Fredrik Westerlund

Professor; Biology and Biological Engineering
Head of Division of Chemical Biology

fredrik.westerlund@chalmers.se +46317723049 Find me http://orcid.org/0000-0002-4767-4868

Fredrik Westerlund's research is devoted to studying single DNA molecules in nanofluidic channels using fluorescence microscopy. Focus is directed both towards developing new techniques to map DNA sequences as well as for studying DNA-protein interactions.

Westerlunds Research Group

Publications - ResearcherID

Teaching
Publications
Collaboration and projects

Biophysical chemistry (KFK021), Lecturer

Latest publications

2022
Nanofluidics for single DNA molecule analysis of DNA repair

Author: Fredrik Westerlund

Published: 2022

Published in: Biophysical Journal

Publication type: Other text in scientific journal
Quantification of single-strand DNA lesions caused by the topoisomerase II poison etoposide using single DNA molecule imaging

Author: Vandana Singh; Pegah Johansson; Elina Ekedahl; Yii Lih Lin; Ola Hammarsten; Fredrik Westerlund

Published: 2022

Published in: Biochemical and Biophysical Research Communications

Publication type: Journal article
High diversity of blaNDM-1-encoding plasmids in Klebsiella pneumoniae isolated from neonates in a Vietnamese hospital

Author: Sriram Kesarimangalam; Elina Ekedahl; Ngoc Thi Bich Hoang; Tsegaye Sewunet; Björn Berglund; Ludwig Lundberg; Shoeib Nematzadeh; Maud Nilsson; Lennart E. Nilsson; Ngai Kien Le; Tran Minh Dien; Håkan Hanberger; Linus Olson; Mattias Larsson; Christian G. Giske; Fredrik Westerlund

Published: 2022

Published in: International Journal of Antimicrobial Agents

Publication type: Journal article
2021
Polyclonal spread of blaCTX-M-15 through high-risk clones of Escherichia coli at a tertiary hospital in Ethiopia

Author: Tsegaye Sewunet; Daniel Asrat; Yimtubezinash Woldeamanuel; Sofia Ny; Fredrik Westerlund; Abraham Aseffa; Christian G. Giske

Published: 2021

Published in: Journal of Global Antimicrobial Resistance

Publication type: Journal article
Combining dense and sparse labeling in optical DNA mapping

Author: Erik Torstensson; Gaurav Goyal; Anna Johnning; Fredrik Westerlund; Tobias Ambjörnsson

Published: 2021

Published in: PLoS ONE

Publication type: Journal article
Click and Cut: a click chemistry approach to developing oxidative DNA damaging agents

Author: Natasha McStay; Creina Slator; Vandana Singh; Alex Gibney; Fredrik Westerlund; Andrew Kellett

Published: 2021

Published in: Nucleic Acids Research

Publication type: Journal article
Detection of structural variations in densely-labelled optical DNA barcodes: A hidden Markov model approach

Author: Albertas Dvirnas; Callum L. Stewart; Vilhelm Müller; Santosh Kumar Bikarolla; Karolin Frykholm; L. Sandegren; Erik Kristiansson; Fredrik Westerlund; Tobias Ambjörnsson

Published: 2021

Published in: PLoS ONE

Publication type: Journal article
A parallelized nanofluidic device for high-throughput optical dna mapping of bacterial plasmids

Author: Sriram Kesarimangalam; Yii Lih Lin; Tsegaye Sewunet; Marie Wrande; L. Sandegren; Christian G. Giske; Fredrik Westerlund

Published: 2021

Published in: Micromachines

Publication type: Journal article
High prevalence of bla(CTX-M-15) and nosocomial transmission of hypervirulent epidemic clones of Klebsiella pneumoniae at a tertiary hospital in Ethiopia

Author: Tsegaye Sewunet; Daniel Asrat; Yimtubezinash Woldeamanuel; Sofia Ny; Fredrik Westerlund; Abraham Aseffa; Christian G. Giske

Published: 2021

Published in: JAC-ANTIMICROBIAL RESISTANCE

Publication type: Journal article
Optical dna mapping of plasmids reveals clonal spread of carbapenem-resistant klebsiella pneumoniae in a large thai hospital

