Yun Chen

Senior Researcher, Systems Metabolic Engineering

yunc@chalmers.se +46317723140 Find me http://orcid.org/0000-0002-2146-6008

Yun Chen is a project leader at Systems and Synthetic Biology group. His research is centered on synthetic biology and metabolic engineering to develop efficient microbial cell factories for sustainable production of both fine chemicals such as isoprenoids that can be used as fragrance, and bulk chemicals such as 3-hydroxypropionic acid that can be used as feedstocks in the chemical industry for polymer production. He is involved in teaching masters course KKR063 Metabolic Engineering.

Publications
Collaboration and projects

Latest publications

2022
Catalytic promiscuity of O-methyltransferases from Corydalis yanhusuo leading to the structural diversity of benzylisoquinoline alkaloids

Author: Junling Bu; Xiuhua Zhang; Qishuang Li; Ying Ma; Zhimin Hu; Jian Yang; Xiuyu Liu; Ruishan Wang; Xiang Jiao; Tong Chen; Changjiangsheng Lai; Guanghong Cui; Jinfu Tang; Yu Kong; Lei Yang; Sheng Lin; Yun Chen; Juan Guo; Luqi Huang

Published: 2022

Published in: Horticulture Research

Publication type: Journal article
Optimization of Pinocembrin Biosynthesis in Saccharomyces cerevisiae

Author: Marta Tous Mohedano; Jiwei Mao; Yun Chen

Published: 2022

Published in: ACS Synthetic Biology

Publication type: Journal article
Metabolic reconfiguration enables synthetic reductive metabolism in yeast

Author: Tao Yu; Quanli Liu; Xiang Wang; Xiangjian Liu; Yun Chen; Jens B Nielsen

Published: 2022

Published in: Nature Metabolism

Publication type: Journal article
Editorial: Genomic strategies for efficient microbial cell factories

Author: Eugene Fletcher; Yun Chen; Luis Caspeta-Guadarrama; Amir Feizi

Published: 2022

Published in: Frontiers in Bioengineering and Biotechnology

Publication type: Other text in scientific journal
Strategies to increase tolerance and robustness of industrial microorganisms

Author: Marta Tous Mohedano; Oliver Konzock; Yun Chen

Published: 2022

Published in: Synthetic and Systems Biotechnology

Publication type: Journal article
2021
Functional characterization of (S)–N-methylcoclaurine 3′-hydroxylase (NMCH) involved in the biosynthesis of benzylisoquinoline alkaloids in Corydalis yanhusuo

Author: Xiuyu Liu; Junling Bu; Ying Ma; Yun Chen; Qishuang Li; Xiang Jiao; Zhimin Hu; Guanghong Cui; Jinfu Tang; Juan Guo; Luqi Huang

Published: 2021

Published in: Plant Physiology and Biochemistry

Publication type: Journal article
De novo biosynthesis of bioactive isoflavonoids by engineered yeast cell factories

Author: Quanli Liu; Yi Liu; Gang Li; Otto Savolainen; Yun Chen; Jens B Nielsen

Published: 2021

Published in: Nature Communications

Publication type: Journal article
Metabolic network remodelling enhances yeast’s fitness on xylose using aerobic glycolysis

Author: Xiaowei Li; Yanyan Wang; Gang Li; Quanli Liu; Rui Pereira; Yun Chen; Jens B Nielsen

Published: 2021

Published in: Nature Catalysis

Publication type: Journal article
Strategies and challenges with the microbial conversion of methanol to high-value chemicals

Author: Chunjun Zhan; Xiaowei Li; Yankun Yang; Jens B Nielsen; Zhonghu Bai; Yun Chen

Published: 2021

Published in: Biotechnology and Bioengineering

Publication type: Review article
Yeast optimizes metal utilization based on metabolic network and enzyme kinetics

Author: Yu Chen; Feiran Li; Jiwei Mao; Yun Chen; Jens B Nielsen

Published: 2021

Published in: Proceedings of the National Academy of Sciences of the United States of America

Publication type: Journal article
2020
Rewiring Central Carbon Metabolism Ensures Increased Provision of Acetyl-CoA and NADPH Required for 3-OH-Propionic Acid Production

Author: Ning Qin; Lingyun Li; Xu Ji; Xiaowei Li; Yiming Zhang; Christer Larsson; Yun Chen; Jens B Nielsen; Zihe Liu

Published: 2020

Published in: ACS Synthetic Biology

Publication type: Journal article
Elucidating aromatic acid tolerance at low pH in Saccharomyces cerevisiae using adaptive laboratory evolution

Author: Rui Pereira; Elsayed Mohamed; Mohammad Radi; M. J. Herrgard; Adam M. Feist; Jens B Nielsen; Yun Chen

Published: 2020

Published in: Proceedings of the National Academy of Sciences of the United States of America

Publication type: Journal article
Third-generation biorefineries as the means to produce fuels and chemicals from CO2

