Abstract
Recent developments in electrochemical enzyme biosensors have been primarily concerned with nanostructuring of the sensor modifier layers in order to optimize performance. This has included addressing the questions of the necessity of redox mediator and how to incorporate it effectively in the biosensor assembly, the use of nanostructured materials to enhance performance and the reduction of response times by improving diffusion or reducing diffusion lengths.
Nanostructured modified electrodes, using different forms of carbon substrate, have been developed based on polyazine redox mediator films, incorporation of carbon nanotubes and with cross-linking, chitosan or oxysilane sol-gel to retain the enzymes and layer-by-layer self-assembly has been explored. Electrocatalytic and synergistic effects in oxidase-based biosensors between redox mediator films and carbon nanotubes have been probed and recent results include evidence for unmediated, in addition to mediated, electron transfer. These questions will be discussed and applications to clinical and food samples illustrated.
Host: Andy Ewing
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