Verena Siewers

Research Professor, Molecular Biology;
Biology and Biological Engineering, Systems and Synthetic Biology

siewers@chalmers.se +46317723853 Find me http://orcid.org/0000-0002-9502-9804

Verena Siewers is a Research Professor at the Department of Biology and Biological Engineering in the Systems and Synthetic Biology Group. Her main research interest is the application of yeast as a cell factory for sustainable production of a variety of chemicals as well as advanced biofuels. This also includes the development of synthetic biology tools to improve the construction of efficient yeast strains. Verena Siewers is furthermore involved in the Novo Nordisk Foundation Center for Biosustainability and the FORMAS Center for Metabolic Engineering.

Publications
Collaboration and projects

Major publications
Functional expression and characterization of five wax ester synthases in Saccharomyces cerevisiae and their utility for biodiesel production

Author: Shuobo Shi; Juan Octavio Valle Rodriguez; Sakda Khoomrung; Verena Siewers; Jens B Nielsen

Published: 2012

Published in: Biotechnology for Biofuels

Publication type: Journal article
dynamic control of gene expression in saccharomyces cerevisiae engineered for the production of plant sesquiterpene alpha-santalene in a fed-batch mode

Author: Gionata Scalcinati; Christoph Knuf; Siavash Partow; Yun Chen; Maury Jerome; Schalk Michel; Daviet Laurent; Jens B Nielsen; Verena Siewers

Published: 2012

Published in: Metabolic Engineering

Publication type: Journal article
Latest publications

2022
Dataset for suppressors of amyloid-beta toxicity and their functions in recombinant protein production in yeast

Author: Xin Chen; Xiaowei Li; Boyang Ji; Yanyan Wang; Olena Ishchuk; Egor Vorontsov; Dina Petranovic Nielsen; Verena Siewers; Martin Engqvist

Published: 2022

Published in: Data in Brief

Publication type: Journal article
Saccharomyces cerevisiae as a Heterologous Host for Natural Products

Author: Maximilian Otto; Dany Liu; Verena Siewers

Published: 2022

Published in: Methods in molecular biology (Clifton, N.J.)

Publication type: Journal article
Suppressors of amyloid-β toxicity improve recombinant protein production in yeast by reducing oxidative stress and tuning cellular metabolism

Author: Xin Chen; Xiaowei Li; Boyang Ji; Yanyan Wang; Olena Ishchuk; Egor Vorontsov; Dina Petranovic Nielsen; Verena Siewers; Martin Engqvist

Published: 2022

Published in: Metabolic Engineering

Publication type: Journal article
Identification of a novel gene required for competitive growth at high temperature in the thermotolerant yeast Kluyveromyces marxianus

Author: Noemi Montini; Tyler Doughty; Iván Domenzain Del Castillo Cerecer; Darren A. Fenton; Pavel V. Baranov; Ronan Harrington; Jens B Nielsen; Verena Siewers; John P. Morrissey

Published: 2022

Published in: Microbiology

Publication type: Journal article
Engineering Saccharomyces cerevisiae for the production and secretion of Affibody molecules

Author: Veronica Gast; Anna Sandegren; Finn Dunås; Siri Ekblad; Rezan Güler; Staffan Thorén; Marta Tous Mohedano; Mikael Molin; Martin Engqvist; Verena Siewers

Published: 2022

Published in: Microbial Cell Factories

Publication type: Journal article
A Hypersensitive Genetically Encoded Fluorescent Indicator (roGFP2-Prx1) Enables Continuous Measurement of Intracellular H2O2 during Cell Micro-cultivation

Author: Veronica Gast; Verena Siewers; Mikael Molin

Published: 2022

Published in: Bio-protocol

Publication type: Journal article
2021
Expansion of the Yeast Modular Cloning Toolkit for CRISPR-Based Applications, Genomic Integrations and Combinatorial Libraries