Author: Zihe Liu; Kai Wang; Yun Chen; Tianwei Tan; Jens B Nielsen

Published: 2020

Published in: NATURE CATALYSIS

Publication type: Review article
Current state of aromatics production using yeast: achievements and challenges

Author: Quanli Liu; Yi Liu; Yun Chen; Jens B Nielsen

Published: 2020

Published in: Current Opinion in Biotechnology

Publication type: Review article
Multidimensional engineering of Saccharomyces cerevisiae for efficient synthesis of medium-chain fatty acids

Author: Zhu Zhiwei; Yating Hu; Paulo Teixeira; Rui Pereira; Yun Chen; Verena Siewers; Jens B Nielsen

Published: 2020

Published in: Nature Catalysis

Publication type: Journal article
2019
Metabolic engineering and transcriptomic analysis of Saccharomyces cerevisiae producing p-coumaric acid from xylose

Author: Gheorghe M. Borja; A. Rodriguez; Kate Campbell; I. Borodina; Yun Chen; Jens B Nielsen

Published: 2019

Published in: Microbial Cell Factories

Publication type: Journal article
Rewiring carbon metabolism in yeast for high level production of aromatic chemicals

Author: Quanli Liu; Tao Yu; Xiaowei Li; Yu Chen; Kate Campbell; Jens B Nielsen; Yun Chen

Published: 2019

Published in: Nature Communications

Publication type: Journal article
Adaptive laboratory evolution of tolerance to dicarboxylic acids in Saccharomyces cerevisiae

Author: Rui Pereira; Yongjun Wei; Elsayed Mohamed; Mohammad Radi; Carl Malina; M. J. Herrgard; Adam M. Feist; Jens B Nielsen; Yun Chen

Published: 2019

Published in: Metabolic Engineering

Publication type: Journal article
Expanding the Dynamic Range of a Transcription Factor-Based Biosensor in Saccharomyces cerevisiae

Author: Yasaman Dabirian; Xiaowei Li; Yun Chen; Florian David; Jens B Nielsen; Verena Siewers

Published: 2019

Published in: ACS Synthetic Biology

Publication type: Journal article
Effects of overexpression of STB5 in Saccharomyces cerevisiae on fatty acid biosynthesis, physiology and transcriptome

Author: Alexandra Linda Bergman; Dóra Vitay; John Hellgren; Yun Chen; Jens B Nielsen; Verena Siewers

Published: 2019

Published in: FEMS Yeast Research

Publication type: Journal article
Heterologous phosphoketolase expression redirects flux towards acetate, perturbs sugar phosphate pools and increases respiratory demand in Saccharomyces cerevisiae

Author: Alexandra Linda Bergman; John Hellgren; Thomas Moritz; Verena Siewers; Jens Christian Froslev Nielsen; Yun Chen

Published: 2019

Published in: Microbial Cell Factories

Publication type: Journal article
Harnessing xylose pathways for biofuels production

Author: Xiaowei Li; Yun Chen; Jens Christian Froslev Nielsen

Published: 2019

Published in: Current Opinion in Biotechnology

Publication type: Review article
Lipid engineering combined with systematic metabolic engineering of Saccharomyces cerevisiae for high-yield production of lycopene

Author: Tian Ma; Bin Shi; Ziling Ye; Xiaowei Li; Min Liu; Yun Chen; Jiang Xia; Jens Christian Froslev Nielsen; Zixin Deng; Tiangang Liu

Published: 2019

Published in: Metabolic Engineering

Publication type: Journal article
2018
Modular Pathway Rewiring of Yeast for Amino Acid Production

Author: Quanli Liu; Tao Yu; Kate Campbell; Jens Christian Froslev Nielsen; Yun Chen

Published: 2018

Published in: Methods in Enzymology

Publication type: Book chapter
Global rewiring of cellular metabolism renders Saccharomyces cerevisiae Crabtree negative

Author: Zongijie Dai; Mingtao Huang; Yun Chen; Verena Siewers; Jens B Nielsen

Published: 2018

Published in: Nature Communications

Publication type: Journal article

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Projects
1/1/2023 — 12/31/2025

Direct fermentation route for sustainable plastics and superabsorbent polymers
4/1/2020 — 12/31/2023

Microbial synthesis of medicinal natural products
Closed
7/1/2017 — 9/30/2019

Biosynthesis of the high-value plant secondary metabolites in yeast
6/5/2013 — 6/30/2016

Design and Assembly of Novel Pathways for Advanced Biofuel Synthesis
1/1/2016 — 12/31/2019

Engineering xylose metabolism for multiple products
1/1/2016 — 12/31/2019

Manipulering av xylos metabolism för tillverkning av flertal produkter
1/1/2019 — 12/31/2021

Production of Benzylisoquinoline Alkaloids in Yeast
1/1/2016 — 12/31/2017

Synthetic biochemical pathways for efficient conversion of xylose into renewable biofuels and...
1/1/2019 — 12/31/2021

Systems metabolic engineering of yeast for production of flavonoids

Page manager Published: Tue 13 Dec 2022.

Yun Chen

Latest publications

2022

2021

2020

2019

2018

Projects

Closed