Anna Wiktoria Wypijewska Del Nogal

Researcher; Chemistry and Chemical Engineering, Physical Chemistry

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Dr. Anna Wypijewska del Nogal, PhD, is a Postdoctoral Researcher in the Wilhelmsson Group, at the Division of Chemistry and Biochemistry since September 2018. She carries out a project in the frame of the MSCA-IF Fellowship, which aims at studying the interaction of pre-microRNA (pre-miRNA) with other (bio)molecules, using fluorescent base analogs (FBAs) and spectroscopy techniques. This will provide knowledge on pre-miRNA properties as well as function and might help to identify molecules of therapeutic potential for pharma industry. Anna is an active member of the Polish Biophysical Society.

​1. Kowalska J., Wypijewska del Nogal A., Darzynkiewicz Z.M., Buck J., Nicola C., Kuhn A., Lukaszewicz M., Zuberek J., Strenkowska M., Ziemniak M., Maciejczyk M., Bojarska E., Rhoads R.E., Darzynkiewicz E., Sahin U., Jemielity J.: Synthesis, properties and biological activity of boranophosphate analogs of the mRNA cap: versatile tools for manipulation of therapeutically relevant cap-dependent processes. Nucleic Acids Res. 42, 10245-64 (2014);


2. Milac A., Bojarska E., Wypijewska del Nogal A.: Decapping Scavenger (DcpS) enzyme: Advances in its structure, activity and roles in the cap-dependent mRNA metabolism. BBA – Gene Regul. Mech. 1839, 452-62 (2014);


3. Wypijewska del Nogal A., Surleac M.D., Kowalska J., Lukaszewicz M., Jemielity J., Bisaillon M., Darzynkiewicz E., Milac A.L., Bojarska E.: Analysis of decapping scavenger cap complex using modified cap analogs reveals molecular determinants for efficient cap binding. FEBS J. 280, 6508-27 (2013);


4. Wypijewska A., Bojarska E., Lukaszewicz M., Stepinski J., Jemielity J., Davis R.E., Darzynkiewicz E.: 7-methylguanosine diphosphate (m7GDP) is not hydrolyzed but strongly bound by Decapping Scavenger (DcpS) enzymes and potently inhibits their activity. Biochemistry 51, 8003-13 (2012);


5. Wypijewska A., Bojarska E., Stepinski J., Jankowska-Anyszka M., Jemielity J., Davis R.E., Darzynkiewicz E.: Structural requirements for Caenorhabditis elegans DcpS substrates based on fluorescence and HPLC enzyme kinetic studies. FEBS J. 277, 3003-13 (2010);


6. Wypijewska A., Galazka-Friedman J., Bauminger E.R., Wszolek Z.K., Schweitzer K.J., Dickson D.W., Jaklewicz A., Elbaum D., Friedman A.: Iron and reactive oxygen species activity in parkinsonian substantia nigra. Parkinsonism Relat. Disord. 16, 329-33 (2010);


7. Guranowski A., Wojdyla A.M., Zimny J., Wypijewska A., Kowalska J., Jemielity J., Davis R.E., Bieganowski P.: Dual activity of certain HIT-proteins: A. thaliana Hint4 and C. elegans DcpS act on adenosine 5’-phosphosulfate as hydrolases (forming AMP) and as phosphorylases (forming ADP). FEBS Lett. 584, 93-8 (2010);


8. Guranowski A., Wojdyla A.M., Zimny J., Wypijewska A., Kowalska J., Lukaszewicz M., Jemielity J., Darzynkiewicz E., Jagiello A., Bieganowski P.: Recognition of different nucleotidyl-derivatives as substrates of reactions catalyzed by various HIT-proteins. New J. Chem. 34, 888-93 (2010).

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