Advanced biological nanoparticle analytics for medical and pharmaceutical applications

Agenda

13.15-14.00

Prof. Philipp Kukura, University of Oxford

Title: Unravelling biomolecular structure, interactions and dynamics with mass photometry

Abstract: Interactions between biomolecules control the processes of life, and their malfunction in disease, making their characterization and quantification essential to our understanding of the underlying molecular mechanisms. A major challenge stems from the intrinsic heterogeneity and dynamics of molecular machines and its correlation with function and regulation. I will introduce mass photometry (MP), the accurate and precise mass measurement by light scattering, which enables the study of stoichiometries, structure, energetics and kinetics of individual biomolecules in solution. These capabilities provide a dynamic view of complex processes at the macromolecular level, which I will illustrate with recent results revealing the molecular dynamics driving protein polymerization, and the importance of intermolecular interactions for viral infection and therapeutic intervention. 

14.15-14.45

Assoc. Prof Per Augustsson, Lund University

Title: Sorting particles by sound

15.00-15.30

Assist. Prof. Erdinc Sezgin, SciLifeLab/Karolinska Institute

Titel: Measuring biophysical properties of cells and nanoscale bioparticles in health and disease