Fredrik Westerlund

Professor; Biology and Biological Engineering
Head of Division of Chemical Biology

fredrik.westerlund@chalmers.se +46317723049 Find me http://orcid.org/0000-0002-4767-4868

Fredrik Westerlund's research is devoted to studying single DNA molecules in nanofluidic channels using fluorescence microscopy. Focus is directed both towards developing new techniques to map DNA sequences as well as for studying DNA-protein interactions.

Westerlunds Research Group

Publications - ResearcherID

Teaching
Publications
Collaboration and projects

Biophysical chemistry (KFK021), Lecturer

Latest publications

2020
Stabilization of G-quadruplex DNA structures in Schizosaccharomyces pombe causes single-strand DNA lesions and impedes DNA replication

Author: Ikenna Obi; Matilda Rentoft; Vandana Singh; Jan Jamroskovic; Karam Chand; E. Chorell; Fredrik Westerlund; Nasim Sabouri

Published: 2020

Published in: Nucleic Acids Research

Publication type: Journal article
Real-time compaction of nanoconfined DNA by an intrinsically disordered macromolecular counterion

Author: Rajhans Sharma; Sriram Kk; Erik D. Holmstrom; Fredrik Westerlund

Published: 2020

Published in: Biochemical and Biophysical Research Communications

Publication type: Journal article
Phosphorylated CtIP bridges DNA to promote annealing of broken ends

Author: Robin Öz; Sean Howard; Rajhans Sharma; Hanna Törnkvist; Ilaria Ceppi; Sriram Kesarimangalam; Erik Kristiansson; Petr Cejka; Fredrik Westerlund

Published: 2020

Published in: Proceedings of the National Academy of Sciences of the United States of America

Publication type: Journal article
Quantifying DNA damage induced by ionizing radiation and hyperthermia using single DNA molecule imaging

Author: Vandana Singh; Pegah Johansson; Dmitry Torchinsky; Yii Lih Lin; Robin Öz; Y. Ebenstein; Ola Hammarsten; Fredrik Westerlund

Published: 2020

Published in: Translational Oncology

Publication type: Journal article
Molecular Epidemiology of OXA-48 and NDM-1 Producing Enterobacterales Species at a University Hospital in Tehran, Iran, Between 2015 and 2016

Author: Hamid Solgi; Shoeib Nematzadeh; Christian G. Giske; Farzad Badmasti; Fredrik Westerlund; Yii Lih Lin; Gaurav Goyal; Vajihe Sadat Nikbin; Amir Hesam Nemati; Fereshteh Shahcheraghi

Published: 2020

Published in: Frontiers in Microbiology

Publication type: Journal article
Cultivation-Free Typing of Bacteria Using Optical DNA Mapping

Author: Vilhelm Müller; My Nyblom; Anna Johnning; Marie Wrande; Albertas Dvirnas; Sriram Kesarimangalam; Christian G. Giske; Tobias Ambjörnsson; L. Sandegren; Erik Kristiansson; Fredrik Westerlund

Published: 2020

Published in: ACS Infectious Diseases

Publication type: Journal article
Lipid vesicle composition influences the incorporation and fluorescence properties of the lipophilic sulphonated carbocyanine dye SP-DiO

Author: Quentin Lubart; Jonas Hannestad; Hudson Pace; Daniel Fjällborg; Fredrik Westerlund; Elin Esbjörner Winters; Marta Bally

Published: 2020

Published in: Physical Chemistry Chemical Physics

Publication type: Journal article
A Nanofluidic Device for Multiplexed Analysis of Single Exosomes

Author: Quentin Lubart; Sune Levin; Stephan Block; Silver Jõemetsa; Sriram Kesarimangalam; Fredrik Höök; Marta Bally; Fredrik Westerlund; Elin Esbjörner Winters

Published: 2020

Published in:

Publication type: Conference contribution
Studying the Intramolecular Forces of Base-Modified Nucleic Acids using Optical Tweezers

