Speaker: William H. Gerwick
Affiliation: Scripps Institution of Oceanography, Skaggs School of Pharmacy and Pharmaceutical Science, University of California San Diego
“Marine cyanobacteria have been one of the richest marine sources of novel and highly bioactive natural products. For the most part, they derive from the assembly of amino acids via the non-ribosomal peptide synthetase pathway, acetate units from the polyketide synthase pathway, and the inter-digitation of these two pathways to form ‘hybrid’ natural products. Our recent genome sequencing projects of marine cyanobacteria have revealed that some strains allocate over 20% of their genome to natural products biosynthesis, and have the capacity to produce up to 45 different classes of secondary metabolites. Mass spectrometry-based molecular networking along with AI-trained NMR databases are providing powerful methods by which to rapidly identify natural products in our collection and connect these to their biosynthetic gene clusters. While the metabolites of marine cyanobacteria possess diverse biological properties, many are toxic to cells and therefore have potential applications in cancer and parasitic diseases. In this regard, we discovered two classes of lipopeptides from Caribbean marine cyanobacteria that have exquisite potency to cancer cells and various classes of parasites. For each of these, we crafted total syntheses that are allowing access to insightful analogs, some of which have improved potency and selectivity. Hence, a diversity of tools are being used to discover and explore the biotechnological and pharmaceutical value of these marine metabolites.”
Due to changes in the Swedish Tax Agency's rules regarding food benefits, we will only be able to serve a small fika, first come first served.
The Life Science Monday Seminars will display the wide range of
Life Science activities in the Gothenburg region, but we will also have speakers from abroad.
Academia, research institutes, and industry will be represented.
It is our goal to increase the interaction between education, research, and
innovation in order to make the Life Science environment at Chalmers more dynamic.