Computational modelling of phospholipids in plasma membranes

Victor Lanai, MPNAT Nanotechnology, presents his master thesis titled
Computational modelling of phospholipids in plasma membranes
 - A dive into the diverse response of bacteria and mammalian cells to graphene"

Supervisor and examiner: Elsebeth Schröder, MC2
The purpose of this project is to investigate if the constituent of phospholipids in plasma membranes effects the cell's interactions with graphene. Researchers have shown that vertically grown graphene flakes are effective in killing bacteria whilst keeping mammalian cells intact. However, the mechanism behind this phenomena is not known, and is at the same time difficult to measure experimentally. Therefore we choose density functional theory as a tool with the goal to enhance the understanding. The project started off by creation of a library of single phospholipids. These were further used to analyze the bonding between different phospholipids and their interaction with graphene. Calculations show that the most abundant phospholipids in human cells have stronger bonding to each other, compared to bacterial phospholipids. The composition of phospholipids may therefore be an important factor to the robustness of microorganisms and their response to graphene flakes. 
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Category Student project presentation
Location: Fasrummet, meeting room, Kemivägen 9, MC2-huset
Starts: 09 June, 2022, 10:00
Ends: 09 June, 2022, 11:00

Page manager Published: Tue 31 May 2022.