Author: Vinoth Sundar Rajan; Xavier Viader; Yii Lih Lin; Felix Ritort; Fredrik Westerlund; Marcus Wilhelmsson

Published: 2020

Published in:

Publication type: Conference poster
Effect of Chirality on the Elastic Properties of the DNA-Threading Binuclear Ruthenium Complex

Author: Adam A. Jabak; Nicholas Bryden; Fredrik Westerlund; Per Lincoln; Micah J. McCauley; Ioulia F. Rouzina; Mark C. Williams; Thayaparan Paramanathan

Published: 2020

Published in: Biophysical Journal

Publication type: Paper in proceedings
Identifying Evolutionarily Conserved Features of NHEJ from Prokaryotes to Eukaryotes using Single-Molecule Approaches

Author: Robin Öz; Rajhans Sharma; Sriram Kesarimangalam; Fredrik Westerlund

Published: 2020

Published in:

Publication type: Conference contribution
Real-Time Condensation of Nanoconfined DNA by an Intrinsically Disordered Polycationic Protein

Author: Rajhans Sharma; Sriram Kesarimangalam; Erik D. Holmstrom; Fredrik Westerlund

Published: 2020

Published in: Biophysical Journal

Publication type: Paper in proceedings
DNA Bridging by the Homologous Recombination Component CtIP Investigated on the Single DNA Molecule Level

Author: Robin Öz; Sriram Kesarimangalam; Fredrik Westerlund

Published: 2020

Published in:

Publication type: Conference contribution
2019
Bacterial identification by optical mapping of genomic DNA in nanofluidic channels

Author: My Nyblom; Vilhelm Müller; Anna Johnning; Marie Wrande; Albertas Dvirnas; Sriram Kesarimangalam; Christian G. Giske; Tobias Ambjörnsson; L. Sandegren; Erik Kristiansson; Fredrik Westerlund

Published: 2019

Published in: 23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019

Publication type: Paper in proceedings
Optical DNA mapping using nanochannels for identification of plasmids carrying carbapenemase blandm-1 gene from patients admitted to a Vietnamese hospital

Author: Sriram Kesarimangalam; Maud Nilsson; Björn Berglund; Linus Olson; Hoang Bich Ngoc; Tran Minh Dien; Mattias Larsson; Håkan Hanberger; Christian G. Giske; Fredrik Westerlund

Published: 2019

Published in: 23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019

Publication type: Paper in proceedings
Multiplexed optical DNA mapping to identify plasmids and their resistance genes in fecal samples

Author: Sriram Kesarimangalam; Yii Lih Lin; Tsegaye Sewunet; Shoeib Nematzadeh; Christian G. Giske; Fredrik Westerlund

Published: 2019

Published in: 23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019

Publication type: Paper in proceedings
Developing an optical DNA mapping toolbox to identify chromosomal translocations in acute myeloid leukemia

Author: Miriam Hitz; Gaurav Goyal; Vilhelm Müller; Linda Fogelstrand; Fredrik Westerlund

Published: 2019

Published in: 23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019

Publication type: Paper in proceedings
A nanofluidic device for parallel single nanoparticle catalysis in solution

Author: Sune Levin; Joachim Fritzsche; Sara Nilsson; August Runemark; Bhausaheb Kashinath Dhokale; Henrik Ström; Henrik Sundén; Christoph Langhammer; Fredrik Westerlund

Published: 2019

Published in: Nature Communications

Publication type: Journal article
Optical DNA Mapping Combined with Cas9-Targeted Resistance Gene Identification for Rapid Tracking of Resistance Plasmids in a Neonatal Intensive Care Unit Outbreak

Author: Santosh Kumar Bikarolla; Viveka Nordberg; Fredrika Rajer; Vilhelm Müller; Muhammad Humaun Kabir; Sriram Kesarimangalam; Albertas Dvirnas; Tobias Ambjornsson; Christian G. Giske; Lars Navér; Linus Sandegren; Fredrik Westerlund

Published: 2019

Published in: mBio

Publication type: Journal article
Alpha-Synuclein Binds to DNA and Modulates its Physical Properties

