News: Livsvetenskaper och teknik related to Chalmers University of TechnologyMon, 28 Nov 2022 15:56:37 +0100 tailors DNA for future drug development<p><b>​With the help of an AI, researchers at Chalmers University of Technology have succeeded in designing synthetic DNA that controls the cells' protein production.  The technology can contribute to the development and production of vaccines, drugs for severe diseases, as well as alternative food proteins much faster and at significantly lower costs than today. ​</b></p><div>​<span style="background-color:initial">How our genes are expressed is a process that is fundamental to the functionality of cells in all living organisms. Simply put, the genetic code in DNA is transcribed to the molecule messenger RNA (mRNA), which tells the cell's factory which protein to produce and in which quantities.</span></div> <div>Researchers have put a lot of effort into trying to control gene expression because it can, among other things, contribute to the development of protein-based drugs. A recent example is the mRNA vaccine against Covid-19, which instructed the body's cells to produce the same protein found on the surface of the coronavirus. The body's immune system could then learn to form antibodies against the virus. Likewise, it is possible to teach the body's immune system to defeat cancer cells or other complex diseases if one understands the genetic code behind the production of specific proteins. </div> <div> </div> <h2 class="chalmersElement-H2">&quot;The DNA controls the quantity of a specific protein&quot;</h2> <div> </div> <div><img src="/SiteCollectionImages/Institutioner/Bio/SysBio/Aleksej%20Zelezniak.jpg" alt="Aleksej Zelezniak" class="chalmersPosition-FloatRight" style="margin:5px 15px" />Most of today's new drugs are protein-based, but the techniques for producing them are both expensive and slow, because it is difficult to control how the DNA is expressed.  Last year, a research group at Chalmers, led by <strong>Aleksej Zelezniak,</strong> Associate Professor of Systems Biology, took an important step in understanding and controlling how much of a protein is made from a certain DNA sequence.</div> <div> </div> <div>&quot;First it was about being able to fully ‘read’ the DNA molecule's instructions. Now we have succeeded in designing our own DNA that contains the exact instructions to control the quantity of a specific protein&quot;, says Aleksej Zelezniak about the research group's latest important breakthrough. </div> <div> </div> <h2 class="chalmersElement-H2">DNA molecules made-to-order</h2> <div> </div> <div>The principle behind the new method is similar to when an AI generates faces that look like real people. By learning what a large selection of faces looks like, the AI can then create completely new but natural-looking faces. It is then easy to modify a face by, for example, saying that it should look older, or have a different hairstyle. On the other hand, programming a believable face from scratch, without the use of AI, would have been much more difficult and time-consuming. Similarly, the researchers' AI has been taught the structure and regulatory code of DNA. The AI then designs synthetic DNA, where it is easy to modify its regulatory information in the desired direction of gene expression. </div> <div> </div> <div>Simply put, the AI is told how much of a gene is desired and then  ‘prints’ the appropriate DNA sequence. </div> <div> </div> <div><img src="/SiteCollectionImages/Institutioner/Bio/SysBio/Jan%20Zrimec_200%20px.jpg" alt="Jan Zrimec" class="chalmersPosition-FloatRight" style="margin:5px 15px" />“DNA is an incredibly long and complex molecule. It is thus experimentally extremely challenging to make changes to it by iteratively reading and changing it, then reading and changing it again. This way it takes years of research to find something that works. Instead, it is much more effective to let an AI learn the principles of navigating DNA. What otherwise takes years is now shortened to weeks or days”, says first author <strong>Jan Zrimec</strong>, a research associate at the National Institute of Biology in Slovenia and past postdoc in Aleksej Zelezniak’s group.</div> <div> </div> <h2 class="chalmersElement-H2"></h2> <h2 class="chalmersElement-H2">Efficiant development of proteins<span></span></h2> <p class="chalmersElement-P">The researchers have developed their method in the yeast <em>Saccharomyces cerevisiae</em><span>, whose cells resemble mammalian cells. The next step is to use human cells. The researchers have hopes that their progress will have an impact on the development of new as well as existing drugs.</span></p> <div> </div> <div>&quot;Protein-based drugs for complex diseases or alternative sustainable food proteins can take many years and can be extremely expensive to develop. Some are so expensive that it is impossible to obtain a return on investment, making them economically nonviable. With our technology, it is possible to develop and manufacture proteins much more efficiently so that they can be marketed&quot;, says Aleksej Zelezniak.</div> <div> </div> <div><strong>Text: </strong>Karin Wik<br /><strong>Illustration: </strong>Unsplash &amp; Pixabay</div> <div> </div> <div><br /></div> <div> </div> <div><strong>Read the study:</strong> <span style="background-color:initial"><a href="">Controlling gene expression with deep generative design of regulatory DNA</a></span></div> <div> </div> <div><ul><li><span style="background-color:initial">T</span><span style="background-color:initial">he authors of the study are Jan Zrimec, Xiaozhi Fu, Azam Sheikh Muhammad, Christos Skrekas, Vykintas </span><span style="background-color:initial">Ja</span><span style="background-color:initial">uniskis</span><span style="background-color:initial"></span><span style="background-color:initial"></span><span style="background-color:initial"></span><span style="background-color:initial">, N</span><span style="background-color:initial">ora K. Speicher, Christoph S. Börlin, Vilhelm Verendel, Morteza Haghir Chehreghani, Devdatt Dubhashi, Verena Siewers, Florian David, Jens Nielsen and Aleksej Zelezniak.</span></li> <li><span style="background-color:initial"></span>The researc<span style="background-color:initial">her are active at Chalmers University of Technology,  National Institute of Biology, Slovenia; Biomatter Designs, Lithuania; Institute of Biotechnology, Lithuania; BioInnovation Institute, Denmark; King’s College London, UK.</span></li></ul></div> <div> </div> <div><strong>For more information, please contact:</strong> </div> <div> </div> <div><a href="/en/Staff/Pages/alezel.aspx">Aleksej Zelezniak</a>, Associate Professor, Department of Biology and Biological Engineering, Chalmers University of Technology, +46 31 772 81 71,</div> <div> </div> <div><br /></div> <div> </div> <div><br /></div> <div> </div> <div></div> <div> </div> <div>​<br /></div> <div> </div> ​Thu, 24 Nov 2022 07:00:00 +0100 discovery gives hope to fight metastatic cancer<p><b>​Cancer that splits and develops in new organs around the body becomes significantly more difficult to fight. Now, researchers at Chalmers have shown that these metastatic cancers, that spread from the original, adapt their metabolism to the tissue in which they grow. The discovery represents a breakthrough for the understanding of metastatic cancer and is an important piece of the puzzle in the search for more effective treatments.</b></p><p class="chalmersElement-P">​<span>Metabolism in the human body can be likened to its internal engine.  It is a prerequisite for our cells to grow and receive energy.  Therefore, it is also an important target for cancer treatments, where the focus is on stopping the progress of cancer cells.</span></p> <div> </div> <p class="chalmersElement-P"> </p> <div> </div> <p class="chalmersElement-P">In <a href="">a new study</a>, which was recently presented in the scientific journal PNAS, researchers in Systems and Synthetic Biology at Chalmers have examined how metabolism works in cancer cells that have spread via metastases – also called secondary tumors – to new organs. The study gave the researchers new insights into how the metastases adapt to their new environment.</p> <div> </div> <p class="chalmersElement-P"> </p> <div> </div> <p class="chalmersElement-P"> </p> <div> </div> <p class="chalmersElement-P"> </p> <div> </div> <p class="chalmersElement-P"><img src="/SiteCollectionImages/Institutioner/Bio/SysBio/FaribaRoshanzamir_350x305.jpg" alt="Fariba Roshanzamir" class="chalmersPosition-FloatRight" style="margin:5px 10px;width:250px;height:218px" />&quot;Obviously, the local environment affects the cancer cells more than previously known.  The metastatic tumours should show the same metabolic properties no matter where in the body they are located, but we discovered that the cancer cells largely adapted their metabolism to the new tissue in order to continue to develop and grow. This is important knowledge, which shows that we cannot consider the metastases as their original tumors,&quot; says <strong>Fariba Roshanzamir</strong>, PhD in Systems and Synthetic Biology at Chalmers and the study's lead author.</p> <div> </div> <p class="chalmersElement-P"> </p> <div> </div> <p class="chalmersElement-P"> </p> <div> </div> <p class="chalmersElement-P"> </p> <div> </div> <h2 class="chalmersElement-H2">Tools for inhibiting cancer metabolism</h2> <h2 class="chalmersElement-H2"> </h2> <h2 class="chalmersElement-H2"> </h2> <h2 class="chalmersElement-H2"> </h2> <h2 class="chalmersElement-H2"> </h2> <h2 class="chalmersElement-H2"> </h2> <h2 class="chalmersElement-H2"> </h2> <h2 class="chalmersElement-H2"> </h2> <p class="chalmersElement-P">Fariba Roshanzamir works in Professor Jens Nielsen's research group at Chalmers and has, together with Swedish and international colleagues, been able to establish the groundbreaking results. The study focused primarily on so-called triple-negative breast cancer – a severe breast cancer that is difficult to treat with drugs – but the conclusions can, according to the researchers, be applied to all types of metastatic cancer. This opens new doors to develop more effective treatments. </p> <div> </div> <p class="chalmersElement-P"> </p> <div> </div> <p class="chalmersElement-P"> </p> <div> </div> <p class="chalmersElement-P"> </p> <div> </div> <p class="chalmersElement-P">&quot;If we manage to shut down the metabolism in a tumour, it will stop working and this study provides important keys to better understand what to target. Selecting metabolic inhibitors that specifically target the metastases in the organs to which the tumour has spread, rather than treating them as their original tumours, is of great importance to be able to find good strategies for treatments in the future,&quot; she says.