Systematic Rebuilding of Actinomycetes for Natural Product Formation (ERASysAPP - SYSTERACT)

Despite an increasing medical need, the number of new antibiotics approved for human use has been declining over many years. Recently, new molecular genetics and biochemical tools, and in particular Next Generation Sequencing, combined with newly developed bioinformatics approaches, have provided insight into the enormous unexploited genetic pool of environmental microbial biodiversities for the synthesis of potential new bioactive compounds. The main objective of the SYSTERACT project is through an integrated and interdisciplinary approach to develop the model actinomycete Streptomyces coelicolor into a 'Superhost' for the efficient heterologous production of bioactive compounds, enabling a faster discovery of new antibiotics from environmental microbial resources (microbial strains and metagenomes). Central to this approach will be an iterative Systems Biology process, combining microbiology, genetics, biochemistry, and fermentation technology with modelling.

Partner organizations

  • SINTEF (Private, Norway)
  • University of Rostock (Academic, Germany)
  • Leiden University (Academic, Netherlands)
  • University of Tübingen (Academic, Germany)
Start date 01/09/2015
End date The project is closed: 31/12/2018

Page manager Published: Thu 19 Jul 2018.