For an ambitious and challenging research project as FoRmulaEx to be successful the recruitment process of the researchers that will carry out the main part of the lab work, Postdocs and PhD students, is crucial. We are delighted to have completed this important task and found a group of talented and dedicated researchers to welcome to FoRmulaEx. They are listed and briefly presented below with links to their respective profile pages where you can find more information. With the recruitment process completed, the research activity is high within the project and we look forward to share more updates regarding our scientific achievements going forward.
Chalmers University of Technology
Group of Prof. Fredrik Höök (Department of Physics)
- Dr. Nima Aliakbarinodehi (Postdoc) has a background in microsystems and in the design, fabrication and characterization of biosensors from his PhD studies at École Polytechnique Fédérale de Lausanne, Switzerland. In FoRmulaEx Nima will focus on developing new platforms to study the interaction between RNA-loaded lipid nanoparticles and lipid model membranes to give a deeper insight into the endosomal escape process.
- Mattias Sjöberg (PhD student) has a BSc in Engineering Physics and MSc in Nanotechnology from Chalmers. In his research project within FoRmulaEx he develops new surface-based bioanalytical sensing methods with high sensitivity to characterize biological nanoparticles.
Group of Assoc. Professor Elin Esbjörner Winters (Department of Biology and Biological Engineering)
- Dr. Audrey Gallud (Postdoc) holds a PhD from the Institute of Biomolecules Max Mousseron in Montpellier (France), focused on glyco- and nano-vectors for therapeutic targeting against rare pathologies. Prior to joining FoRmulaEx, Audrey worked at the Karolinska Institutet for 3 years studying the immunotoxicity of engineered nanomaterials. In FoRmulaEx Audrey focuses on how to develop novel technologies that will allow successful translation of RNA modalities into the clinic.
- Dr. Emanuele Celauro (Postdoc) has a background in biology and genetics and pursued his PhD studies at the Sapienza University in Rome, Italy. His research interests and his activities within FoRmulaEx includes endocytosis, vesicular trafficking and intracellular delivery of therapeutic DNA/RNA.
Group of Prof. Marcus Wilhelmsson (Department of Chemistry and Chemical Engineering)
- Dr. Tom Baladi (Postdoc) is an organic chemist that prior to FoRmulaEx pursued his PhD at the Institut Curie / Université Paris-Saclay, Paris, France as well as a one-year Postdoc position at the Institut de Chimie de Nice, Nice, France. In FoRmulaEx, Tom works on the synthesis of fluorescent base analogs and their incorporation into oligonucleotides and RNA. The goal is to follow oligos and RNA in different in vitro setups to enable studies of delivery systems and the fate of these types of drugs.
- Dr. Jesper Nilsson (Postdoc) holds a PhD from Chalmers and in his research, he applies spectroscopy-based techniques to study conformation, dynamics, and protein interactions of nucleic acids, in particular RNA, using fluorescent nucleic acid base analogs. The overall aim of his research is to develop and implement novel tools for studying e.g. cell uptake, intracellular distribution, and target interactions of oligonucleotide-based therapeutics.
University of Gothenburg
Group of Assoc. Professor Hadi Valadi (Inst. Medicine, Dept. Rheumatology and Inflammation)
- Dr. Marco Magueri (Postdoc) holds a PhD in Biology from the University of Catania, Italy. During his PhD studies Marco worked with cancer biology and the mechanisms underlying cancer response to anti-tumoral therapeutics, particularly the exosomal and cellular microRNAs involvement in the progression and the drug response of colorectal cancer and neuroblastoma. Marcos main interest lies in exosomal RNA loading and packaging system, and in FoRmulaEx he studies exosome-based therapeutic RNA delivery.
Group of Professor Molly Stevens (Department of Medical Biochemistry and Biophysics)
- Dr. Miina Ojansivu (Postdoc) has a background in tissue engineering and holds a PhD in osteogenic differentiation mechanisms of human adipose stem cells from the University of Tampere, Finland. Prior to joining FoRmulaEx she was a visiting researcher at University of Bergen developing bioprinting for bone tissue engineering. In FoRmulaEx, Miina focuses on the study of hMSC-derived extracellular vesicles, their role in the process of osteogenic differentiation and the visualization of natural and synthetic vesicles with super-resolution microscopy.
Group of Ass. Professor Samir El-Andaloussi (Dept. Laboratory Medicine)
- Dr. Taavi Lehto (Postdoc) main research interest lies on the development of various drug delivery systems and targeting strategies for different biomacromolecules, including oligonucleotides, and their use in therapeutic applications. Taavi holds a PhD in biomedical enginering from University of Tartu, Estonia and prior to joining FoRmulaEx, he has visited Ludwig Maximilians University Munich as a post-doctoral research fellow as well as Universiry of Tartu as a researcher. In FoRmulaEx, Taavi mainly studies the production, delivery and uptake of extracellular vesicles (labeled, RNA-loaded etc.) over different source and recipient cell lines.
- Jeremy Bost (PhD student), has a background in biochemistry and previous experience from optimization of extracellular vesicle (EV) isolation methods and their influence on EV cargo as well as EV association and interaction with small RNAs. This experience he has gained from internships at the Broad Institute of MIT and Harvard and the University of Oxford. In FoRmulaEx, Jeremys interests lies in the engineering of EVs for loading and targeting as well as the influence of cell source and recipient line on EV uptake kinetics.