</p> <div> </div> <p class="chalmersElement-P"> </p> <div> </div> <p class="chalmersElement-P"> </p> <div> </div> <p class="chalmersElement-P"> </p> <div> </div> <h2 class="chalmersElement-H2">New view of the properties of metastases</h2> <div> </div> <p class="chalmersElement-P"> </p> <div> </div> <p class="chalmersElement-P"> </p> <div> </div> <p class="chalmersElement-P"> </p> <div> </div> <p class="chalmersElement-P"><img src="/SiteCollectionImages/Institutioner/Bio/SysBio/Jens%20Nielsen3-3110-350.jpg" alt="Jens Nielsen" class="chalmersPosition-FloatRight" style="margin:5px 10px;width:250px;height:218px" />Today, the spread of cancer to new organs is one of the leading causes of death in cancer patients. <strong> Jens Nielsen</strong>, Professor of Systems and Synthetic Biology, and one of the study's authors, hopes that it will lead to a new view of the properties and behavior of metastases.  </p> <div> </div> <p class="chalmersElement-P"> </p> <div> </div> <p class="chalmersElement-P"> </p> <div> </div> <p class="chalmersElement-P"> </p> <div> </div> <p class="chalmersElement-P">&quot;This is a breakthrough in terms of our understanding of metastatic cancer and an important step on the way to more individualised drugs,&quot; he says.</p> <p class="chalmersElement-P"><span style="font-weight:700">Text:</span> Ulrika Ernström<br /></p> <div> </div> <p class="chalmersElement-P"> </p> <div> </div> <p class="chalmersElement-P"> </p> <div> </div> <p class="chalmersElement-P"> </p> <div> </div> <p class="chalmersElement-P"><br /></p> <div> </div> <p class="chalmersElement-P"> </p> <div> </div> <p class="chalmersElement-P"> </p> <div> </div> <p class="chalmersElement-P"> </p> <div> </div> <p class="chalmersElement-P"><strong>Read the article</strong> <a href="">&quot;Metastatic triple negative breast cancer adapts its metabolism to destination tissues while retaining key metabolic signatures&quot;</a> published in the scientific journal PNAS. </p> <div> </div> <p class="chalmersElement-P"> </p> <div> </div> <p class="chalmersElement-P"> </p> <div> </div> <p class="chalmersElement-P"> </p> <div> </div> <p class="chalmersElement-P"></p> <ul><li>The authors are Fariba Roshanzamir, Chalmers and University of Tehran, Jonathan L. Robinson, Chalmers, Daniel Cook, Chalmers, Mohammad Hossein Karimi-Jafari, University of Tehran and Jens Nielsen, Chalmers.</li> <li>The research has been carried out with support from the Knut and Alice Wallenberg Foundation.</li></ul> <p></p> <div> </div> <p class="chalmersElement-P"> </p> <div> </div> <p class="chalmersElement-P"> </p> <div> </div> <p class="chalmersElement-P"> </p> <div> </div> <div> </div> <p class="chalmersElement-P"> </p> <div> </div> <p class="chalmersElement-P"> </p> <div> </div> <p class="chalmersElement-P"> </p> <div> </div> <p class="chalmersElement-P"><strong>More about the research</strong></p> <strong> </strong><div><strong> </strong></div> <strong> </strong><p class="chalmersElement-P"><strong> </strong></p> <strong> </strong><div><strong> </strong></div> <strong> </strong><p class="chalmersElement-P"><strong> </strong></p> <strong> </strong><div><strong> </strong></div> <strong> </strong><p class="chalmersElement-P"><strong> </strong></p> <strong> </strong><div><strong> </strong></div> <strong> </strong><p class="chalmersElement-P"></p> <ul><li>The study examined metastatic tumors (also called secondary tumours) in mainly lungs, brain, and liver from triple-negative breast cancer as well as skin cancer (a smaller part). </li> <li>The researchers found that the metabolism of the metastatic cancer cells largely adapted to the tissue of the organ in which they grew. </li> <li>The adaptation varied in scope between different organs and the metastatic tumours retained certain metabolic characteristics associated with the original tumours. </li></ul> <p></p> <div> </div> <p class="chalmersElement-P"> </p> <div> </div> <p class="chalmersElement-P"> </p> <div> </div> <p class="chalmersElement-P"> </p> <div> </div> <p class="chalmersElement-P"><strong>For more information, please contact:</strong></p> <div> </div> <p class="chalmersElement-P"> </p> <div> </div> <p class="chalmersElement-P"> </p> <div> </div> <p class="chalmersElement-P"> </p> <div> </div> <p class="chalmersElement-P"><a href="/en/staff/Pages/faribar.aspx">Fariba Roshanzamir</a>, PhD, Department of Biology and Biological Engineering, Chalmers, 076 <span style="background-color:initial">054 7653, </span><a href=""></a></p> <div> </div> <p class="chalmersElement-P"> </p> <div> </div> <p class="chalmersElement-P"> </p> <div> </div> <p class="chalmersElement-P"> </p> <div> </div> <p class="chalmersElement-P"><a href="/en/Staff/Pages/Jens-B-Nielsen.aspx">Jens Nielsen​</a>, Professor, Department of Biology and Biological Engineering, Chalmers , 031 772 38 04, <span style="background-color:initial"><a href="">​​</a></span></p> <div> </div> <p class="chalmersElement-P"> </p> <div> </div> <p class="chalmersElement-P"> </p> <div> </div> <p class="chalmersElement-P"> </p> <div> </div> <p class="chalmersElement-P"><br /></p> <div> </div> <p class="chalmersElement-P"> </p> <div> </div> <p class="chalmersElement-P"> </p>Thu, 17 Nov 2022 07:00:00 +0100 a clue in the fight against cancer<p><b>​For cancer cells to grow and spread around the human body, they need proteins that bind copper ions. New research about how cancer-related proteins bind the metal and how they interact with other proteins, opens up potential new drug targets in the fight against cancer. ​</b></p><div><span style="color:rgb(33, 33, 33);background-color:initial">​</span><span style="color:rgb(33, 33, 33);background-color:initial">Human cells need small amounts of the metal copper to be able to carry out vital biological processes. Studies have shown that the level of copper in tumour cells and blood serum from cancer patients is elevated, and the conclusion is that cancer cells need more copper than healthy cells. Higher levels of copper also mean more active copper-binding proteins. </span><br /></div> <p class="chalmersElement-P"></p> <p class="chalmersElement-P"> </p> <p class="chalmersElement-P"><img src="/SiteCollectionImages/Institutioner/Bio/ChemBio/PernillaWittung-Stafshede_professor_01_350.jpg" alt="Pernilla Wittung-Stafshede" class="chalmersPosition-FloatRight" style="margin:5px 10px;width:250px;height:218px" />&quot;Therefore, these proteins are highly important to study when it comes to understanding the development of cancer and deeper knowledge about them can lead to new targets for treatment of the disease,&quot; says <strong>Pernilla Wittung-Stafshede</strong>, Professor of Chemical Biology at Chalmers. </p> <p class="chalmersElement-P"><span>Most cancer-related deaths are due to the fact that metastases − secondary tumours − form in several places in the body, for example, in the liver or lungs. A protein called Memo1 is part of the signaling systems that cancer cells use to grow and spread around the body. Previous research has shown that when the gene for Memo1 is inactivated in breast cancer cells, their ability to form metastases decreases.</span></p> <h2 class="chalmersElement-H2"><span>Memo1 blocks toxic redox reactions​</span></h2> <p class="chalmersElement-P"> </p> <p class="chalmersElement-P"> </p> <p class="chalmersElement-P"> </p> <p class="chalmersElement-P">A research group from Chalmers wanted to take a closer look at the connection between Memo1 and copper. In<a href=""> a new study published in the scientific journal PNAS</a>, the researchers examined the Memo1 protein's ability to bind copper ions through a series of test tube experiments. </p> <p class="chalmersElement-P">They discovered that the protein binds copper, but only the reduced form of copper. It is this form of copper ions that is most common in living cells. It's an important discovery because reduced copper, while it is needed in the body, also contributes to redox-reactions that damage − or even kill −​ the cells. The researchers found that when Memo1 interacted with copper, the metal's toxic redox reactions were blocked. </p> <p class="chalmersElement-P"> </p> <p class="chalmersElement-P"> </p> <p class="chalmersElement-P"> </p> <p class="chalmersElement-P">&quot;This poses a risk for the tumour to be dependent on a lot of copper because it can provoke chemical reactions that are harmful to the cancer cells. We believe that Memo1, by binding copper when needed, protects the cancer cells so that they can continue to live and spread,&quot; says Pernilla Wittung-Stafshede, who is one of the study's lead authors.</p> <h2 class="chalmersElement-H2">Memo1 forms complex with copper transporter Atox1</h2> <p class="chalmersElement-P"> </p> <p class="chalmersElement-P"> </p> <p class="chalmersElement-P"> </p> <p class="chalmersElement-P">The researchers also saw that Memo1 can form a complex with another copper-binding protein found in our cells – Atox1. It is a copper transporter inside human cells and the research team has previously shown that Atox1, with the help of copper, contributes to breast cancer cells being able to move and form metastases. Overall, the findings in the new study mean that copper and copper-binding proteins could be targets for future cancer treatment. </p> <p class="chalmersElement-P"> </p> <p class="chalmersElement-P"> </p> <p class="chalmersElement-P"> </p> <p class="chalmersElement-P">&quot;We saw how copper ions could transfer between the proteins Memo1 and Atox1 in test tubes, and when we looked in breast cancer cells, we found that the two proteins were close to each other in space.  Based on this, we conclude that the exchange of copper between these proteins can take place in cancer cells as well as in test tubes and thus be of biological relevance,&quot; says Pernilla Wittung-Stafshede. </p> <p class="chalmersElement-P"><span style="background-color:initial">​</span><span style="background-color:initial">The researchers now want to move forward with determining the copper ion binding sites in Memo1, and how the presence of copper affects Memo1’s activities in cancer development.</span></p> <p class="chalmersElement-P"> </p> <p class="chalmersElement-P"> </p> <p class="chalmersElement-P"> </p> <p class="chalmersElement-P">&quot;When we expand our basic knowledge of the role of copper-binding proteins in cancer cells, we also open the door to new treatments,&quot; says Pernilla Wittung-Stafshede. </p> <p class="chalmersElement-P"><strong>Text:</strong> Susanne Nilsson Lindh and Karin Wik</p> <p class="chalmersElement-P"> </p> <p class="chalmersElement-P"> </p> <p class="chalmersElement-P"> </p> <p class="chalmersElement-P"><br /></p> <p class="chalmersElement-P"> </p> <p class="chalmersElement-P"> </p> <p class="chalmersElement-P"> </p> <p class="chalmersElement-P"><strong>Read the scientific publication in PNAS: </strong><a href="">Memo1 binds reduced copper ions, interacts with copper chaperone Atox1, and protects against copper-mediated redox activity in vitro</a></p> <p class="chalmersElement-P"> </p> <p class="chalmersElement-P"> </p> <p class="chalmersElement-P"> </p> <p class="chalmersElement-P"></p> <ul><li><span style="background-color:initial">The</span><span style="background-color:initial"> article is written by Xiaolu Zhang, Gulshan R. Walke, Istvan Horvath, Ranjeet Kumar, Stéphanie Blockhuys, Stellan Hplgersson, Paul H. Walton and Pernilla Wittung Stafshede.</span></li> <li>The researchers are active at Chalmers University of Technology, the University of Gothenburg and the University of York.