Yun Chen

Senior Researcher, Systems Metabolic Engineering

yunc@chalmers.se +46317723140 Find me http://orcid.org/0000-0002-2146-6008

Yun Chen is a project leader at Systems and Synthetic Biology group. His research is centered on synthetic biology and metabolic engineering to develop efficient microbial cell factories for sustainable production of both fine chemicals such as isoprenoids that can be used as fragrance, and bulk chemicals such as 3-hydroxypropionic acid that can be used as feedstocks in the chemical industry for polymer production. He is involved in teaching masters course KKR063 Metabolic Engineering.

Publications
Collaboration and projects

Latest publications

2020
Multidimensional engineering of Saccharomyces cerevisiae for efficient synthesis of medium-chain fatty acids

Author: Zhu Zhiwei; Yating Hu; Paulo Teixeira; Rui Pereira; Yun Chen; Verena Siewers; Jens B Nielsen

Published: 2020

Published in: Nature Catalysis

Publication type: Journal article
2019
Metabolic engineering and transcriptomic analysis of Saccharomyces cerevisiae producing p-coumaric acid from xylose

Author: Gheorghe M. Borja; A. Rodriguez; Kate Campbell; I. Borodina; Yun Chen; Jens B Nielsen

Published: 2019

Published in: Microbial Cell Factories

Publication type: Journal article
Rewiring carbon metabolism in yeast for high level production of aromatic chemicals

Author: Quanli Liu; Tao Yu; Xiaowei Li; Yu Chen; Kate Campbell; Jens B Nielsen; Yun Chen

Published: 2019

Published in: Nature Communications

Publication type: Journal article
Adaptive laboratory evolution of tolerance to dicarboxylic acids in Saccharomyces cerevisiae

Author: Rui Pereira; Yongjun Wei; Elsayed Mohamed; Mohammad Radi; Carl Malina; M. J. Herrgard; Adam M. Feist; Jens B Nielsen; Yun Chen

Published: 2019

Published in: Metabolic Engineering

Publication type: Journal article
Expanding the Dynamic Range of a Transcription Factor-Based Biosensor in Saccharomyces cerevisiae

Author: Yasaman Dabirian; Xiaowei Li; Yun Chen; Florian David; Jens B Nielsen; Verena Siewers

Published: 2019

Published in: ACS Synthetic Biology

Publication type: Journal article
Effects of overexpression of STB5 in Saccharomyces cerevisiae on fatty acid biosynthesis, physiology and transcriptome

Author: Alexandra Linda Bergman; Dóra Vitay; John Hellgren; Yun Chen; Jens B Nielsen; Verena Siewers

Published: 2019

Published in: FEMS Yeast Research

Publication type: Journal article
Heterologous phosphoketolase expression redirects flux towards acetate, perturbs sugar phosphate pools and increases respiratory demand in Saccharomyces cerevisiae

Author: Alexandra Linda Bergman; John Hellgren; Thomas Moritz; Verena Siewers; Jens Christian Froslev Nielsen; Yun Chen

Published: 2019

Published in: Microbial Cell Factories

Publication type: Journal article
Harnessing xylose pathways for biofuels production

Author: Xiaowei Li; Yun Chen; Jens Christian Froslev Nielsen

Published: 2019

Published in: Current Opinion in Biotechnology

Publication type: Review article
Lipid engineering combined with systematic metabolic engineering of Saccharomyces cerevisiae for high-yield production of lycopene

Author: Tian Ma; Bin Shi; Ziling Ye; Xiaowei Li; Min Liu; Yun Chen; Jiang Xia; Jens Christian Froslev Nielsen; Zixin Deng; Tiangang Liu

Published: 2019

Published in: Metabolic Engineering

Publication type: Journal article
2018
Modular Pathway Rewiring of Yeast for Amino Acid Production

Author: Quanli Liu; Tao Yu; Kate Campbell; Jens Christian Froslev Nielsen; Yun Chen

Published: 2018

Published in:

Publication type: Book chapter
Global rewiring of cellular metabolism renders Saccharomyces cerevisiae Crabtree negative

Author: Zongijie Dai; Mingtao Huang; Yun Chen; Verena Siewers; Jens B Nielsen

Published: 2018

Published in: Nature Communications

Publication type: Journal article
2017
Comparison of the metabolic response to over-production of p-coumaric acid in two yeast strains

Author: A. Rodriguez; Yun Chen; Sakda Khoomrung; E. Ozdemir; I. Borodina; Jens B Nielsen

Published: 2017

Published in: Metabolic Engineering

Publication type: Journal article
Elimination of the last reactions in ergosterol biosynthesis alters the resistance of Saccharomyces cerevisiae to multiple stresses

