Design of bioactive and bodyabsorbable implants


GOAL & AIM
The goal of this project is to design bioactive implants with tailor-made drug release profiles. To achieve this we use different techniques to include drugs into biodegradable polymers, and we fabricate implants of different structures and geometries like foams, films, rods and coatings.

BACKGROUND
We come across medical implants and medical devices in our everyday life – to help us hear, to help us chew our food, to mend a broken bone or to prevent a pregnancy. In many ways implants improve the quality of life. The implants may aid bone healing and correct teeth defects, give local controlled drug delivery or be used in cosmetic surgery, just to mention a few of many applications.

Implants can be temporary placed during a healing process and are then removed surgically. The benefits in time, pain and cost reduction of using implants that are resorbed and degraded in the body, and then leaves the body through the natural routes are obvious.
Another benefit is that the drugs may be directly incorporated into the resorbable implant, giving faster healing.  The challenge is to design tailor maid bioactive implants where the polymer material control the release of the drugs to give the desired biological effect.

RESEARCH QUESTIONS

  • How should we design a material structure to give the best drug release and material degradation?
  • Can we locally stimulate cells in order to improve the healing and regulate the bone growth at fracture sites using resorbable implants?
  • How can we use techniques like hot melt extrusion to improve the distribution of the drug in the bioactive implant and to achieve the desired drug release profile?

Published: Wed 17 Apr 2013. Modified: Mon 28 Oct 2013