News: Centre FoRmulaEx related to Chalmers University of TechnologyWed, 05 Feb 2020 13:07:38 +0100 study on mRNA delivery by exosomes in Nature Communications<p><b>​​An article on mRNA delivery by exosomes has been published in Nature Communications.</b></p>​<div><img src="/SiteCollectionImages/Institutioner/F/Blandade%20dimensioner%20inne%20i%20artikel/Hadi_Valadi.JPG" class="chalmersPosition-FloatRight" alt="" style="margin:5px;width:157px;height:195px" /><span></span><span style="background-color:initial">FoRmulaEx members Associate Professor Hadi Valadi, postdoc Marco Magueri from University of Gothenburg and Lennart Lindforss, Principal Scientist at AstraZeneca have together with colleagues recently published their discoveries on mRNA delivery by exosomes in the prestigious journal Nature Communications. We congratulate them on their inspiring achievement that will be of great use for the continued progress within FoRmulaEx. <br /><br /><a href="" target="_blank"><img class="ms-asset-icon ms-rtePosition-4" src="/_layouts/images/icgen.gif" alt="" />Read an article about the results in Akademiliv</a><br /></span><span style="background-color:initial"><br /><br />Illustration: </span><span style="background-color:initial">iStockPhotos<br />Photo: </span><span style="background-color:initial">Elin Lindström​</span></div>Tue, 04 Feb 2020 00:00:00 +0100 of PhD students and Postdocs completed for 2018<p><b>With the recruitment process completed of 8 Postdocs and 2 PhD students earlier in 2018 the project is fully staffed and the research and collaboration activity in FoRmulaEx is high. Read more about our newly recruited and talented researchers. ​​</b></p><span><p class="chalmersElement-P"><span>For an ambitious and challenging research project as FoRmulaEx to be successful the recruitment process of the researchers that will carry out the main part of the lab work, Postdocs and PhD students, is crucial. We are delighted to have completed this important task and found a group of talented and dedicated researchers to welcome to FoRmulaEx. They are listed and briefly presented below with links to their respective profile pages where you can find more information. With the recruitment process completed, the research activity is high within the project and we look forward to share more updates regarding our scientific achievements going forward.<span style="display:inline-block"></span></span><span style="background-color:initial;color:rgb(51, 51, 51)"><br /></span></p> <h4 class="chalmersElement-H4">Chalmers University of Technology </h4> <p class="chalmersElement-P"><font color="#333333"><strong>Group of Prof. Fredrik Höök</strong> (<em>Department of Physics)</em><br /></font></p> <p class="chalmersElement-P"></p> <ul><li><a href="">Dr. Nima Aliakbarinodehi </a> (Postdoc) has a background in microsystems and in the design, fabrication and characterization of biosensors from his PhD studies at École Polytechnique Fédérale de Lausanne, Switzerland. In FoRmulaEx Nima will focus on developing new platforms to study the interaction between RNA-loaded lipid nanoparticles and lipid model membranes to give a deeper insight into the endosomal escape process.</li></ul> <p></p> <p class="chalmersElement-P"></p> <ul><li><span style="color:rgb(51, 51, 51);background-color:initial"><a href="">Mattias Sjöberg</a> (PhD student) has a BSc in Engineering Physics and MSc in Nanotechnology from Chalmers. In his research project within FoRmulaEx he develops new surface-based bioanalytical sensing methods with high sensitivity to characterize biological nanoparticles. <br /></span><br /></li></ul> <p></p> <p class="chalmersElement-P"><font color="#333333"><strong>Group of Assoc. Professor Elin Esbjörner Winters</strong> <em>(Department of Biology and Biological Engineering)</em><br /></font></p> <p class="chalmersElement-P"></p> <ul><li><a href="/en/staff/Pages/gallud.aspx">Dr. Audrey Gallud</a> (Postdoc) holds a PhD from the Institute of Biomolecules Max Mousseron in Montpellier (France), focused on glyco- and nano-vectors for therapeutic targeting against rare pathologies. Prior to joining FoRmulaEx, Audrey worked at the Karolinska Institutet for 3 years studying the immunotoxicity of engineered nanomaterials. In FoRmulaEx Audrey focuses on how to develop novel technologies that will allow successful translation of RNA modalities into the clinic.</li></ul> <p></p> <p class="chalmersElement-P"></p> <ul><li><a href="/en/staff/Pages/celauro.aspx">Dr. Emanuele Celauro</a> (Postdoc) has a background in biology and genetics and pursued his PhD studies at the Sapienza University in Rome, Italy. His research interests and his activities within FoRmulaEx includes endocytosis, vesicular trafficking and intracellular delivery of therapeutic DNA/RNA.