Author: Sriram Kesarimangalam; Tsegaye Sewunet; Walaiporn Wangchinda; Teerawit Tangkoskul; Visanu Thamlikitkul; Christian G. Giske; Fredrik Westerlund

Published: 2021

Published in: Antibiotics

Publication type: Journal article
Complex conformational dynamics of the heart failure‐associated pre‐mirna‐377 hairpin revealed by single‐molecule optical tweezers

Author: Anna Wiktoria Wypijewska Del Nogal; Vinoth Sundar Rajan; Fredrik Westerlund; Marcus Wilhelmsson

Published: 2021

Published in: International Journal of Molecular Sciences

Publication type: Journal article
C-terminal truncation of α-synuclein alters DNA structure from extension to compaction

Author: Kai Jiang; Sandra Rocha; Ranjeet Kumar; Fredrik Westerlund; Pernilla Wittung Stafshede

Published: 2021

Published in: Biochemical and Biophysical Research Communications

Publication type: Journal article
Mechanical characterization of base analogue modified nucleic acids by force spectroscopy

Author: Vinoth Sundar Rajan; Xavier Viader-Godoy; Yii Lih Lin; Uttama Dutta; Fredrik Westerlund; Marcus Wilhelmsson

Published: 2021

Published in: Physical Chemistry Chemical Physics

Publication type: Journal article
Identity of blactx-m carrying plasmids in sequential esbl-e. Coli isolates from patients with recurrent urinary tract infections

Author: N. Karami; Sriram Kesarimangalam; Shora Yazdanshenas; Yii Lih Lin; Daniel Jaén-Luchoro; Elina Ekedahl; Sanjana Parameshwaran; Anna Lindblom; Christina Åhrén; Fredrik Westerlund

Published: 2021

Published in: Microorganisms

Publication type: Journal article
Shining light on single-strand lesions caused by the chemotherapy drug bleomycin

Author: Vandana Singh; Pegah Johansson; Yii Lih Lin; Ola Hammarsten; Fredrik Westerlund

Published: 2021

Published in: DNA Repair

Publication type: Journal article
The HIV-1 nucleocapsid chaperone protein forms locally compacted globules on long double-stranded DNA

Author: Kai Jiang; Nicolas Humbert; Sriram Kesarimangalam; I. Rouzina; Yves Mely; Fredrik Westerlund

Published: 2021

Published in: Nucleic Acids Research

Publication type: Journal article
Single Molecule Experiments Define the Role of Nbs1 and Xrs2 in DNA Tethering by MRN and MRX in DSB Repair

Author: Carl Ivar Möller; Rajhans Sharma; Robin Öz; Giordano Reginato; Elda Cannavo; Sriram Kesarimangalam; Petr Cejka; Fredrik Westerlund

Published: 2021

Published in:

Publication type: Other conference contribution
Dynamics of Ku and bacterial non-homologous end-joining characterized using single DNA molecule analysis

Author: Robin Öz; Jing L. Wang; Raphael Guerois; Gaurav Goyal; Sriram Kesarimangalam; Virginie Ropars; Rajhans Sharma; Firat Koca; Jean Baptiste Charbonnier; M. Modesti; Terence R. Strick; Fredrik Westerlund

Published: 2021

Published in: Nucleic Acids Research

Publication type: Journal article
Polyphasic characterization of carbapenemresistant Klebsiella pneumoniae clinical isolates suggests vertical transmission of the blaKPC-3gene

Author: Catarina Ferreira; Santosh Kumar Bikarolla; Karolin Frykholm; Saga Pohjanen; Margarida Brito; Catarina Lameiras; O. C. Nunes; Fredrik Westerlund; C. M. Manaia

Published: 2021

Published in: PLoS ONE

Publication type: Journal article
2020
Optical maps of plasmids as a proxy for clonal spread of MDR bacteria: A case study of an outbreak in a rural Ethiopian hospital

Author: Yii Lih Lin; Tsegaye Sewunet; Sriram Kesarimangalam; Christian G. Giske; Fredrik Westerlund

Published: 2020

Published in: Journal of Antimicrobial Chemotherapy

Publication type: Journal article
Real-time compaction of nanoconfined DNA by an intrinsically disordered macromolecular counterion