Author: Kai Jiang; Sandra Rocha; Alvina Westling; Sriram Kesarimangalam; Kevin D. Dorfman; Pernilla Wittung Stafshede; Fredrik Westerlund

Published: 2019

Published in: Biophysical Journal

Publication type: Paper in proceedings
Annealing of ssDNA and compaction of dsDNA by the HIV-1 nucleocapsid and Gag proteins visualized using nanofluidic channels

Author: Kai Jiang; Nicolas Humbert; Sriram Kesarimangalam; Thiebault Lequeu; Yii Lih Lin; Yves Mely; Fredrik Westerlund

Published: 2019

Published in: Quarterly Reviews of Biophysics

Publication type: Journal article
A nanofluidic device for real-time visualization of DNA-protein interactions on the single DNA molecule level

Author: Robin Öz; Sriram Kesarimangalam; Fredrik Westerlund

Published: 2019

Published in: Nanoscale

Publication type: Journal article
Interspecies plasmid transfer appears rare in sequential infections with extended-spectrum β-lactamase (ESBL)-producing Enterobacteriaceae

Author: Anna Lindblom; Sriram Kesarimangalam; Vilhelm Müller; Robin Öz; Hilda Sandström; Christina M. Åhrén; Fredrik Westerlund; Nahid Karami

Published: 2019

Published in: Diagnostic Microbiology and Infectious Disease

Publication type: Journal article
A nanofluidic device for real-time visualization of DNA-protein interactions on the single DNA molecule level

Author: Robin Öz; Sriram Kk; Fredrik Westerlund

Published: 2019

Published in: Nanoscale

Publication type: Journal article
Genetic variation in the conjugative plasmidome of a hospital effluent multidrug resistant Escherichia coli strain

Author: Catarina Ferreira; D. Bogas; Santosh K. Bikarolla; Ana Rita Varela; Karolin Frykholm; Raquel Linheiro; O. C. Nunes; Fredrik Westerlund; C. M. Manaia

Published: 2019

Published in: Chemosphere

Publication type: Journal article

Go to Chalmers publication library

Projects
1/1/2020 — 12/31/2022

Förbättrad cancerbehandling av barn känsliga för DNA-skador
1/1/2020 — 12/31/2022

Förbättrad diagnos av akut leukemi hos barn
1/1/2020 — 12/31/2022

Identification of bacterial infections and antibiotic resistance in low income countries by rapid...
1/1/2018 — 12/31/2020

Individanpassning av cancerbehandling med cellgifter genom direkt mätning av DNA-skador
4/1/2018 — 12/31/2020

Plasmididentifikation och -detektion i Sydostasien - Enterobacteriaceae resistenta mot sista...
4/1/2020 — 3/31/2025

nanoDNArepair
Closed
1/1/2012 — 12/31/2015

A nanofluidic platform for single molecule biophysics
8/1/2017 — 7/31/2019

A novel ultrafast method for detecting multiresistant bacteria in intensive care units
12/1/2019 — 9/30/2020

Basal oxidative damage level assay (BODLA)
1/1/2017 — 12/31/2019

Bärbar diagnostik för sjukdom och antibiotikaresistans med fokus på malaria och bakterieinfektioner
11/1/2016 — 4/30/2018

Characterization of bacterial plasmids on a smartphone
6/1/2015 — 12/31/2019

Genomic diagnostics beyond the sequence (BeyondSeq)
1/1/2017 — 12/31/2019

Mätning av DNA-skador som ett sätt att individanpassa cancerbehandling med cellgifter
1/1/2014 — 12/31/2016

Nanofluidics for ultrafast diagnosis of bacterial infections (NanoDiaBac)
1/1/2015 — 12/31/2016

Odlingsfri identifiering av antibiotikaresistens
7/1/2016 — 12/31/2018

Studier av DNA-reparation på enskilda DNA-molekyler

Published: Tue 01 Sep 2020.

Fredrik Westerlund

Latest publications

2020

2019

Projects

Closed