</li> <li><span style="background-color:initial">The study was funded </span><span style="background-color:initial">by:</span><span style="background-color:initial">C</span><span style="background-color:initial">ancerfonden</span><span style="background-color:initial"></span><span style="background-color:initial">, the Swedish Research Council and the Knut and Alice Wallenberg Foundation.</span></li></ul> <p></p> <p class="chalmersElement-P"> </p> <p class="chalmersElement-P"> </p> <p class="chalmersElement-P"> </p> <p class="chalmersElement-P"> </p> <p class="chalmersElement-P"> </p> <p class="chalmersElement-P"> </p> <p class="chalmersElement-P"><span style="background-color:initial"><b>For more information, please contact: <br /></b></span><a href="/en/staff/Pages/pernilla-wittung.aspx">Pernilla <span>Wittung-Stafshed</span><span style="background-color:initial">e</span><span style="background-color:initial"></span>​</a><span style="background-color:initial">, Professor, Department of Biology and Biological Engineering, Chalmers University of Technology, </span><a href=""></a><span style="background-color:initial">, +46 31 772 81 12</span></p> <p class="chalmersElement-P"> </p> <p class="chalmersElement-P"> </p> <p class="chalmersElement-P"> </p> <p class="chalmersElement-P"><br /></p> <p class="chalmersElement-P"> </p> <p class="chalmersElement-P"> </p> <p class="chalmersElement-P"> </p> <p class="chalmersElement-P"><strong>See also: </strong><a href="/en/departments/bio/news/Pages/Cancer-cells-spread-using-a-copper-binding-protein.aspx">Cancer cells spread using copper-binding protein</a></p> <p class="chalmersElement-P"> </p> <p class="chalmersElement-P"> </p> <p class="chalmersElement-P"> ​​​</p>Thu, 10 Nov 2022 07:00:00 +0100 new Assistant Professors with connection to health<p><b>​For the fifth time, Chalmers has made a major investment in attracting sharp research talents from all corners of the world. The campaign to recruit new Assistant Professors is now completed and the 15 new assistant professors will begin their positions at Chalmers continuously during autumn 2022/spring 2023.</b></p><div><span style="background-color:initial">Of the newly recruited, there are a total of four Assistant Professors who, with their different research orientations, have a clear connection to the health field: Annikka Polster, Eszter Lakatos, Margaret Holme and Angela Grommet.<br /><br /></span></div> <div>- It's great that Chalmers is strengthening its competence in areas of health and medicine by four of the newly recruited female Assistant Professors having connections to this area, says Ann-Sofie Cans, Director of Health Engineering Area of Advance at Chalmers.<br /></div> <div><h3 class="chalmersElement-H3">Strengthens Chalmers' position and strategic research for the future</h3> <div><span style="background-color:initial">The purpose is to strengthen Chalmers position internationally and strategically secure research for the future. This year, the interest was greater than ever before – as many as 1189 eligible applications were received. </span></div></div> <div><br /></div> <div>“It is extremely gratifying to see that the interest in Chalmers is so great internationally, and that so many research talents want to come to Chalmers to build their future career. We now all have a shared responsibility to welcome the assistant professors into our operations and invite them to conversations and collaborations,” says Anders Palmqvist, Vice President of Research.</div> <h3 class="chalmersElement-H3">Read more about the four Assistant Professors below. </h3> <div><strong><br />Annikka Polster, Health Engineering Area of Advance – Department of Biology and Biological Engineering</strong><br /><br /></div> <div>Medical Doctor, has studied genomics and systems biology<br /><br /></div> <div>PhD in Medicine from Sahlgrenska Academy, University of Gothenburg (2018).<br /><br /></div> <div>Postdoctoral student at GU in Applied Math and Statistics</div> <div><br /></div> <div>Researcher in Functional Bioinformatic at the Univerity of Örebro.<br /><br /></div> <div>Marie Sklodowska Curie Scientia Fellow, at the Nordic Center for Molecular Medicine, University of Oslo (2020-2022)<br /><br /></div> <div>Currently senior researcher at Remedy – Center for treatment of Rheumatic and Musculoskeletal Diseases, Diakonhjemmet Hospital, Oslo.<br /><br /></div> <div>“My research aims to improve our understanding of complex diseases and personalized pathophysiology. Complex diseases are difficult to treat, because patients, even with the same diagnosis, are quite different with regards to symptom severity and presentation, what comorbidities they have and how they react to treatments. My research therefore tries to identify endotypes, which are distinct pathophysiological mechanisms, and to understand how these determine individual clinical phenotypes and treatment response.”</div> <div><br /></div> <div><strong>Eszter Lakatos, Health Engineering Area of Advance – Department of Mathematical Sciences<br /><br /></strong></div> <div>MSc, infoboionics engineer, Pázmány Péter Catholic University, Budapest<br /><span style="background-color:initial"><br />PhD, theoretical systems biology, Imperial College, London<br /></span><span style="background-color:initial"><br />Post</span><span style="background-color:initial">doc, Barts Cancer Centre, London<br /></span><span style="background-color:initial"><br />Eszter Lakatos research focuses on the application of mathematical models to elucidate the behavior of complex biological systems.<br /></span><span style="background-color:initial"><br />At Chalmers, she will develop mathematical models and bioinformatic methods to analyze large-scale cancer sequencing datasets. With these methods she will ask questions about the evolution of cancers: how they interact with the immune system and how they react to therapy. Ultimately, she wants to understand how we can predict and stir cancer evolution to design better treatments.</span></div> <div><br /></div> <div><strong>Margaret Holme, Basic science – Department of Biology and Biological Engineering</strong></div> <div><br />PhD in Nanoscience (University of Basel) and MSci in Chemistry with a Year in Industry (Imperial College London).<br /><br /></div> <div>She currently holds a position as Research Coordinator at the Stevens Group, Karolinska Institutet.<br /><br /></div> <div>Awarded an SSF-funded “Future Research Leaders” grant in June 2022.<br /><br /></div> <div>“In my group we will combine knowledge in biology, chemistry and physics to study nano-particles formulated from lipids. We will characterise the composition and distribution of lipid molecules in synthetic and naturally occurring nano-particles, develop new techniques to study them (with a focus on small angle neutron and X-ray scattering), and apply our findings to design new lipid nano-particles to study and treat a range of diseases.</div> <div><br /></div> <div>I have always appreciated the collaborative and welcoming environment that Chalmers provides. This, coupled with the challenge-driven Areas of Advance, great infrastructures, plus proximity to both industry and MAX IV/ESS in Lund, makes Chalmers a really exciting place to do great science.”</div> <div><br /></div> <div><strong>Angela Grommet, Excellence Initiative Nano – Department of Chemistry and Chemical Engineering</strong></div> <div><br />PhD in Chemistry, University of Cambridge, UK<br /><br /></div> <div>Postdoc Karolinska Institute, Stockholm and Weizmann Institute of Science, Rehovot, Israel<br /><br /></div> <div>“My research focuses on using supramolecular chemistry to reduce the side-effects and improve the stability of nanotherapeutics.<br /><br /></div> <div>I chose Chalmers because the university supports and celebrates interdisciplinary research and entrepreneurship.”<br /><br /></div> <div></div>Mon, 07 Nov 2022 08:00:00 +0100 emissions when the waste-water plant catches a cold<p><b>​Autumn is here and the season for colds and flu has arrived, when viruses spread through schools, workplaces, and public spaces. But it’s not only humans that can catch a cold. A recently published paper shows that bacteria in wastewater treatment plants can also catch a cold every once in a while. </b></p>​In wastewater treatment plants, the work is often done by bacteria, who carry out biological processes used to break down the pollutants and purify the water. Like bacteria, viruses are everywhere around us, and the fact is that bacteria just like other living things can be infected by viruses. <a href="/en/Staff/Pages/oskar-modin.aspx" target="_blank">Oskar Modin</a>, Professor at the Water Environment Technology Division, Department of Architecture and Civil Engineering, has tested the thesis that a wastewater treatment plant can catch a cold.    <br /><br /> – A large treatment plant has billions of bacteria that work in a treatment process called activated sludge. <img src="/SiteCollectionImages/Institutioner/ACE/profilbilder/Oskar-Modin_170x170.jpg" class="chalmersPosition-FloatRight" alt="Oskar Modin" style="margin:5px" /><br />The bacterial communities are constantly exposed to viruses that infect them, so the question we asked ourselves was whether the process can periodically be more exposed and what happens then, says Oskar Modin.    <br /> <div><h2 class="chalmersElement-H2">Connection between virus and emissions</h2></div> Oskar and fellow researchers measured the concentration of virus particles that were released from four different wastewater treatment plants in Sweden and compared it with how much organic carbon was released at the same time.    <br /><br /> – When we measured virus particles in the water, we found a connection between viruses and organic carbon – when there were more viruses, there was also more organic carbon in the outgoing water.    <br /> <div><h2 class="chalmersElement-H2">Important to control the biologial processes </h2></div> Removal of dissolved organic carbon from wastewater is important as it would otherwise lead to increased oxygen consumption where the purified water is discharged, affecting the aquatic environment nearby. The fact that the treatment plant's smallest workers can catch a cold and as a result perform worse, is important to investigate further. Not least to be able to prevent or relieve the symptoms and thereby maximise the effectiveness of the bacteria. But tea with honey, or home remedies with ginger and lemon won’t do when it comes to bacteria.    <br /><br /> – Viruses are often specialised in a certain species, which means that humans and bacteria cannot be infected by the same virus. One possible way to influence the number of viruses in treatment plants could be to adjust the way the treatment plant is operated. We saw differences between the treatment plants in the study, which we believe may be related to the design or control of the biological treatment processes, says Oskar.    <br /><br />Researchers do not yet know exactly how the cold manifests itself in the bacteria and to what extent the virus affects the purification processes. Oskar and his colleagues continue to investigate the question in other systems where viruses and bacteria interact, and hope to look at a longer period of time and whether season, temperature and other factors have any significance.    <br /><div><br /></div> <div><h3 class="chalmersElement-H3">About the research</h3></div> The paper “<a href="" title="doi" target="_blank">A relationship between phages and organic carbon in wastewater treatment plant effluents</a>” was published in Water Research X in August 2022, and written by Oskar Modin, Nafis Fuad, Marie Abadikhah, David l’Ons, Elin Ossiansson, David J. I. Gustavsson, Ellen Edefell, Carolina Suarez, Frank Persson, Britt-Marie Wilén.  The researchers are based at Chalmers and Lund University.<br /><br /><div><em>The research project was financed by Svenskt Vatten through VA Teknik Södra and Formas, an involved wastewater treatment plants in the Swedish municipalities of Lund, Malmoe, Kalmar and Gothenburg.  <a href="" title="doi" target="_blank"></a></em></div> <div><br /></div> <div>Text: Catharina Björk<br /></div>Thu, 03 Nov 2022 00:00:00 +0100 students and healthcare managers work together on healthcare challenges<p><b>They are two very different categories of students who meet to create ideas for improvements in healthcare: managers in healthcare who are pursuing professional education at Chalmers and engineering students at master's level. By working with real cases from healthcare, the master students have been able to use their theoretical knowledge in practical applications – and at the same time given the healthcare managers valuable insights.</b></p><div>​In a joint project between Chalmers and Region Västra Götaland, two existing educations at different levels are integrated to create a cross-fertilization that can ultimately benefit patients and society. The students come from the master's programme Quality and Operations Management, while the managers in the Region Västra Götaland take a course in quality-driven operations development. The course is given by the Centre for Healthcare Improvement at Chalmers.</div> <div> </div> <div>One of the master's students who participated in the initiative is Johan Blickhammar, who has come a long way in his engineering studies. He is positive about this collaborative approach in education.<br /><br /></div> <div> </div> <div><span><span><span><span><img src="/sv/institutioner/tme/nyheter/PublishingImages/johan_blickhammar.jpg" class="chalmersPosition-FloatRight" alt="" style="margin:10px" /><span style="display:inline-block"></span></span></span></span></span>“It was exciting! Partly because of the Region Västra Götaland and the important role that healthcare plays in the society, and also that we worked with existing and upcoming challenges. It was interesting to test and apply theories to real problems and very inspiring to take part in and contribute to the region's development and improvement work.”</div> <div> </div> <div>Even in typical classes at Chalmers there is a lot of interaction between companies and students, but usually about gaining understanding and gathering knowledge about operations and methods for solving problems, says Johan. Here it was done in a more integrated way. </div> <div> </div> <div>“This initiative differed in that we students worked in collaboration and exchanged knowledge with the healthcare managers to solve present and future problems. The challenge lay mainly in the complexity that often comes with real problems, trying to identify the underlying problems and create proposals to address them in a practical, efficient, and sustainable way”, says Johan Blickhammar, and adds:</div> <div> </div> <div>“Improvement knowledge is very much about problem solving. This work has reinforced the understanding that knowledge, communication, and information are central to problem solving and improvement work.”</div> <div> </div> <h3 class="chalmersElement-H3">&quot;Contributed with approaches that we didn't think about&quot;</h3> <div> </div> <div><span><span><img src="/sv/institutioner/tme/nyheter/PublishingImages/hans_gunnarsson.jpg" class="chalmersPosition-FloatRight" alt="" style="margin:15px 10px" /><span style="display:inline-block"></span></span></span>Hans Gunnarsson is a section manager of palliative care at Högsbo Hospital, which is part of the Sahlgrenska University Hospital. From his perspective, he also sees advantages in the approach.<br /><br /></div> <div> </div> <div>“It felt like a privilege to be interviewed by the students. They contributed with approaches that I did not think about, and that were taken for granted for me. I’m now aware of the need of clarifications and  and further explanations. It is easy to think that others have the same perspectives as you, and know and can do the same things as you. So there were adequate questions, like, ’when does the process start and when does it end’? They asked many questions that made me reflect and clarify elements, activities and definitions. I thought they were veryclever and insightful.”</div> <div><br /></div> <div> </div> <div>He has also made several lessons of his own:</div> <div> </div> “In a quality improvement project like this, it is important to be careful with the background work. It is very important to spend time defining and understanding the problem that needs to be improved, to pause for a while in the planning phase and acquire different perspectives.” <div> </div> <div><br /></div> <div> </div> <div>“I also felt a bit old! The students were quick in both thought and language. I thought my English was decent – I don't think so anymore. They spoke English completely unhindered and seemed to use terms for quality development naturally. I was impressed by them,” says Hans Gunnarsson.<br /><br /></div> <div> </div> <h3 class="chalmersElement-H3">Complex problems require many perspectives</h3> <div> </div> <div>Student Johan Blickhammar believes that the challenges of the present and the future are often about technological development, and that Chalmers has an important role to play in contributing to the surrounding society.<br /><br /></div> <div> </div> <div>“The majority of the problems that we were presented forcould be related to digital</div> <div>transformation. For many operations, not just the Region Västra Götaland, this means a big change as people today interact with technical solutions to an increasing extent. This is a complex problem that, among other things, requires that many different perspectives are taken into account. For this, I believe that we – solution-oriented Chalmers students – are an excellent source to get help from!”</div> <div> </div> <div> </div> <div><em>Text: Daniel Karlsson</em></div> <div><em>Photo: via respective person, and Andreas Hellström</em></div> <div> </div> <div> </div> <div><strong>Collaborative project</strong></div> <div>The project is formally called SMILLA, SMall-scale live cases to Integrate Life-long Learning and Access to work-life examples. The project is a collaboration between Chalmers and Region Västra Götaland and receives funding from Vinnova. It is directed by Ida Gremyr, Professor at the Division of Service Management and Logistics, Patrik Alexandersson, Director of Centre for Healthcare Improvement (CHI) and Andreas Hellström, Senior Lecturer and Scientific Leader of CHI. <a href="/en/projects/Pages/SMILLAQ-SMall-scale-live-cases-to-Integrate-Life-long-Learning.aspx">Read more</a></div> <div> </div> <div>More about the initiative: <a href="/en/areas-of-advance/health/news/Pages/Healthcare-managers-and-engineering-students-to-tackle-healthcare-challenges.aspx">Healthcare managers and engineering students join forces</a></div> <div><a href="/en/areas-of-advance/health/news/Pages/Healthcare-managers-and-engineering-students-to-tackle-healthcare-challenges.aspx"><br /> </a></div>Thu, 27 Oct 2022 10:00:00 +0200 skier test their limits<p><b>The super skier Max Novak collaborates with Chalmers to reach new goals. He uses the physiology lab, which is located in Chalmers Makerspace Fuse.​</b></p><div><span style="background-color:initial">Novak visits Chalmers to test the limit of how fast he can ski under controlled circumstances. Dan Kuylenstierna, associate professor at Chalmers, collected measurement data that shows how each part of the body works to reach these speeds.</span><br /></div> <div><br /></div> <div>Max Novak, who is used to intensive sessions, thinks the lab is well suited for doing tests.</div> <div>&quot;It's really good with these wide, fine bands, with cameras everywhere. There is good access here in Gothenburg,&quot; says Max Novak.</div> <div><br /></div> <div>The lab consists of a large treadmill that can be tilted 25% at a speed of 50km/h. The band is suitable for skiing, running, roller skiing, inline skating, gait analysis and cycling. All around the lab are high-speed cameras and motion tracking equipment. To study cycling, in addition to the belt, there is a calibrated cycle ergometer that allows you to test workability and movement patterns. The physiology lab is used for various studies and experiments, where measurement data is collected for the analysis of human movement.</div> <div><br /></div> <div>Even robots and smaller electric vehicles can be tested on the belt.</div> <div>&quot;The measurement data can be used, for example, to train algorithms to recognize movement patterns. This will be useful in teaching but also in research,&quot; says Dan Kuylenstierna.</div> <div><br /></div> <div>During the tests with Max, a new technology with integrated sensors in the handle was used to measure force and velocity, which is required to calculate the power (in Watts). A method that has been developed by students at Chalmers.​​</div> <div>“What is happening here right now will set the standard for the future. It is the first time we have the opportunity to collaborate with such expertise as Chalmers has, at the same time as we get access to this new technology with integrated sensors in the handle, says Mattias Reck who is Max Novak's coach.<span style="background-color:initial">​</span></div> <div><br /></div> <div><strong>Photo:</strong> Hasti Razaghi</div> <div><strong>Film: </strong><span style="background-color:initial">Torgil Störner</span></div> <div><span style="background-color:initial"><strong>Text:</strong> </span><span style="background-color:initial">Hasti Razaghi​ &amp; Julia Jansson</span></div>Fri, 21 Oct 2022 14:00:00 +0200 to create healthy activity-based offices<p><b>​Activity-based offices are becoming increasingly common but also make a form of work that is more challenging for users. Research from Chalmers show that resources like noise-cancelling headphones and absorbent materials can create well-being, but above all highlights the importance of letting the concept of healthy activity-based offices develop over time, and in dialogue with users.</b></p><div>​Melina Forooraghi, Doctor at the Department of Architecture and Civil Engineering, has explored factors that make us feel well in an activity-based office environment and how design characteristics can help the user to stay healthy. Her findings highlight the importance of enabling coping with stressors in the office environment by providing a wide range of solutions – from noise-cancelling headphones to divider screens, noise absorbent materials and quiet rooms.    </div> <div> </div> <div> – A healthy activity-based office provides users with access to the resources they need to function and feel well, and is designed so that users understand how they can use and benefit from different types of workspaces, says Melina Forooraghi.    </div> <div> </div> <div>The users need resources to handle both disturbing sounds and visual impressions and means to function socially with colleagues and receive support from managers in the daily work. She emphasizes that it is of great importance to be able to see the activity-based office as moving projects that can continue to develop over time by testing different solutions and working with adaptation and remodeling.    </div> <div> </div> <div> – The management need to be in constant dialogue with the users. The fact that the construction work is finished is not synonymous with the office environment being finished to the extent that it doesn’t require more attention, says Melina.    </div> <h2 class="chalmersElement-H2">Designing for everyone is designing for no one    </h2> <div>In her research, Melina has focused on factors that can create health rather than factors that cause ill health, but she can clearly see what should be avoided: standardized design solutions. Relocations to activity-based offices are often linked to organizational mergers where people from different backgrounds, disciplines and with different tasks are brought together to work in the same space. Organizations often fail to include employee perspectives in the process, which in turn results in more generic office design that must respond to a variety of needs and differences.    </div> <div> </div> <div> – Standardized and generic design solutions are a lost opportunity because designing for everyone is the same as designing for no one. If you keep your design at a very generic level, it means it doesn't really serve anyone, says Melina.    </div> <h2 class="chalmersElement-H2">The office environment of the future    </h2> <div>The trend in office real estate is towards more activity-based offices where users share workspaces. After the pandemic, more and more organizations have adopted hybrid work, which can also lead to increased acceptance of desk sharing as many spend less time in the office. In the longer term, Melina sees further trends:    </div> <div> </div> <div> – I believe that much of the work we do today will be automated in the future, which requires us to develop our uniquely human abilities such as design, imagination, critical thinking and innovation. The office environment will be a catalyst for these skills and constitute an environment that promotes these types of activities, concludes Melina.      </div> <div> </div> <div>Melina Forooraghi recently defended her doctoral thesis: <a href="">Healthy Offices: Conceptualizing Healthy Activity-based Offices</a>   </div> <div><br />Text: Catharina Björk<br /></div>Thu, 20 Oct 2022 00:05:00 +0200​Thesis projects addressing the needs of the healthcare sector<p><b>​On 12th October, Chalmers hosted a master’s and bachelor’s thesis fair in health and technology at Johanneberg Campus. Providing the students an opportunity to pick and choose among project proposals and match themselves with supervisors from different research fields.</b></p><div><span style="background-color:initial">“It is great fun that we for the fifth time are arranging our joint thesis fair and that the interest is only increasing from both researchers and students. This year we have more than 60 project proposals presented by different researchers”, says Martin Fagerström, Co-director Health Engineering Area of Advance.</span><br /></div> <div><span style="background-color:initial"><br /></span></div> <div>The fair is a joint arrangement between Chalmers, Gothenburg University, and Sahlgrenska University Hospital. New for this year was that the fair also included proposals for bachelor's thesis.</div> <div><br /></div> <div>“It feels good that we this year have the opportunity to offer project proposals also to our Bachelor students. - It is the first class of medical engineering students who will write bachelor's theses this spring ”, says Martin Fagerström.</div> <div><br /></div> <div>The proposals presented during the day were from different subject areas and illustrated the interesting meeting between the needs of today’s healthcare and the possibilities that modern technology can offer. The proposals were both practical and dealt with advanced research questions. The subjects contained everything from Nano, VR and radar technology to infection prevention, management issues, and patients’ use of health apps.</div> <div><br /></div> <div><strong>Examples of subjects</strong></div> <div>•<span style="white-space:pre"> </span>Talk2Me – voice-based working methods </div> <div>•<span style="white-space:pre"> </span>Early stroke characterisation using video analysis</div> <div>•<span style="white-space:pre"> </span>Virtual Reality within healthcare </div> <div>•<span style="white-space:pre"> </span>Digital documentation for drop-in waiting rooms</div> <div>•<span style="white-space:pre"> </span>Patient-gathered health data to reach healthcare</div> <div>•<span style="white-space:pre"> </span>Meaningful user experience for citizens as well as healthcare professionals tracking individual health data</div> <div>•<span style="white-space:pre"> </span>Improving management of patient flows at various levels</div> <div>•<span style="white-space:pre"> </span>Management of patient groups with complex care needs: <span style="background-color:initial">Improving patient safety in real-time</span></div> <div><span style="background-color:initial"><br /></span></div> <div><strong>Increased demand for healthcare requires new working methods</strong></div> <div>Many of the project proposals regarded the needs in today’s and tomorrow’s healthcare.<br /><br /></div> <div>“We have a growing and aging population and because of advances in research and technological development, we can treat more severe diseases than before. This means that we get increased demand for healthcare, but the resources we have do not increase at the same rate. We need to manage that gap, for example by developing new working methods and tools, not at least linked to digitization, says Cecilia Hahn Berg, development strategist at Sahlgrenska University Hospital.<br /><br /></div> <div>Several of the proposals highlighted that there is a great need to transfer certain care from the hospital to the patient's home and to try to digitise and optimize time-consuming aspects of today’s healthcare, such as administration. An example of this involves voice-based working methods for ambulances. Other projects will investigate the possibility of working with fall detection, for example in the homes of elderly people. Another proposal was about developing an app to support diabetes patients in checking their own feet regularly to avoid the foot problems that are common in that patient group.<br /><br /></div> <div>Cecilia Hahn Berg is positive in regards to this year's fair also including bachelor's thesis.<br /><br /></div> <div>“It's great that the hospital, and researchers from both the University of Gothenburg and Chalmers are establishing contact between themselves and these students from start. Their skills are highly demanded, and they are our future recruitment base.<br /><br /></div> <div>The students Kajsa Homann, Elvira Carlén, and Matilda Alexandersson study the bachelor's program in medical engineering at Chalmers and are satisfied with their choice of education. Their impressions of the project presentations were positive.<br /><br /></div> <div>“It was fun to hear about the projects that dealt with major societal issues and management challenges, we haven’t had much experience with such issues yet, says Kajsa Homann.<br /><br /></div> <div>“I haven't decided yet, we won't write the master's thesis until this spring, but I became very interested in the project that was about cancer treatment, says Matilda Alexandersson.<br /><br /></div> <div><strong>Collaboration that inspires</strong></div> <div>The annual fair allows the supervisors to reach out widely with their project proposals and the students get the opportunity to ask questions directly to the supervisors. The cooperation between the universities also means that the students get the chance to work interdisciplinary with real projects, side by side with students and researchers with different competencies. In some cases, the students are supervised by researchers from both the clinical and technical side of health technology.<br /><br /></div> <div>One Chalmers professor who presented several proposals during the day was Göran Lindahl, director of the Centre for Healthcare Architecture, CVA.<br /><br /></div> <div>“The close collaboration with the healthcare sector, in this case Sahlgrenska University Hospital, gives us access to the actual operational challenges that the healthcare sector is facing, which creates relevance and provides inspiration. Having the opportunity to discuss, test, and develop ideas and knowledge together is a quality aspect of our education”.<br /><br /></div> <div>The fair not only gives the students an overall view of the current project opportunities, but it also offers an opportunity to mingle and network across programme boundaries during the mingle sessions. Several educational programmes were represented at the fair, including within Chemistry, Quality and operations management, Medical technology, Specialist nursing programme, Industrial design engineering, Engineering mathematics and computational science, Programme in Dental Hygiene, Global Health, Cognitive Science, Pharmacy, Data science and AI, Biomedical Engineering and more</div> <div><br /></div> <div>Text and photo: Julia Jansson</div> <div><br /></div>Wed, 19 Oct 2022 16:00:00 +0200 Chalmers projects receive KAW's project grants <p><b>​No less than four research projects at Chalmers are awarded SEK 109 million in project grants by the Knut and Alice Wallenberg Foundation (KAW). The projects are evaluated to be of such high quality that they can lead to future scientific breakthroughs. ​</b></p><p class="chalmersElement-P">​<span>Out of a total of 23 research projects Associate Professor Elin Esbjörner, Professor Tünde Fülöp, Professor Christian Müller and Associate Professor Witlef Wieczorek from Chalmers are awarded grants. </span></p> <div> </div> <p class="chalmersElement-P"><span style="background-color:initial">These projects are, following an international evaluation process, considered to have such high scientific potential that they could lead to future scientific breakthroughs. </span></p> <div> </div> <p class="chalmersElement-P"><span style="background-color:initial">&quot;The evaluations are based entirely on international competitiveness and are carried out by a handful of prominent researchers in each project's research area. We are delighted to see that there are so many projects in Sweden that maintain this quality and