Multi-resistant bacteria cause tens of thousands of deaths every year in Europe, jeopardizing all kinds of medical procedures. According to the WHO, the rapid resistance development is one of the largest threats to public health, globally. Alarmingly, not only antibiotics select for resistance, but the combined exposure to biocides and metals can also contribute through co-selection and cross-resistance. Chemicals in the environment may thus make bacteria untreatable with antibiotics at a later stage. To enable mitigations, INTERACT will identify chemicals and environments associated with high risks for combination effects. Specifically, we will assess:
1.What biocides and concentrations that promote resistance development
2.In which environments high-risk mixtures can be found
3.The genetic basis for co- and cross-resistance
4.The potential for resistancefactors to spread from the environment to human pathogens
INTERACT is expected to provide crucial input to environmental regulatory agencies, as well as the health care, water and shipping sectors.