good health, but it is not known which factors in fish that are exerting the effects and the mechanisms behind. We perform dietary intervention studies in humans and in mice applying a systems biology approach to investigate mechanisms.
3) Iron and zinc nutrition, including iron biofortification, fermentation and iron speciation in relation to bioavailability. The goal is means to improve iron status in vulnerable groups and prevent iron deficiency. Micronutrient deficiencies affect a large part of the developing world´s population; iron and zinc deficiency being two of the most important. Plant based diets contain non-haem iron which generally has low bioavailability due to the content of inhibitors (phytate, polyphenols).Our studies are performed in cell models and in human interventions.
Collaborations: Systems Biology Chalmers, Sahlgrenska Academy, Sunderby Hospital, Karolinska Institute, Umeå University, University of Copenhagen, Nestlé Research Centre, AgResearch New Zeeland.
Malin Barman, forskare
Karin Jonsson, Dr
Swarnim Gupta Postdoc
Mia Andersson Dietist
Olle Hartvigsson, doktorand
Cecilia Mayer Labba, doktorand
Elin Johansson, Masterstudent
Markus Suokko Masterstudent
Cecilia Lindskog Masterstudent