that more and more women are able to step forward as research leaders,&quot; says Siv Andersson, responsible for basic research issues at the<a href=""> Foundation​</a>. </span></p> <div> </div> <h2 class="chalmersElement-H2"><span>Project: Nanochannel Microscopy for Single Exosome Analysis </span></h2> <div> </div> <p class="chalmersElement-P"> </p> <div> </div> <p class="chalmersElement-P">Exosomes are ultrasmall biological packages that cells use to communicate. Exosomes are important for our bodies’ normal functions, but can also confer disease. This project aims to further our fundamental understanding of how exosomes mediate cell-cell communication. To accomplish this goal, new methodology is needed. </p> <div> </div> <p class="chalmersElement-P">In this project, we will therefore develop new microscopy methods and chip-based technologies, using tiny channels and traps to capture and analyse individual exosomes from biological specimen or cell models. This will provide new possibilities to obtain detailed information about the composition and content of different exosome types, which, if tied to their discrete function may open entirely new possibilities for how to use exosomes as diagnostic tools and future therapeutics, especially in the area of targeted delivery of protein- and RNA-based drugs. </p> <div> </div> <p class="chalmersElement-P"> </p> <div> </div> <p class="chalmersElement-P"><strong>Grant: </strong>SEK 29,100,000 over five years </p> <div> </div> <p class="chalmersElement-P"> </p> <div> </div> <p class="chalmersElement-P"><strong>Principal investigator:</strong> Associate Professor <a href="/en/staff/Pages/Elin-Esbjörner-Winters.aspx">Elin Esbjörner</a>, Department of Biology and Biological Engineering </p> <div> </div> <p class="chalmersElement-P"> </p> <div> </div> <p class="chalmersElement-P"><strong>Co-applicants in the project: </strong>Fredrik Westerlund and Christoph Langhammer (Chalmers), Samir EL Anadloussi (Karolinska Institutet) and Giovanni Volpe (Göteborgs universitet)</p> <div> </div> <p class="chalmersElement-P"> </p> <div> </div> <h2 class="chalmersElement-H2">Project: Extreme Plasma Flares  </h2> <div> </div> <p class="chalmersElement-P"> </p> <div> </div> <p class="chalmersElement-P">Plasma flares give rise to some of the most beautiful phenomena in the universe, such as the aurora borealis, but they can also cause damage to important technological infrastructure on ground or in space. However, it is still unknown what conditions are required to create eruptions with extremely strong energy flows. The project combines theoretical and experimental competences from both space and laboratory plasma physics to understand which combination of effects creates extreme flares. </p> <div> </div> <p class="chalmersElement-P"> </p> <div> </div> <p class="chalmersElement-P">A better understanding will lead to tools that can warn of such flares, so that sensitive equipment can be protected. But above all, the project will contribute to a basic understanding of some of the most fascinating phenomena in physics. </p> <div> </div> <p class="chalmersElement-P"> </p> <div> </div> <p class="chalmersElement-P"><strong>Grant:</strong> SEK 26,200,000 over five years  </p> <div> </div> <p class="chalmersElement-P"> </p> <div> </div> <p class="chalmersElement-P"><strong>Principal investigator: </strong>Professor <a href="/en/Staff/Pages/Tünde-Fülöp.aspx">Tünde Fülöp</a>, Department of Physics </p> <div> </div> <p class="chalmersElement-P"> </p> <div> </div> <p class="chalmersElement-P"><strong>Co-applicants in the project:</strong> István Pusztai from the same department, Andris Vaivads from KTH Royal Institute of Technology, and Yuri Khotyaintsev from the Swedish Institute of Space Physics. </p> <div> </div> <p class="chalmersElement-P"> </p> <div> </div> <h2 class="chalmersElement-H2">Project: Developing stable and sustainable organic semiconductors  </h2> <p class="chalmersElement-P"><span style="background-color:initial">Orga</span><span style="background-color:initial">nic semiconductors can make the electronics we use more sustainable and provide us with new alternatives to silicon-based technology. This technology could be used in a lot of different areas and greatly improve our lives. For example, organic semiconductors can be used in bioelectronic sensors that can help us monitor our health and wellbeing. Other examples of urgent applications are technologies to capture energy such as organic solar cells. Both research and industry see great needs and opportunities in this area, provided that organic electronics can become more stable. </span></p> <p class="chalmersElement-P"><span style="background-color:initial">Within this project, the researchers will study doping of organic semiconductors. In particular, new insights related to glass-forming materials will be used to develop more stable organic electronics. </span></p> <p class="chalmersElement-P"><strong>Grant</strong>: SEK 27,000,000 over five years  </p> <p class="chalmersElement-P"><strong>Principal investigator:</strong> Professor <a href="/en/staff/Pages/Christian-Müller.aspx">Christian Müller</a>,  Department of Chemistry and Chemical Engineering, Chalmers   </p> <p class="chalmersElement-P"><span style="background-color:initial"><strong>Co-applicants in the project: </strong>Anna Martinelli and Eva Olsson from Chalmers, Simone Fabiano and Mats Fahlman from Linköping University  </span></p> <h2 class="chalmersElement-H2"><span>Project: Light strongly interacting with mechanical motion </span></h2> <h2 class="chalmersElement-H2"> </h2> <h2 class="chalmersElement-H2"> </h2> <h2 class="chalmersElement-H2"> </h2> <p class="chalmersElement-P">Scientists use light as a tool to acquire information about objects. This is also the case when laser light is shined onto a mirror. The reflected light field contains information about the mirror’s position. This measurement scheme is for example used in gravitational wave detectors. The information about the mirror’s position can be vastly increased by capturing the light between two mirrors, in so-called cavity optomechanical systems. These systems not only enable measuring the position of the mirror very precisely, but also controlling its motion, even to its quantum mechanical ground state. This has fascinated scientists as it allows exploring the validity of quantum physical laws for larger objects. The next major challenge in this research field is to increase the interaction between light and the motion of the mirror until it is possible to create quantum mechanical states of the mirror directly. </p> <div> </div> <p class="chalmersElement-P"> </p> <div> </div> <p class="chalmersElement-P">The aim of this project is to reach the so-called nonlinear regime of quantum optomechanics in chip-based devices. Then, single light particles (photons) and the quantized motion of the mirror (phonons) are linked to each other in a controlled way. If one succeeds with this ambitious goal, one can, for instance, detect individual photons without destroying them and the quantum information that they carry. An important area of application of this ability lies in the field of quantum technology. For example, having access to the nonlinear regime could lead to the development of novel chip-based devices that can detect significantly smaller forces and displacements than what the most advanced technologies allow us to do today.<span> </span> </p> <div> </div> <p class="chalmersElement-P"> </p> <div> </div> <p class="chalmersElement-P"><strong>Grant: </strong>SEK 27,000,000 over five years </p> <div> </div> <p class="chalmersElement-P"> </p> <div> </div> <p class="chalmersElement-P"><strong>Principal investigator:</strong> Associate Professor <a href="/en/staff/Pages/witlef-wieczorek.aspx">Witlef Wieczorek​</a>, Department of Microtechnology and Nanoscience (MC2)</p> <div> </div> <p class="chalmersElement-P"> </p> <div> </div> <p class="chalmersElement-P"><strong>Co-applicants in the project:</strong> Andreas Isacsson and Philippe Tassin (Physics) and Janine Splettstoesser (MC2), and encompasses Chalmers' expertise in experiment, theory, and artificial intelligence. </p> <p class="chalmersElement-P"><br /></p> <p class="chalmersElement-P"><strong>Read more: </strong><a href="">KAW Research Projects 2022</a></p> <div> </div> <p class="chalmersElement-P"> ​</p>Fri, 14 Oct 2022 09:00:00 +0200 3D printed food alleviate age-related malnutrition?<p><b>​Age-related malnutrition is a serious problem that is primarily caused by insufficient food intake. Over the age of 70, more than 40 percent of the population will suffer from swallowing problem. Research shows that a diet with customized texture and taste makes swallowing easier for those, and that 3D printed food can make meals more appetizing, all with the help of materials science.</b></p><div>Insufficient food intake can have more causes than dysphagia, the medical term for swallowing disorders, but it is a very common problem for the elderly. It risks leading to age-related malnutrition that makes us more frail, which often leads to lack of independence, fall accidents and hospitalization. It not only causes suffering for the individual, but also entails great costs for society. In Sweden alone, the cost of age-related malnutrition is estimated to SEK 9 billion annually.</div> <div> </div> <div><img src="/SiteCollectionImages/Institutioner/IMS/Konstruktionsmaterial/3D-printadmat_MatsStading_02.jpg" alt="Mats Stading" class="chalmersPosition-FloatRight" style="margin:5px 15px;width:367px;height:260px" />Mats Stading studies how materials science can be used to produce food that is easy to chew and swallow, but still resembles ordinary food as much as possible. It starts with producing a slow-flowing, so-called viscoelastic paste with different textures and flavors adapted to personal needs. 3D-printed food is produced by &quot;printing&quot; the paste into shapes similar to regular food, and then baking it to a firm, but easily chewable and swallowable consistency.</div> <div><br /></div> <div> </div> <div><br /></div> <div> </div> <div>“The research results clearly show that food consistency can be modified making it easier to both chew and swallow safely, and still remaining tasty. When combining this with 3D printing, we can produce exciting meals that look a lot like regular food”, says Mats Stading, adjunct professor at Chalmers.</div> <div> </div> <div><br /></div> <div><h2 class="chalmersElement-H2">The 3D-printer could be seen as any other kitchen appliance<br /></h2></div> <div> </div> <div><img src="/SiteCollectionImages/Institutioner/IMS/Konstruktionsmaterial/3-printad%20broccoli.jpg" alt="broccoli" class="chalmersPosition-FloatRight" style="margin:5px 35px;width:244px;height:149px" />The idea is to be able to serve 3D printed food both in nursing homes and in a home environment. The technology exists and as has been proven to work, but there are a number of measures required for it to work in clinical or home setting. An important part is that food producers are involved and develop products that can be used on a larger scale.