<br /><br /></li></ul> <p></p> <p class="chalmersElement-P"><font color="#333333"><strong>Group of Prof. Marcus Wilhelmsson</strong> (<em>Department of Chemistry and Chemical Engineering)</em></font></p> <p class="chalmersElement-P"></p> <ul><li><a href="/en/Staff/Pages/baladi.aspx">Dr. Tom Baladi</a> (Postdoc) is an organic chemist that prior to FoRmulaEx pursued his PhD at the Institut Curie / Université Paris-Saclay, Paris, France as well as a one-year Postdoc position at the Institut de Chimie de Nice, Nice, France. In FoRmulaEx, Tom works on the synthesis of fluorescent base analogs and their incorporation into oligonucleotides and RNA. The goal is to follow oligos and RNA in different in vitro setups to enable studies of delivery systems and the fate of these types of drugs. </li></ul> <p class="chalmersElement-P"></p> <ul><li><a href="/en/Staff/Pages/Jesper-Nilsson.aspx">Dr. Jesper Nilsson </a> (Postdoc) holds a PhD from Chalmers and in his research, he applies spectroscopy-based techniques to study conformation, dynamics, and protein interactions of nucleic acids, in particular RNA, using fluorescent nucleic acid base analogs. The overall aim of his research is to develop and implement novel tools for studying e.g. cell uptake, intracellular distribution, and target interactions of oligonucleotide-based therapeutics.<br /></li></ul> <p></p> <p class="chalmersElement-P"><font color="#333333"><br /></font></p> <h4 class="chalmersElement-H4">University of Gothenburg</h4> <p class="chalmersElement-P"><font color="#333333"><strong>Group of Assoc. Professor Hadi Valadi</strong> (<em>Inst. Medicine, Dept. Rheumatology and Inflammation</em>)</font></p> <p class="chalmersElement-P"></p> <ul><li><a href=";departmentId=035540">Dr. Marco Magueri</a> (Postdoc) holds a PhD in Biology from the University of Catania, Italy. During his PhD studies Marco worked with cancer biology and the mechanisms underlying cancer response to anti-tumoral therapeutics, particularly the exosomal and cellular microRNAs involvement in the progression and the drug response of colorectal cancer and neuroblastoma. Marcos main interest lies in exosomal RNA loading and packaging system, and in FoRmulaEx he studies exosome-based therapeutic RNA delivery.<br /></li></ul> <font color="#333333"><br /></font><p></p> <h4 class="chalmersElement-H4">Karolinska Institutet</h4> <p class="chalmersElement-P"><font color="#333333"><strong>Group of Professor Molly Stevens</strong> (<em>Department of Medical Biochemistry and Biophysics</em>)</font></p> <p class="chalmersElement-P"></p> <ul><li><a href=""> Dr. Miina Ojansivu</a> (Postdoc) has a background in tissue engineering and holds a PhD in osteogenic differentiation mechanisms of human adipose stem cells from the University of Tampere, Finland. Prior to joining FoRmulaEx she was a visiting researcher at University of Bergen developing bioprinting for bone tissue engineering. In FoRmulaEx, Miina focuses on the study of hMSC-derived extracellular vesicles, their role in the process of osteogenic differentiation and the visualization of natural and synthetic vesicles with super-resolution microscopy. </li></ul> <p></p> <p class="chalmersElement-P"><font color="#333333"><strong>Group of Ass. Professor Samir El-Andaloussi</strong> (Dept. Laboratory Medicine)</font></p> <p class="chalmersElement-P"></p> <ul><li><a href="">Dr. Taavi Lehto</a> (Postdoc) main research interest lies on the development of various drug delivery systems and targeting strategies for different biomacromolecules, including oligonucleotides, and their use in therapeutic applications. Taavi holds a PhD in biomedical enginering from University of Tartu, Estonia and prior to joining FoRmulaEx, he has visited Ludwig Maximilians University Munich as a post-doctoral research fellow as well as Universiry of Tartu as a researcher. In FoRmulaEx, Taavi mainly studies the production, delivery and uptake of extracellular vesicles (labeled, RNA-loaded etc.) over different source and recipient cell lines. </li></ul> <p></p> <p class="chalmersElement-P"><font color="#333333"><span style="background-color:initial"></span></font></p> <p class="chalmersElement-P"></p> <ul><li><a href="">Jeremy Bost </a> (PhD student), has a background in biochemistry and previous experience from optimization of extracellular vesicle (EV) isolation methods and their influence on EV cargo as well as EV