Mass spectrometry imaging using MALDI and ToF-SIMS.
ToF-SIMS IONTOF V
SIMS is suitable for a wide variety of applications, for example, grain boundary analysis, characterization of stress corrosion cracking, sub-cellular drug/peptide imaging and nitrogen fixation studies in bacteria.
The industry standard ToFSIMS 5 imaging instrument from IONTOF is equipped with a bismuth cluster ion gun for nanometer scale imaging along with a Cs/Argon GCIB/O2 sputter guns for depth profiling of organic and inorganic materials.
The instrument is equipped with a reflectron TOF analyser giving high secondary ion transmission with high mass resolution, a sample chamber with a 5-axis manipulator (x, y, z, rotation and tilt) for flexible navigation, a fast entry load-lock, charge compensation for the analysis of insulators, a secondary electron detector for SEM imaging, a state-of-the-art vacuum system, and an extensive computer package for automation and data handling.
- High imaging resolution with Bi cluster ion source (<75 nm)
- Outstanding performance for low energy depth profiling (Cs, O2)
- Argon Gas cluster ion source sputtering (GCIB)
- Small area depth profiling capabilities
- FIB-SIMS capabilities
- Unmatched dynamic range and detection limit
- Sophisticated software for ease of operation and data handling
- mass resolution > 10 000
- mass range 0 – 2000 m/z,
- accuracy 5-10 ppm
FT-ICR ESI/MALDI
Thanks to a recent grant from WISE, the Wallenberg Initiative Materials Science for Sustainability, financed by the Knut and Alice Wallenberg foundation, we can now offer access to the Bruker scimaX MRMS.
The scimaX MRMS instrument includes a ParaCell 2xR MRMS detector, electronics for data acquisition and instrument control, and a 7T superconducting conduction-cooled magnet, without the need for cryogen fill or a quench line. The scimaX MRMS system provides extreme mass resolution (>20 000 000 MRP) also in highly complex samples, suited for various applications like MALDI Imaging, Metabolomics, Petroleomics, and complex polymer analysis. It includes Bruker’s dual ESI/MALDI dual source with a standard electrospray ionization (ESI) interface, quickly interchangeable with optional APPI, APCI, GC-APCI sources. The scimaX is equipped with a matrix assisted laser desorption ionization (MALDI) setup including SmartBeam II™ laser enabling e.g. MALDI imaging workflows.
- mass resolution > 20,000,000,
- mass range 50 – 10,000 m/z,
- imaging <10 um,
- MS/MS with CID, ETD, EID fragmentation
- ESI, DART and MALDI ion sources
- accuracy 600 ppb