Scale up of organic chemical reactions

The Course gives an overview of the multi-disciplinary nature and of important elements of scale up of chemical reactions, from the initial findings in laboratory synthetic route for making milligram or gram quantities of a chemical into a process for manufacturing multi-kilogram research scientists. Theoretical aspects from books and case studies from literatures will be covered and discussed. The course will have a focus on pharmaceutical and fine chemicals but will also cover the new feedstock routes that most probably will be developed from bioresources.
The course will start from a few literature examples on the scale up of multi-step reactions to give the students a general view on scale up processes in organic chemistry.
Continue with a desk-analysis/screening of the thermokinetics, solvent selection and unstable group identification to continue to scale up design, including choice of raw materials, reagents, optimizing chemical reactions and make them robust.

Gunnar Westman, westman@chalmers.se

Chapters from books and research articles
Books:

• Chemical Engineering in the Pharmaceutical Industry - R&D to Manufacturing
• Industrial organic chemistry
• Pharmaceutical Process Development: Current Chemical and Engineering Challenges
• Biorefinery: From Biomass to Chemicals and Fuels

Gunnar Westman + invited