association and interaction with small RNAs. This experience he has gained from internships at the Broad Institute of MIT and Harvard and the University of Oxford. In FoRmulaEx, Jeremys interests lies in the engineering of EVs for loading and targeting as well as the influence of cell source and recipient line on EV uptake kinetics. </li></ul></span><div><br /><a href="/en/centres/FoRmulaEx/about/Pages/default.aspx"><img class="ms-asset-icon ms-rtePosition-4" src="/_layouts/images/ichtm.gif" alt="" />Read more about the industrial research centre Formulaex </a><br /></div>Fri, 01 Mar 2019 09:00:00 +0100 MSEK for developing target seeking biological pharmaceuticals<p><b>​The Swedish Foundation for Strategic Research (SSF) invests 75 million SEK in an industrial research centre managed by Chalmers Professor Fredrik Höök. The project focuses on encapsulating biological pharmaceuticals into nanoscale carriers in order to reach the body’s cells and treat severe diseases.</b></p>​<span><img src="/SiteCollectionImages/Institutioner/F/Blandade%20dimensioner%20inne%20i%20artikel/Fredrik_Hook_300x350px.jpg" class="chalmersPosition-FloatRight" alt="" style="height:290px;width:250px;margin:5px" /><span style="display:inline-block"></span></span>&quot;A promising candidate for treating today’s incurable diseases is to reprogram the cells. However, since the reprogramming must take place inside the cell the pharmaceutical must penetrate the cell membrane. Designing and encapsulating biological molecules in nanocarriers so that they are capable of this is very challenging. That’s why it’s important with a broad-scale collaboration between the academia and the industry, says Fredrik Höök, Professor in biological physics at the Department of Physics at Chalmers and academic leader for Formulaex. <br /><br />The industrial research centre will focus on so called nucleotide-based therapeutics and in the consortium Chalmers collaborates with the lead industrial partner Astra Zeneca as well as Camurus, Vironova, Gothenburg Sensor Devices and the academic partners Karolinska Institute and University of Gothenburg. <br /><br />The centre will study fundamental requirements for pharmaceuticals made from biological molecules like DNA and RNA – the code that is the foundation for how cells work. Present research on the improvement of pharmaceuticals’ transportation into a cell is based on fabricating nanoparticles which mimic naturally occurring processes in the human body. Cells can, for instance, communicate by exchange of nanocarriers.<br /><br />“I am looking forward to the new dimension this project will add to our ongoing research, which has potential value far outside this team of academic and industrial partners. The assembled excellence of the industry and the academia can hopefully generate a great benefit for society. We also hope that our region will become even more attractive within Life science”, says Fredrik Höök. <br /><br />Within the Chalmers’ team there are two more members: Professor Marcus Wilhelmsson at the Department of Chemistry and Chemical Engineering and Associate Professor Elin Esbjörner at the Department of Biology and Biological Engineering. <br /><br />The project “Functional delivery of nucleotide based therapeutics” will run for six to eight years and give a better understanding of the process of cellular uptake and endosomal escape of nucleotide based therapeutics. The work includes development of advanced analytical methods, biomolecular design, cell studies and development of nanocarriers and delivery of new genetic bases therapeutics.  <br /><br />Text: Mia Halleröd Palmgren,<br /><br /><strong>Contact: </strong><br />Fredrik Höök, Academic leader, Professor at the Department of Physics, Chalmers, 0708-95 12 39,<br /><br /><strong>More information: </strong><br /><br /><a href=""><img src="/_layouts/images/icgen.gif" class="ms-asset-icon ms-rtePosition-4" alt="" />Read the press release from The Swedish Foundation for Strategic Researc</a>h (in Swedish) <br /><a href="/en/departments/physics/news/Pages/A-Chalmers-innovation-paves-the-way-for-the-next-generation-of-pharmaceuticals.aspx"><img src="/_layouts/images/ichtm.gif" class="ms-asset-icon ms-rtePosition-4" alt="" />Read more about the research of Fredrik Höök. </a><br /><a href="/en/departments/physics/news/Pages/A-Chalmers-innovation-paves-the-way-for-the-next-generation-of-pharmaceuticals.aspx"></a><br /><span><span>Note: 75 MSEK equals approximately 7.9 MEUR (9 February 2017)<span style="display:inline-block"></span></span></span><br />Wed, 08 Feb 2017 00:00:00 +0100