</div> <div><br /></div> <br /><div> “In the future, 3D printed food will probably be a regular feature, but initially extra support may be required if something goes wrong. The 3D printer's speed and specifications are still somewhat limited, but technology development is progressing quickly in this area”, says Astrid Ahlinder, researcher at RISE.</div> <div><br /></div> <div><br /></div> <div><img src="/SiteCollectionImages/Institutioner/IMS/Konstruktionsmaterial/3D-printadmat_japambassador.jpg" alt="3d-printad mat visas" class="chalmersPosition-FloatLeft" style="margin:5px" /><br /><br /><em>The research is drawing great interest in Japan, which has the oldest population in the world. Here, Japan's ambassador gets a demonstration on how to 3D-print food.</em> </div> <div><br /></div> <div>The research is important because many countries have an increasingly high proportion of elderly, in Sweden 20 percent are over 65 and in Japan the corresponding figure is as high as 30 percent. Mats Stading has also collaborated with, among others, Japanese researchers regarding 3D printed food.</div> <div> </div> <div><br /></div> <div> “There is great interest in both countries, so it has been a natural collaboration. We also had the opportunity to combine the research on 3D-printed food with other studies that examine exercise and social interaction. It is important to look at a whole picture to prevent frailty and not just individual parts”, Mats states.</div> <div><br /></div> <h2 class="chalmersElement-H2">Do you want to know more about 3D-printed food? </h2> <div>Contact <a href="/sv/Personal/Sidor/mstading.aspx">Mats Stading</a> if you want to know more about the research on 3D-printed food.<br /></div> <div><br /></div> <div><em>Text &amp; photo: Marcus Folino</em><br /></div>Thu, 13 Oct 2022 10:00:00 +0200 care through understanding of new concepts<p><b>​Fashionable ideas like 'Lean', 'Value-based healthcare' and 'Learning health systems' tend to succeed each other as contemporary ideas on how to improve healthcare. But how can healthcare managers handle these management innovations in a way that results not only in pretty words but in actual improvements? Christian Colldén is a physician and healthcare manager who in his doctoral thesis at Chalmers has studied how management innovations can be understood and translated into a local context to improve the quality and efficiency of care.</b></p><h3 class="chalmersElement-H3">​What challenges do you focus on in your research?</h3> <div>&quot;All those who have tried to improve healthcare systems have probably realised that it is a very challenging undertaking. Demands often come from many directions, strong professions with diverse opinions and views are to be brought on the same track, and processes are seldom straight and separate. Management innovations are often presented as comprehensive and consummate concepts, which will solve the problems of healthcare, but earlier research have shown that they often do not deliver the promised improvements. Healthcare professionals also often meet management innovations with skepsis. On the other hand, there are examples of management innovations being positively received and resulting in improved quality and efficiency. The challenge that I focus on is how managers can improve the complex healthcare systems that they act in, and how management innovations can become useful tools in that work.&quot;</div> <h3 class="chalmersElement-H3">How do you address the problem with your research?</h3> <div>&quot;I have been inspired by action research, which implies that I have tried to achieve improvements in my own context at the same time as I have collected data to analyse what me and my colleagues have done in practice. I have worked in psychiatry within the Sahlgrenska University Hospital and, hopefully, the projects have created better conditions for innovativeness quality improvements. At the general level I try to contribute to a better understanding of how to use management innovations so that they are positively received by different actors in healthcare and create improvements. That general knowledge can be used in education for managers and staff who support managers in development and improvement work.&quot;</div> <h3 class="chalmersElement-H3">What are the main findings?</h3> <div>&quot;Different actors in healthcare, like nurses, physicians, politicians, and care developers, have different views on what quality in care means, how care should be provided in a high-quality fashion, and how improvements can be achieved. Thus, they can be seen to rely on different logics. In the same way, different management innovations rely on one or several logics. By mapping underlying logics, healthcare managers can create an appreciation for the complex system and match concepts with the context.&quot;</div> <div> </div> <div>&quot;Next, managers should translate rather than implement management innovations, which implies that one should view them not as fixed concepts but as mouldable ideas. A concrete example is Value-based Healthcare, which can be seen as relying on both a logic of standardisation (of care processes for defined patient groups) and a logic of goal orientation (that if we measure outcomes and costs, the manager need not decide how the result is to be achieved). Based on the understanding of what is needed and/or will be best received in the specific organisation, different aspects of management innovations can be emphasized to make a positive impact and drive change. Management innovations in themselves seldom solve the problems but they can be used as strategic tools and sources of inspiration.&quot;</div> <h3 class="chalmersElement-H3">What do you hope your research will lead to? </h3> <div>&quot;Unfortunately, there are no shortcuts to improvements in healthcare, but research can provide some advise on how to take on the task. For example, appreciation of the surrounding system and its components – especially what drives the individuals that you want to involve in new ways of working. I hope that managers and others who drive development in healthcare can adopt that approach and that it is also highlighted in management training programmes, by internal support functions for care development, and by external consultants. If this view gains impact, I believe that frustration can be turned into constructiveness and real improvements.&quot;</div> <div> </div> <div><br /><br /></div> <div> </div> <div><em>Text compilation: Daniel Karlsson</em><br /></div> <div> </div> <div><br /></div> <div>Read the thesis <a href="" target="_blank">&quot;Managing management innovations: Contextual complexity and the pursuit of improvements in healthcare&quot;</a></div> <div> </div> <div>The author will defend the thesis on 7 October 2022 at 13.15, see link on the <a href="" target="_blank">thesis’ page</a><br /></div> <div> </div> <div><br /></div> <div> More about <a href="/en/Staff/Pages/christian-ohrn.aspx">Christian Colldén</a></div> <div> </div>Thu, 29 Sep 2022 09:00:00 +0200 from Chalmers heading for Silicon Valley<p><b>​Every year the Swedish innovation agency Vinnova selects research projects for the exclusive incubator program Reach with focus on technology relevant for the ecosystem in Silicon Valley and with the potential to be commercialised. This year, two of the ten selected projects are based on research at Chalmers.   </b></p>​<span style="background-color:initial">The research projects from Chalmers are both about innovations that can contribute in developing new medicines and vaccines. In order for the discoveries to be utilised and commercialised, they are further developed by the startup companies LanteRNA and Envue Technologies. The Swedish projects chosen for Reach are selected from the Royal Swedish Academy of Engineering Sciences &quot;IVA 100 list&quot; and have already been carefully reviewed.  </span><div><br /></div> <div>Below, the researchers comment on how being selected to Reach will affect their projects.   </div> <div><br /></div> <div><strong>Marcus Wilhelmsson</strong>, Professor at the Department of Chemistry and Chemical Engineering and <strong>Elin Esbjörner</strong>, Associate Professor at the Department of Biology and Biological Engineering, about the research project and startup LanteRNA:   </div> <div><br /></div> <div>&quot;We are excited that our academic research from which these ideas originate is now receiving an additional push forward and coaching to become an important tool for drug developers worldwide by shortening lead times for new RNA-based medicines. It shows how important it is for academic research to be ready for new societal challenges, such as a pandemic. The program will help us understand the demands today and in the future from stakeholders where our technologies can be used and thus lead to new academic research projects that can hopefully help solve the next issue in industry and society.&quot; </div> <div><br /></div> <div>Read more about the research: <span style="background-color:initial"><a href="/en/departments/chem/news/Pages/Breakthrough-fortracking-RNA-with-fluorescence-.aspx">Breakthrough for tracking RNA with fluorescence</a></span></div> <div> </div> <div><br /></div> <div><strong>Christoph Langhammer</strong>, Full Professor at the Department of Physics, about the research project and startup Envue Technologies: </div> <div><br /></div> <div>“First of all, this means that we’ve got a good receipt on the relevance of our research and its utilisation potential, which we are of course very happy about. Not the least since the results originate from a project that has had a rather large extent of focus on fundamental research. That tells us once again how import fundamental research is if you want to make new discoveries. Another aspect of what the utilisation in general and the Reach program in particular means for our research is that we can build networks of stakeholders for our technique beyond the purely academic world, which will lead me to new research ideas that I wouldn’t have thought of otherwise.” </div> <div><br /></div> <div><span style="background-color:initial">Read more about the research:​ </span><a href="/en/departments/physics/news/Pages/Nanochannels-light-the-way-towards-new-medicine.aspx">Nanochannels light the way towards new medicine</a></div> <div><br /></div> <div><a href="">Read the press release from the Royal Swedish Academy of Engineering Sciences (in Swedish</a>)  </div> <div> </div>Wed, 28 Sep 2022 15:00:00 +0200 year's Tandem Webinars<p><b>​Here you will find 2022 all Tandem Webinars. All the webinars can be watched afterwards via Chalmers Play. ​</b></p><div></div> <div><span style="background-color:initial"><b>Upcoming webinars:</b></span></div> <div><b><br /></b><span style="background-color:initial"><b></b><div><span style="background-color:initial;font-weight:700">2 February, 2023. TANDEM SEMINAR</span><span style="background-color:initial">:</span><span style="background-color:initial;font-weight:700"> </span><b>Material recycling –  possibilities, shortcomings and policy instruments<br /></b><strong>Focus: </strong><span style="background-color:initial"><strong>Metal recycling.