Advanced molecular and synthetic biology

Course overview

  • Course codeFBBT002
  • ECTS credits7.5
  • DepartmentLIFE SCIENCES
  • Graduate schoolBioscience
  • LanguageEnglish
  • Nordic Five Tech (N5T)The course is free of charge for PhD students from N5T Universities.
  • ApplicationContact the course coordinator

Course coordinator

About the course

  • Analysis and interpretation of scientific articles
  • In silico synthetic or molecular biology project as a group assignment
  • Structure and function of nucleic acids in vitro and in biological systems
    • Gene replication and regulation at the transcriptional and post-transcriptional level
    • RNA-protein interactions and RNA-protein inclusions (mRNPs) in post-transcriptional gene regulation
    • Methods used to study and measure post-transcriptional mRNA translation, stability and localization
    • Methods to investigate structure and dynamics of nucleic acids and processes involving these
  • Technologies and applications for synthetic biology in vivo
    • Genetic parts, devices, synthetic circuits
    • DNA assembly methods
    • Synthetic genomes
    • Advanced CRISPR/Cas9 based technologies including CRISPRa/i and CRISPR-based high throughput screening
    • Genetic biosensors, in vivo evolution and biosensor-based high throughput screening
  • RNA as a therapeutic and research tool
    • Design and function of RNA-based therapeutic modalities and their clinical potential
    • Use of RNA to regulate cell function in molecular biology research, at cellular, tissue and organism level
    • Synthesis, modification and formulation of RNA for delivery
    • Methods, mechanisms and measurements for RNA delivery

More information

Yvonne Nygård

Literature

Scientific articles, review articles.

Lecturer

Yvonne Nygård