Fredrik Westerlund

Professor; Biology and Biological Engineering
Head of Division of Chemical Biology

fredrik.westerlund@chalmers.se +46317723049 Find me http://orcid.org/0000-0002-4767-4868

Fredrik Westerlund's research is devoted to studying single DNA molecules in nanofluidic channels using fluorescence microscopy. Focus is directed both towards developing new techniques to map DNA sequences as well as for studying DNA-protein interactions.

Westerlunds Research Group

Publications - ResearcherID

Teaching
Publications
Collaboration and projects

Biophysical chemistry (KFK021), Lecturer

Major publications
Single Particle Nanoplasmonic Sensing in Individual Nanofluidic Channels

Author: Joachim Fritzsche; David Albinsson; Michael Fritzsche; Tomasz Antosiewicz; Fredrik Westerlund; Christoph Langhammer

Published: 2016

Published in: Nano Letters

Publication type: Journal article
DNA compaction by the bacteriophage protein Cox studied on the single DNA molecule level using nanofluidic channels

Author: Karolin Frykholm; Ronnie Berntsson; M. Claesson; Laura De Battice; R. Odegrip; P. Stenmark; Fredrik Westerlund

Published: 2016

Published in: Nucleic Acids Research

Publication type: Journal article
Direct identification of antibiotic resistance genes on single plasmid molecules using CRISPR/Cas9 in combination with optical DNA mapping.

Author: Vilhelm Müller; Fredrika Rajer; Karolin Frykholm; Lena Nyberg; Mahmood Saair Quaderi; Joachim Fritzsche; Erik Kristiansson; T. Ambjornsson; L. Sandegren; Fredrik Westerlund

Published: 2016

Published in: Scientific Reports

Publication type: Journal article
Latest publications

2020
Identifying Evolutionarily Conserved Features of NHEJ from Prokaryotes to Eukaryotes using Single-Molecule Approaches

Author: Robin Öz; Rajhans Sharma; Sriram Kesarimangalam; Fredrik Westerlund

Published: 2020

Published in: Biophysical Journal

Publication type: Paper in proceedings
Real-Time Condensation of Nanoconfined DNA by an Intrinsically Disordered Polycationic Protein

Author: Rajhans Sharma; Sriram Kesarimangalam; Fredrik Westerlund

Published: 2020

Published in: Biophysical Journal

Publication type: Paper in proceedings
DNA Bridging by the Homologous Recombination Component CtIP Investigated on the Single DNA Molecule Level

Author: Robin Öz; Sriram Kesarimangalam; Fredrik Westerlund

Published: 2020

Published in: Biophysical Journal

Publication type: Paper in proceedings
2019
A nanofluidic device for parallel single nanoparticle catalysis in solution

Author: Sune Levin; Joachim Fritzsche; Sara Nilsson; August Runemark; Bhausaheb Kashinath Dhokale; Henrik Ström; Henrik Sundén; Christoph Langhammer; Fredrik Westerlund

Published: 2019

Published in: Nature Communications

Publication type: Journal article
Optical DNA Mapping Combined with Cas9-Targeted Resistance Gene Identification for Rapid Tracking of Resistance Plasmids in a Neonatal Intensive Care Unit Outbreak

Author: Santosh Kumar Bikarolla; Viveka Nordberg; Fredrika Rajer; Vilhelm Müller; Muhammad Humaun Kabir; Sriram Kesarimangalam; Albertas Dvirnas; Tobias Ambjornsson; Christian G. Giske; Lars Navér; Linus Sandegren; Fredrik Westerlund

Published: 2019

Published in: mBio

Publication type: Journal article
Enzyme-free optical DNA mapping of the human genome using competitive binding

Author: Vilhelm Müller; Albertas Dvirnas; John Andersson; Vandana Singh; Sriram Kesarimangalam; Pegah Johansson; Y. Ebenstein; Tobias Ambjornsson; Fredrik Westerlund

Published: 2019

Published in: Nucleic Acids Research

Publication type: Journal article
Alpha-Synuclein Binds to DNA and Modulates its Physical Properties

Author: Kai Jiang; Sandra Rocha; Alvina Westling; Sriram Kesarimangalam; Kevin D. Dorfman; Pernilla Wittung Stafshede; Fredrik Westerlund

Published: 2019

Published in: Biophysical Journal

Publication type: Paper in proceedings
Annealing of ssDNA and compaction of dsDNA by the HIV-1 nucleocapsid and Gag proteins visualized using nanofluidic channels

Author: Kai Jiang; Nicolas Humbert; Sriram Kesarimangalam; Thiebault Lequeu; Yii Lih Lin; Yves Mely; Fredrik Westerlund

Published: 2019

Published in: Quarterly Reviews of Biophysics

Publication type: Journal article
A nanofluidic device for real-time visualization of DNA-protein interactions on the single DNA molecule level

Author: Robin Öz; Sriram Kesarimangalam; Fredrik Westerlund

Published: 2019

Published in: Nanoscale

Publication type: Journal article
Interspecies plasmid transfer appears rare in sequential infections with extended-spectrum β-lactamase (ESBL)-producing Enterobacteriaceae

Author: Anna Lindblom; Sriram Kesarimangalam; Vilhelm Müller; Robin Öz; Hilda Sandström; Christina M. Åhrén; Fredrik Westerlund; Nahid Karami

Published: 2019

Published in: Diagnostic Microbiology and Infectious Disease

Publication type: Journal article
A nanofluidic device for real-time visualization of DNA-protein interactions on the single DNA molecule level

Author: Robin Öz; Sriram Kk; Fredrik Westerlund

Published: 2019

Published in: Nanoscale

Publication type: Journal article
Genetic variation in the conjugative plasmidome of a hospital effluent multidrug resistant Escherichia coli strain