Author: Maximilian Otto; Christos Skrekas; Michael Gossing; Johan Gustafsson; Verena Siewers; Florian David

Published: 2021

Published in: ACS Synthetic Biology

Publication type: Journal article
Rational gRNA design based on transcription factor binding data

Author: David Bergenholm; Yasaman Dabirian; Raphael Ferreira; Verena Siewers; Florian David; Jens B Nielsen

Published: 2021

Published in: Synthetic Biology

Publication type: Journal article
Development of an Haa1-based biosensor for acetic acid sensing in Saccharomyces cerevisiae

Author: Maurizio Mormino; Verena Siewers; Yvonne Nygård

Published: 2021

Published in: FEMS Yeast Research

Publication type: Journal article
A single chromosome strain of S. cerevisiae exhibits diminished ethanol metabolism and tolerance

Author: Tyler Doughty; Rosemary Brown; Fang Chao; Zhongjun Qin; Verena Siewers; Jens B Nielsen

Published: 2021

Published in: BMC Genomics

Publication type: Journal article
The Yeast eIF2 Kinase Gcn2 Facilitates H2O2-Mediated Feedback Inhibition of Both Protein Synthesis and Endoplasmic Reticulum Oxidative Folding during Recombinant Protein Production

Author: Veronica Gast; Kate Campbell; Cecilia Picazo Campos; Martin Engqvist; Verena Siewers; Mikael Molin

Published: 2021

Published in: Applied and Environmental Microbiology

Publication type: Journal article
Expression of antibody fragments in Saccharomyces cerevisiae strains evolved for enhanced protein secretion

Author: Yanyan Wang; Xiaowei Li; Xin Chen; Jens B Nielsen; Dina Petranovic Nielsen; Verena Siewers

Published: 2021

Published in: Microbial Cell Factories

Publication type: Journal article
GTR 2.0: GRNA-tRNA Array and Cas9-NG Based Genome Disruption and Single-Nucleotide Conversion in Saccharomyces cerevisiae

Author: Guiping Gong; Yueping Zhang; Zibai Wang; Luo Liu; Shuobo Shi; Verena Siewers; Qipeng Yuan; Jens B Nielsen; Xu Zhang; Zihe Liu

Published: 2021

Published in: ACS Synthetic Biology

Publication type: Journal article
Transcriptomic response of Saccharomyces cerevisiae to octanoic acid production

Author: Leonie Baumann; Tyler Doughty; Verena Siewers; Jens B Nielsen; E Boles; Mislav Oreb

Published: 2021

Published in: FEMS Yeast Research

Publication type: Journal article
Evaluating accessibility, usability and interoperability of genome-scale metabolic models for diverse yeasts species

Author: Iván Domenzain Del Castillo Cerecer; Feiran Li; Eduard Kerkhoven; Verena Siewers

Published: 2021

Published in: FEMS Yeast Research

Publication type: Review article
Production of 10-methyl branched fatty acids in yeast

Author: Hannah G. Blitzblau; Andrew L. Consiglio; Paulo Teixeira; Donald V. Crabtree; Shuyan Chen; Oliver Konzock; Gamuchirai Chifamba; Austin Su; Annapurna Kamineni; Kyle MacEwen; Maureen Hamilton; Vasiliki Tsakraklides; Jens B Nielsen; Verena Siewers; A. Joe Shaw

Published: 2021

Published in: Biotechnology for Biofuels

Publication type: Journal article
2020
Does co-expression of Yarrowia lipolytica genes encoding Yas1p, Yas2p and Yas3p make a potential alkane-responsive biosensor in Saccharomyces cerevisiae?

