Events: Bioteknik events at Chalmers University of TechnologyTue, 19 Mar 2019 14:31:01 +0100 Health 2019<p>Wallenbergsalen, lecture hall,</p><p>​What will the future of healthcare bring? How do we take advantage of the endless possibilities of new technology? And what skills will be desired? This conference aims to inspire new research collaborations and new career tracks of the future of healthcare.</p><div><br /></div> <div><span>Join this event to take part of a line up of speakers presenting exciting research collaborations between Chalmers and Sahlgrenska University Hospital/Sahlgrenska Academy and learn how to be successful in the health engineering area.</span><span><br /></span></div> <div><span><br /></span></div> <div><span>During the two days, researchers, students, clinicians and companies within life science meet to network and explore new research collaborations and new career tracks of future healthcare. </span>This conference is free of charge and mainly for those who are studying or researching in the field of life sciences in west Sweden.</div> <div><br /></div> <div>Note that the conference will mostly be held in English. Panel discussions may be held in Swedish. <span><br /></span></div> <div><span><br /></span></div> <div><span>Engineering Health is a joint event organized by Chalmers University of Technology, Sahlgrenska University Hospital and Sahlgrenska Academy, to bring medicine and engineering closer together.</span> The conference is held for the second year in a row. This year's host is Sahlgrenska University Hospital.</div> <div><span style="display:inline-block"></span><span>​<span style="display:inline-block"></span></span><br /><span><span style="display:inline-block"></span></span><a href="">&gt;&gt; See full program and REGISTER HERE<br /></a></div> <div><a href=""><br /></a></div> <div><em>Register no later than 13 March</em><br /></div> Babaei, System and Synthetic Biology<p>Lecture Hall KA, Chemistry Building</p><p>​“In silico analysis of the human gut microbiota through metabolic modelling and community simulation”</p>​<br />Opponent:       Prof. Bas Tuesink, Vrije University Amsterdam<br /><br />Supervisor:      Prof. Jens B. Nielsen, Chalmers<br />Examiner:        Prof. Ivan Mijakovic, Chalmers Sánchez, Systems & Synthetic Biology<p>Lecture Hall KA, Chemistry Building</p><p>​“Computing abundance constraints in Saccharomyces cerevisiae’s metabolism”</p>​<br />Opponent: Prof. Markus Herrgård, Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, Lyngby<br /><br />Supervisor: Prof. Jens B. Nielsen, Chalmers<br /><div>Examiner: Prof. Stefan Hohmann, Chalmers </div> <div><br /></div> <div><strong>Abstract</strong><br /><br />Biotechnology, the exploitation of biological processes for the benefit of humanity, has become one of the main industries in our current economy. A big part of biotechnology relies on understanding biological microorganisms and how to tune them to best suit the corresponding applications. Metabolism, the interplay of biochemical reactions inside a cell to generate energy and components needed for growth, is an important layer of information for understanding microorganisms. In this thesis, I study metabolism of <em>Saccharomyces cerevisiae</em> (budding yeast), one of the most popular microorganisms in biotechnology, used for the production of bread, beer, wine, biofuels and many other biotechnology products.<br /><br />As metabolism is very complex, the best way to study it is with the aid of computers. A common approach for doing this is by creating what is known as a genome-scale metabolic model (GEM), which is a mathematical representation of all reactions in metabolism. A problem that this method has is that it lacks information to be able to computationally simulate biological responses under certain experimental conditions. Important information that could be added are the abundances inside the cell of different biomolecules, such as lipids and proteins. In this thesis, I present methods for improving computational simulations of GEMs with so-called “abundance constraints”, together with novel observations about yeast biology. <br /><br />Among the computational methods, I present i) a way of storing and updating GEMs so we keep track of every change we do; ii) a method for combining GEMs with intracellular levels of lipids; iii) a method for combining GEMs with enzymes, which are proteins that can catalyze metabolic reactions; and iv) an improved method for estimating protein levels based on experimental data.<br /><br />Among other results, I show that i) lipid metabolism is very flexible, meaning that yeast is able to re-arrange it in different ways without spending too much energy; ii) the total enzyme content in yeast imposes an important constraint on metabolism, as the cell will be limited to certain options based on the amount of available enzyme; iii) specifically, when yeast has to grow fast, it will have to become less efficient in processing substrate; and iv) specific enzyme levels can create limitations in metabolism when the cell is grown under an environmental stress.<br /><br />The results presented in this thesis show that by accounting for extra levels of information, computational approaches can be improved to better understand biology. Furthermore, the methods developed are expected to be useful for industrial applications of <em>S. cerevisiae</em>, as tools for guiding researchers to develop new strains with improved performance.<br /><br /></div> Way Seminar: Kia Nöhr Iversen, Food & Nutrition Science<p>Utsikten, room 7033, 7th floor, Chemistry Building</p><p>​“The effect of cereals on body weight and body fat – the role of satiety and gut microbiota”</p>​<br />Supervisor: Professor Rikard Landberg<br />Examiner: Prof. Ann-Sofie Sandberg & Technology Day 2019<p>Kemi, university building, Kemi, Campus Johanneberg</p><p>Find all information about this day on the Science &amp; Technology Day web page!​</p> on Modelling in Biology and Medicine<p>Wallenberg Conference Centre, Medicinaregatan 20A</p><p>​We want to bring together young researchers in Sweden working on the border of math, biology, and medicine</p>​<br />We aim to gather all young researchers in Sweden working on modelling of biological systems. Our ambition is to give all participating PhD students and PostDocs the opportunity to present their work through an oral presentation or a poster. Further, we wish to provide an insight on how modelling in biology and medicine is practised in academia and industry. Das, Systems & Synthetic Biology<p>KC, lecture hall, Kemigården 4, Kemi</p><p>​“Mining human gut microbial metabolism through in vitro and in silico approaches”</p>​<br />Opponent: Prof. Susanne Brix Pedersen, Technical University of Denmark (DTU)<br /><br />Supervisor: Prof. Jens B Nielsen, Chalmers<br />Examiner: Prof. Ivan Mijakovic, Chalmers Skoog, Industrial Biotechnology<p>KA, lecture hall, Kemigården 4, Kemi</p><p>​​“Biobased adipic acid production – challenges when establishing the cell factory”</p>​<br />Faculty opponent: PhD John Morrisey, School of Microbiology, University College Cork, Ireland<br /><br />Supervisor: Prof. Lisbeth Olsson, Chalmers<br /><div>Examiner: Associate Professor Carl Johan Franzén, Chalmers</div> <br /> Bergman, Systems & Synthetic Biology<p>KA, lecture hall, Kemigården 4, Kemi</p><p>​“Evaluation of precursor and cofactor engineering strategies influencing fatty acid metabolism in Saccharomyces cerevisiae”</p>​<br />Opponent: Prof. Antonius van Maris, Royal Institute of Technology, Stockholm<br /><br />Supervisor: Prof. Jens B Nielsen, Chalmers<br />Examiner: Associate Prof. Dina Petranovic, Chalmers International Conference on Yeast Genetics and Molecular Biology<p>TBA</p><p>​Gothenburg, 18-22 August 2019</p><p>​<br />Five days of exciting and novel yeast themes!<br />The “International Yeast Conferences” started in the 1960s with a handful of delegates and since then have become THE most important event in yeast research. Now the yeast meeting returns to Gothenburg, Sweden.</p> <p>Details and program: <a href=""></a></p>