</strong></span></div> <span></span><div>Welcome to a webinar with Christer Forsgren, Consultant in Industrial Recycling and Christian Ekberg, Prof. Energy and Material, Industrial Materials Recycling and Nuclear Chemistry. <br /><strong>Moderator:</strong> Leif Asp.<br /><strong>Time:</strong> 12:00-13:00<br /><strong>Place:</strong> Online, platform Zoom.<br /><br /><a href="" style="outline:0px;font-size:16px"><img class="ms-asset-icon ms-rtePosition-4" src="/_layouts/images/icgen.gif" alt="" /></a><a href="" style="font-size:16px"><div style="display:inline !important">Register to the webinar</div></a><br /><br />December, 2022 TBA</div> <br /><b>Wat</b></span><span style="background-color:initial;font-weight:700">ch 2022 year´s seminars on Chalmers Play</span><span style="background-color:initial;font-weight:700">:<br /></span>5 October: <span style="background-color:initial;font-weight:700">TANDEM SEMINAR</span><span style="background-color:initial"> </span><span style="background-color:initial;font-weight:700">– </span><a href=""><span style="background-color:initial">M</span><span style="background-color:initial">etallic nanoalloys for next generation optical hydrogen sensors</span></a></div> <div><span style="background-color:initial">Welcome to Professor Christoph Langhammer and Lars Bannenberg´s Tandem webinar. Hydrogen: clean &amp; renewable energy carrier, with water as the only emission. But it is highly flammable when mixed with air. Very efficient and effective sensors are needed.​ <br /><a href=""><img class="ms-asset-icon ms-rtePosition-4" src="/_layouts/images/icgen.gif" alt="" />Watch the webinar on Chalmers Play</a></span></div> <div><span style="background-color:initial;font-weight:700"><br /></span></div> <div><span style="background-color:initial;font-weight:700">8 September: </span><span style="background-color:initial;font-weight:700">TANDEM SEMINAR</span><span style="background-color:initial"> </span><span style="background-color:initial;font-weight:700">– </span><span style="background-color:initial"><b>New Insulation Materials for High Voltage Power Cables<br /></b>In this webinar two hot topics are covered by Christian Müller, Professor at the Department of Chemistry and Chemical Engineering, Chalmers University of Technology, and Per-Ola Hagstrand,  Expert at Borealis Innovation Centre. Adjunct Professor at Applied Chemistry, Chalmers University of Technology.<br /><span></span><a href=""><img class="ms-asset-icon ms-rtePosition-4" src="/_layouts/images/icgen.gif" alt="" />Watch the webinar on Chalmers Play​</a>​<br /><br /><br /></span><div><span style="background-color:initial;font-weight:700">11 April</span><span style="background-color:initial;font-weight:700">: </span><span style="background-color:initial;font-weight:700">TANDEM SEMINAR</span><span style="background-color:initial"> </span><span style="font-weight:700;background-color:initial">– </span><span style="background-color:initial"><b>Perspectives on cellulose nanocrystals<br /></b></span><span style="font-size:16px">In this tandem webinar</span><span style="font-size:16px;background-color:initial"> </span><span style="font-size:16px">we have two hot topics dedicated to Cellulose nanocrystals: Cellulose nanocrystals in simple and not so simple flows &amp; Using liquid crystal phase separation to fractionate cellulose nanocrystals.</span><br /></div> <div><a href="" style="outline:0px"><img class="ms-asset-icon ms-rtePosition-4" src="/_layouts/images/icgen.gif" alt="" />Watch the webinar on Chalmers Play</a><div><br /></div> <div><div><span style="font-weight:700">Program:</span></div> <div><ul><li>Moderator: Leif Asp, Co-Director Chalmers Area of Advance Materials Science</li> <li>C<span style="background-color:initial">ellulose nanocrystals in simple and not so simple flows, <a href="/en/staff/Pages/roland-kadar.aspx">Roland Kádár</a>, Associate Professor, Chalmers University of Technology.</span></li> <li>U<span style="background-color:initial">sing liquid crystal phase separation to fractionate cellulose nanocrystals.<a href=""> Jan Lagerwall</a>, Professor at the Physics &amp; Materials Science Research Unit in the University of Luxembourg.</span> </li></ul></div></div></div> <div><br /></div> <div><span style="font-weight:700;background-color:initial">30 May: </span><span style="background-color:initial;font-weight:700">TANDEM SEMINAR</span><span style="background-color:initial"> </span><span style="background-color:initial;font-weight:700">– </span><b><span></span>Lipid nanoparticles for mRNA delivery</b><br /><span style="background-color:initial"><a href=""><img class="ms-asset-icon ms-rtePosition-4" src="/_layouts/images/icgen.gif" alt="" />Watch the webinar on Chalmers Play</a><br />Organizer: Chalmers Area of Advance Mater</span><span style="background-color:initial">ials Science.<br /></span>The role of supramolecular lipid self assembly and protein corona formation for functional mRNA delivery to cells. Two hot topics will be covered by Elin Esbjörner and Fredrik Höök​.<br /><div><br /></div> <div><ul><li>Moderator: Maria Abrahamsson, Director of Materials Science Area of Advance </li> <li><a href="/en/staff/Pages/Fredrik-Höök.aspx">Fredrik Höök</a>, <em>Professor, Nano and Biophysics, Department of Physics, Chalmers University of Technology</em>.</li> <li><span style="background-color:initial"><a href="/en/staff/Pages/Elin-Esbjörner-Winters.aspx">Elin Esbjörner</a>, </span><i>Associate Professor, Biology and Biological Engineering, Chemical Biology, Chalmers University of Technology.</i></li></ul></div></div> <div> <div><strong>Read more:</strong></div></div></div> <a href="/en/areas-of-advance/materials/news/Pages/2021-tandem-seminars.aspx"><img class="ms-asset-icon ms-rtePosition-4" src="/_layouts/images/ichtm.gif" alt="" />2021 year's Tandem Webinars</a>​.​Tue, 27 Sep 2022 00:00:00 +0200’s-stomachs-.aspx research calms elite athlete’s stomachs<p><b>​When professional athletes shall perform under high physical pressure, they need to consume a lot of sugar. That can lead to difficult problems with their stomachs and intestines. A sport beverage, based on research by Anna Ström at Chalmers University of Technology has been shown to be able to reduce the problems and help to increase the athlete's performance.</b></p>​<span style="background-color:initial">“We won” the phone was filled with enthusiasm when the entrepreneur Olof Sköld phoned the researcher Anna Ström to tell her that their joint work literally had contributed to cross a goal line in the sports world. It was of course a somewhat peaked description but the runner who had won the Marthon in question and had managed to do it very fast, had used the sports beverage that was based on their cooperation.</span><div><span style="background-color:initial"><br /></span></div> <div>The story behind that phone call starts in 2015. Together with the triathlete Mårten Fryknäs, Olof Sköld had identified that many athletes suffered from difficult digestion problems, because they have to consume large amounts of sugar to be able to perform on a high level. Olof Sköld had heard about Anna Ström´s expertise and contacted her. They started to discuss how this problem could be solved, based on Anna Ströms long research on polysaccharides. P<span style="background-color:initial">olysaccharides is different</span><span style="background-color:initial"> sorts of sugar that are stuck together. </span></div> <span></span><div><br /></div> <div>“Our discussions and the collaboration became very interesting. I contributed with knowledge and a realistic view on what we could do. Olof Sköld is a super-visionary person. He used his large network to reach out to athletes who could be intrested in trying our idea”, says Anna Ström, Professor at the Department for Chemistry and Chemical Engineering. </div> <div><h2 class="chalmersElement-H2" style="font-family:&quot;open sans&quot;, sans-serif">Users own experience and new research confirms the effect ​</h2></div> <div>After testing different configurations of the polysaccharides in her research, Anna Ström concluded that the polysaccharides should be formed as a hydrogel directly in the stomach. In that way the sugar was picked up by the body when it reached the intestinal which made it possible for the athletes to consume a lot of sugar in a short time, without feeling sick. In collaboration with her colleague Luca Marciani in the UK and thanks to a grant from Chalmers Innovation Office, Anna Ström could do a study to verify the research with humans. <a href="" title="Link to the scientific article Alginate and HM-pectin in sports-drink give rise to intra-gastric gelation in vivo">The study was published in the scientific journal Food and Function</a>.</div> <div><br /></div> <div>“By using MRI (Magnetic resonance imaging), we could see that we got a gel in the stomach that was dissolved in the intestine. We also saw that the gel itself prevented the absorption of sugar, by measuring the participants the blood sugar. They were not professional athletes, but the study showed that the concept worked, explains Anna Ström <br /><span style="color:rgb(33, 33, 33);font-family:&quot;open sans&quot;, sans-serif;font-size:20px;background-color:initial">​</span></div> <div>They had a recipe for the beverage which made it possible to apply for a patent. Olof Sköld founded the company Maurten that owns the patent. After this stage Anna Ström has not been personally involved more in the beverage, but other researchers have done more studies which have provided various answers on the hydrogels effect. This hasn’t stopped the beverage from becoming popular in the sports world. <br /><br /></div> <div>“Many athletes have tried the beverage and continued to use it because they think it works. But now there is also a scientific article that more clearly confirms the hydrogels positive effects on the stomach problems and the performance.<a href="" title="Read the article Glucose and Fructose Hydrogel Enhances Running Performance, Exogenous Carbohydrate Oxidation, a"> The study was done by independent researchers in England, Australia and Scotland and was published in January this year</a>&quot;, says Anna Ström. </div> <h2 class="chalmersElement-H2">Price for impact in society puts the research in the spotlight </h2> <div>As researcher Anna Ström has chosen the approach &quot;act but not to be seen&quot;. She is more comfortable with that role, but she is confident that she would have got more attention if she had whished for it. When she now gets Chalmers Impact Award the withdrawn approach will be changed a bit. <br /><br /></div> <div>&quot;Of course, it is very nice and an honor to get this award. I share it with Olof Sköld and a lot of other people, but it feels good to be fronting our work in this context&quot;, says Anna Ström</div> <div><br /></div> <div>More information, contact </div> <div><a href="/en/Staff/Pages/anna-strom.aspx" title="Link to Anna Ström personal profile page ">Anna Ström</a>, Professor at the Department for Chemistry and Chemical Engineering</div> <div><br /></div> <div>​​​​Text: Jenny Holmstrand <br />Photo: Chalmers/Sara Salehi</div> ​​​Thu, 15 Sep 2022 11:00:00 +0200