Author: Catarina Ferreira; D. Bogas; Santosh K. Bikarolla; Ana Rita Varela; Karolin Frykholm; Raquel Linheiro; O. C. Nunes; Fredrik Westerlund; C. M. Manaia

Published: 2019

Published in: Chemosphere

Publication type: Journal article
2018
Nanofluidic optical DNA mapping for rapid identification of antibiotics resistant plasmids

Author: Yii Lih Lin; Tsegaye Sewunet; Sriram Kesarimangalam; Christian G. Giske; Fredrik Westerlund

Published: 2018

Published in: 22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2018

Publication type: Paper in proceedings
A Nanofluidic Device for Real-Time Visualization of DNA-Protein Interactions on the Single DNA Molecule Level

Author: Robin Öz; Sriram Kesarimangalam; Fredrik Westerlund

Published: 2018

Published in: Biophysical Journal

Publication type: Journal article
The resistomes of six carbapenem-resistant pathogens - a critical genotype-phenotype analysis

Author: Anna Johnning; N. Karami; Erika Tång Hallbäck; Vilhelm Müller; Lena Nyberg; Mariana Buongermino Pereira; Callum L. Stewart; Tobias Ambjörnsson; Fredrik Westerlund; Ingegerd Adlerberth; Erik Kristiansson

Published: 2018

Published in: Microbial Genomics

Publication type: Journal article
Stochastic unfolding of nanoconfined DNA: Experiments, model and Bayesian analysis

Author: Jens Krog; Mohammadreza Alizadehheidari; Erik Werner; Santosh Kumar Bikarolla; Jonas O. Tegenfeldt; Bernhard Mehlig; Michael A. Lomholt; Fredrik Westerlund; Tobias Ambjornsson

Published: 2018

Published in: Journal of Chemical Physics

Publication type: Journal article
Alpha-Synuclein Modulates the Physical Properties of DNA

Author: Kai Jiang; Sandra Rocha; Alvina Westling; Sriram Kesarimangalam; Kevin D. Dorfman; Pernilla Wittung Stafshede; Fredrik Westerlund

Published: 2018

Published in: Chemistry - A European Journal

Publication type: Journal article
Bacterial response to graphene oxide and reduced graphene oxide integrated in agar plates

Author: Venkata Raghavendra Subrahmanya Sar Mokkapati; Santosh Pandit; JinHo Kim; Anders Mårtensson; Martin Lovmar; Fredrik Westerlund; Ivan Mijakovic

Published: 2018

Published in: Royal Society Open Science

Publication type: Journal article
Hairpins in the conformations of a confined polymer

Author: E. Werner; A. Jain; A. Muralidhar; Karolin Frykholm; T. St Clere Smithe; Joachim Fritzsche; Fredrik Westerlund; K. D. Dorfman; B. Mehlig

Published: 2018

Published in: Biomicrofluidics

Publication type: Journal article
Vertically Aligned Graphene Coating is Bactericidal and Prevents the Formation of Bacterial Biofilms

Author: Santosh Pandit; Z. Cao; Venkata Raghu Mokkapati; Emanuele Celauro; Avgust Yurgens; Martin Lovmar; Fredrik Westerlund; Jie Sun; Ivan Mijakovic

Published: 2018

Published in: Advanced Materials Interfaces

Publication type: Journal article
Reshaping the Energy Landscape Transforms the Mechanism and Binding Kinetics of DNA Threading Intercalation

Author: Andrew G. Clark; M. Nabuan Naufer; Fredrik Westerlund; Per Lincoln; I. Rouzina; T. Paramanathan; Mark C. Williams

Published: 2018

Published in: Biochemistry

Publication type: Journal article
Fluorescence microscopy of nanochannel-confined DNA

Author: Fredrik Westerlund; F. Persson; Joachim Fritzsche; J. P. Beech; J. O. Tegenfeldt

Published: 2018

Published in: Methods in Molecular Biology

Publication type: Book chapter

Go to Chalmers publication library

Projects
12/1/2019 — 9/30/2020

Basal oxidative damage level assay (BODLA)
1/1/2020 — 12/31/2022

Förbättrad diagnos av akut leukemi hos barn
1/1/2018 — 12/31/2020

Individanpassning av cancerbehandling med cellgifter genom direkt mätning av DNA-skador
4/1/2018 — 12/31/2020

Plasmididentifikation och -detektion i Sydostasien - Enterobacteriaceae resistenta mot sista...
4/1/2020 — 3/31/2025

nanoDNArepair
Closed
1/1/2012 — 12/31/2015

A nanofluidic platform for single molecule biophysics
8/1/2017 — 7/31/2019

A novel ultrafast method for detecting multiresistant bacteria in intensive care units
1/1/2017 — 12/31/2019

Bärbar diagnostik för sjukdom och antibiotikaresistans med fokus på malaria och bakterieinfektioner
11/1/2016 — 4/30/2018

Characterization of bacterial plasmids on a smartphone
6/1/2015 — 12/31/2019

Genomic diagnostics beyond the sequence (BeyondSeq)
1/1/2017 — 12/31/2019

Mätning av DNA-skador som ett sätt att individanpassa cancerbehandling med cellgifter
1/1/2014 — 12/31/2016

Nanofluidics for ultrafast diagnosis of bacterial infections (NanoDiaBac)
1/1/2015 — 12/31/2016

Odlingsfri identifiering av antibiotikaresistens
7/1/2016 — 12/31/2018

Studier av DNA-reparation på enskilda DNA-molekyler

Published: Thu 07 Mar 2019.

Fredrik Westerlund

Major publications

Latest publications

2020

2019

2018

Projects

Closed