Author: Yasaman Dabirian; Christos Skrekas; Florian David; Verena Siewers

Published: 2020

Published in: PLoS ONE

Publication type: Journal article
Deep learning suggests that gene expression is encoded in all parts of a co-evolving interacting gene regulatory structure

Author: Jan Zrimec; Christoph Sebastian Börlin; Filip Buric; Muhammad Azam Sheikh; Rongzhen Chen; Verena Siewers; Vilhelm Verendel; Jens B Nielsen; Mats Töpel; Aleksej Zelezniak

Published: 2020

Published in: Nature Communications

Publication type: Journal article
Different routes of protein folding contribute to improved protein production in saccharomyces cerevisiae

Author: Qi Qi; Feiran Li; Rosemary Yu; Martin Engqvist; Verena Siewers; Johannes Fuchs; Jens B Nielsen

Published: 2020

Published in: mBio

Publication type: Journal article
Promiscuous phosphoketolase and metabolic rewiring enables novel non-oxidative glycolysis in yeast for high-yield production of acetyl-CoA derived products

Author: John Hellgren; Alexei Godina; Jens B Nielsen; Verena Siewers

Published: 2020

Published in: Metabolic Engineering

Publication type: Journal article
The transcription factor Leu3 shows differential binding behavior in response to changing leucine availability

Author: Christoph Sebastian Börlin; Jens B Nielsen; Verena Siewers

Published: 2020

Published in: FEMS Microbiology Letters

Publication type: Journal article
Stress-induced expression is enriched for evolutionarily young genes in diverse budding yeasts

Author: Tyler Doughty; Iván Domenzain Del Castillo Cerecer; Aaron Millan-Oropeza; Noemi Montini; Philip A. de Groot; Rui Pereira; Jens B Nielsen; Céline Henry; J. M. Daran; Verena Siewers; John P. Morrissey

Published: 2020

Published in: Nature Communications

Publication type: Journal article
Adaptive Laboratory Evolution of Ale and Lager Yeasts for Improved Brewing Efficiency and Beer Quality

Author: B. Gibson; M. Dahabieh; K. Krogerus; Paula Jouhten; F. Magalhães; Rui Pereira; Verena Siewers; V. Vidgren

Published: 2020

Published in: Annual review of food science and technology

Publication type: Review article

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Projects
1/1/2022 — 12/31/2025

A flexible bacterial consolidated bioprocess for conversion of plant biomass into short-chain fatty...
Start date : 8/1/2018

Biofuel production with yeast – Boosting alkane production through enzyme engineering
9/1/2019 — 8/31/2023

CRISPRi for elucidating stress regulation in yeast
1/1/2021 — 12/31/2023

Collaboration on Yeast Modelling and Machine Learning
1/1/2022 — 12/31/2025

Development of a platform yeast strain for cytochrome P450-containing pathway
1/1/2018 — 12/31/2022

Jästcell-baserad produktion av isoprenoid-växthormoner
1/1/2022 — 12/31/2026

Livsmedelsingredienser från CO2 med mikrobiella konsortia
8/1/2020 — 6/30/2023

Model-based design of oleaginous yeast strains for production of biofuels and chemicals (Joint...
1/1/2020 — 12/31/2022

Synthetic biology tools for the production of specialized lipids in yeast
Start date : 1/1/2019

Yeast cell factories for advanced biofuels and microbial robustness
Start date : 1/1/2020

Yeast cell factories for advanced biofuels and microbial robustness, part 2
Closed
1/1/2015 — 6/30/2021

Biological Production Systems 2014
1/1/2018 — 12/31/2020

Genetic biosensors for developing better cell factories for production of platform chemicals
7/1/2017 — 3/31/2019

Metabolite biosensors for yeast cell factories
12/1/2016 — 11/30/2020

Model-Based Construction And Optimisation Of Versatile Chassis Yeast Strains For Production Of...
9/1/2013 — 8/31/2017

Yeast Cell Factories: Training Researchers to Apply Modern Post-Genomic Methods In Yeast...
12/1/2019 — 12/31/2021

Yeast-based biosensors for the specific and accessible detection of pathogens and antimicrobial...

Page manager Published: Mon 08 Feb 2021.

Verena Siewers

Major publications

Latest publications

2022

2021

2020

Projects

Closed