Author: Rajhans Sharma; Sriram Kesarimangalam; Erik D. Holmstrom; Fredrik Westerlund

Published: 2020

Published in: Biochemical and Biophysical Research Communications

Publication type: Journal article
Quantifying DNA damage induced by ionizing radiation and hyperthermia using single DNA molecule imaging

Author: Vandana Singh; Pegah Johansson; Dmitry Torchinsky; Yii Lih Lin; Robin Öz; Y. Ebenstein; Ola Hammarsten; Fredrik Westerlund

Published: 2020

Published in: Translational Oncology

Publication type: Journal article
Molecular Epidemiology of OXA-48 and NDM-1 Producing Enterobacterales Species at a University Hospital in Tehran, Iran, Between 2015 and 2016

Author: Hamid Solgi; Shoeib Nematzadeh; Christian G. Giske; Farzad Badmasti; Fredrik Westerlund; Yii Lih Lin; Gaurav Goyal; Vajihe Sadat Nikbin; Amir Hesam Nemati; Fereshteh Shahcheraghi

Published: 2020

Published in: Frontiers in Microbiology

Publication type: Journal article
Lipid vesicle composition influences the incorporation and fluorescence properties of the lipophilic sulphonated carbocyanine dye SP-DiO

Author: Quentin Lubart; Jonas Hannestad; Hudson Pace; Daniel Fjällborg; Fredrik Westerlund; Elin Esbjörner Winters; Marta Bally

Published: 2020

Published in: Physical Chemistry Chemical Physics

Publication type: Journal article
Identifying Evolutionarily Conserved Features of NHEJ from Prokaryotes to Eukaryotes using Single-Molecule Approaches

Author: Robin Öz; Rajhans Sharma; Sriram Kesarimangalam; Fredrik Westerlund

Published: 2020

Published in:

Publication type: Other conference contribution

Go to Chalmers publication library

Projects
1/1/2020 — 12/31/2022

Förbättrad cancerbehandling av barn känsliga för DNA-skador
1/1/2020 — 12/31/2022

Förbättrad diagnos av akut leukemi hos barn
1/1/2020 — 12/31/2022

Identification of bacterial infections and antibiotic resistance in low income countries by rapid...
1/1/2021 — 12/31/2023

Identifying molecular mechanisms causing sensitivity to chemotherapy
4/1/2020 — 3/31/2025

Next Generation Nanofluidic Devices for Single Molecule Analysis of DNA Repair Dynamics
1/1/2021 — 12/31/2024

Real-Time Visualization of DNA Repair - One Molecule at a Time
Closed
1/1/2012 — 12/31/2015

A nanofluidic platform for single molecule biophysics
8/1/2017 — 7/31/2019

A novel ultrafast method for detecting multiresistant bacteria in intensive care units
12/1/2019 — 9/30/2020

Basal oxidative damage level assay (BODLA)
1/1/2017 — 12/31/2019

Bärbar diagnostik för sjukdom och antibiotikaresistans med fokus på malaria och bakterieinfektioner
11/1/2016 — 4/30/2018

Characterization of bacterial plasmids on a smartphone
8/24/2020 — 5/17/2021

Detection and characterization of chromosomal translocations in acute leukemia using optical DNA...
6/1/2015 — 12/31/2019

Genomic diagnostics beyond the sequence (BeyondSeq)
1/1/2018 — 12/31/2020

Individanpassning av cancerbehandling med cellgifter genom direkt mätning av DNA-skador
1/1/2017 — 12/31/2019

Mätning av DNA-skador som ett sätt att individanpassa cancerbehandling med cellgifter
1/1/2014 — 12/31/2016

Nanofluidics for ultrafast diagnosis of bacterial infections (NanoDiaBac)
1/1/2015 — 12/31/2016

Odlingsfri identifiering av antibiotikaresistens
4/1/2018 — 12/31/2020

Plasmididentifikation och -detektion i Sydostasien - Enterobacteriaceae resistenta mot sista...
7/1/2016 — 12/31/2018

Studier av DNA-reparation på enskilda DNA-molekyler

Page manager Published: Tue 01 Sep 2020.

Fredrik Westerlund

Latest publications

2022

2021

2020

Projects

Closed