The objective of this project is to obtain fundamental understanding of the molecular and biological factors that determine cellular uptake, trafficking and delivery of different types of LNPs and exosomes. This will be accomplished by i) establishing and use microscopy methods for mechanism-of-action (MoA) studies of cellular uptake, intracellular trafficking/recycling and delivery of LNPs / exosomes, and ii) adapt microscopy methods high content imaging to enable screening of effector molecules (AZ libraries).
Lead academic principal investigator: Elin Esbjörner (Chalmers)
Industrial and academic partners: Anna Collén, Shalini Andersson and
Lennart Lindfors (AstraZeneca), Samir El-Andaloussi (Karolinska Institutet), Fredrik Höök and Marcus