Nima Aliakbarinodehi

Researcher, Nano and Biophysics, Department of Physics

I joined Biological Physics in May 2018 as a postdoctoral researcher through FoRmulaEx program. With a background in microsystems, my research during my PhD period at École Polytechnique Fédérale de Lausanne, Switzerland, focused on the design, fabrication and characterization of biosensors for biochemical/electrical detection of cancer-related metabolites and biomarkers.
My project is part of the FoRmulaEx, an industrial research centre for functional RNA delivery, constituting Chalmers University of Technology, University of Gothenburg, Karolinska Institutet, the Swedish Foundation for Strategic Research (SSF), AstraZeneca, and other company partner. The final aim of the program is to contribute fundamentally in understanding the mechanism of cytosolic delivery of molecules, and paving the way toward more efficient drug-delivery systems for the next generation of nucleotide-based drugs.
Currently, I am studying the interaction of RNA-loaded lipid nanoparticles (LNPs) with model lipid membranes to mimic their interaction with endosomal membranes. Such studies would provide deeper insight in the endosomal escape process with the aim of improving the cytosolic delivery of RNA following endocytosis.

Published: Mon 19 Oct 2020.