Author: Guodong Liu; Yun Chen; N. J. Faergeman; Jens B Nielsen

Published: 2017

Published in: FEMS Yeast Research

Publication type: Journal article
Effects of acetoacetyl-CoA synthase expression on production of farnesene in Saccharomyces cerevisiae

Author: Stefan Tippmann; Raphael Ferreira; Verena Siewers; Jens B Nielsen; Yun Chen

Published: 2017

Published in: Journal of Industrial Microbiology and Biotechnology

Publication type: Journal article
2016
Engineering and systems-level analysis of Saccharomyces cerevisiae for production of 3-hydroxypropionic acid via malonyl-CoA reductase-dependent pathway

Author: K. R. Kildegaard; N. B. Jensen; K. Schneider; E. Czarnotta; E. Ozdemir; T. Klein; J. Maury; B. E. Ebert; H. B. Christensen; Yun Chen; Il-Kwon Kim; M. J. Herrgard; L. M. Blank; J. Forster; Jens B Nielsen; I. Borodina

Published: 2016

Published in: Microbial Cell Factories

Publication type: Journal article
Biobased organic acids production by metabolically engineered microorganisms

Author: Yun Chen; Jens B Nielsen

Published: 2016

Published in: Current Opinion in Biotechnology

Publication type: Journal article
Thermotolerant yeasts selected by adaptive evolution express heat stress response at 30 degrees C

Author: Luis Caspeta-Guadarrama; Yun Chen; Jens B Nielsen

Published: 2016

Published in: Scientific Reports

Publication type: Journal article
Functional expression and evaluation of heterologous phosphoketolases in Saccharomyces cerevisiae

Author: Alexandra Linda Bergman; Verena Siewers; Jens B Nielsen; Yun Chen

Published: 2016

Published in: AMB Express

Publication type: Journal article
2015
Functional pyruvate formate lyase pathway expressed with two different electron donors in Saccharomyces cerevisiae at aerobic growth

Author: Yiming Zhang; Zongijie Dai; Anastasia Krivoruchko; Yun Chen; Verena Siewers; Jens B Nielsen

Published: 2015

Published in: FEMS Yeast Research

Publication type: Journal article
Adaptive mutations in sugar metabolism restore growth on glucose in a pyruvate decarboxylase negative yeast strain

Author: Yiming Zhang; Guodong Liu; Martin Engqvist; Anastasia Krivoruchko; B. M. Hallstrom; Yun Chen; Verena Siewers; Jens B Nielsen

Published: 2015

Published in: Microbial Cell Factories

Publication type: Journal article
Enabling Technologies to Advance Microbial Isoprenoid Production

Author: Yun Chen; Yongjin Zhou; Verena Siewers; Jens B Nielsen

Published: 2015

Published in: Advances in Biochemical Engineering/Biotechnology

Publication type: Journal article
De novo production of resveratrol from glucose or ethanol by engineered Saccharomyces cerevisiae

Author: M. Li; K. R. Kildegaard; Yun Chen; A. Rodriguez; I. Borodina; Jens B Nielsen

Published: 2015

Published in: Metabolic Engineering

Publication type: Journal article
Microbial acetyl-CoA metabolism and metabolic engineering

Author: Anastasia Krivoruchko; Yiming Zhang; Verena Siewers; Yun Chen; Jens B Nielsen

Published: 2015

Published in: Metabolic Engineering

Publication type: Journal article
Production of 3-hydroxypropionic acid from glucose and xylose by metabolically engineered Saccharomyces cerevisiae

Author: K. R. Kildegaard; Zheng Wang; Yun Chen; Jens B Nielsen; I. Borodina

Published: 2015

Published in: Metabolic Engineering Communications

Publication type: Journal article
Ach1 is involved in shuttling mitochondrial acetyl units for cytosolic C2 provision in Saccharomyces cerevisiae lacking pyruvate decarboxylase

Author: Yun Chen; Yiming Zhang; Verena Siewers; Jens B Nielsen

Published: 2015

Published in: FEMS Yeast Research

Publication type: Journal article

Go to Chalmers publication library

Projects
1/1/2019 — 12/31/2021

Systems metabolic engineering of yeast for production of flavonoids
Closed
7/1/2017 — 9/30/2019

Biosynthesis of the high-value plant secondary metabolites in yeast
6/5/2013 — 6/30/2016

Design and Assembly of Novel Pathways for Advanced Biofuel Synthesis
1/1/2016 — 12/31/2019

Engineering xylose metabolism for multiple products
1/1/2016 — 12/31/2019

Manipulering av xylos metabolism för tillverkning av flertal produkter
1/1/2016 — 12/31/2017

Synthetic biochemical pathways for efficient conversion of xylose into renewable biofuels and...

Published: Wed 26 Jun 2019.

Yun Chen

Latest publications

2020

2019

2018

2017

2016

2015

Projects

Closed