Physics and chemistry of nucleic acids

  • Course code: FKBT020
  • Course higher education credits: 7.5
  • Department: CHEMISTRY AND CHEMICAL ENGINEERING
  • Graduate school: Bioscience
  • Course is normally given: Every third year
  • Language: The course will be given in English
DNA, regarding structure, dynamics and interactions in solution. It is a literature course where each participant gives a presentation (2h) of a chapter of the book. Examination is through 1) the oral presentation, 2) weekly assignments dealing with each lecture, and 3) a few broader assignments at the end of the course.

Nitrogen bases, nucleosides, nucleotides. Chemical and enzymatic methods, Sequencing. DNA structure. UV-vis and IR spectroscopy. Theoretical methods. Size and shape of DNA coils. Conformational change. Circular DNA. Interactions with water, ions, dyes, drugs and proteins. Coil-compaction in vitro and packaging in bacteriophages.

Application information
Application is made by sending an email to Björn Åkerman
Literature
Nucleic Acids. Structures, Properties and Functions.
Bloomfield, V.A., Crothers, D.M., and Tinoco, I.
University Science Books, Sausalito 2000
Lecturers
Björn Åkerman
More information
Björn Åkerman, email: baa@chalmers.se , phone: +46 (0)31 772 30 52 Office: Room 5066, Department of Chemical and Biological Engineering, Physical Chemistry, Kemivägen 10

 

Published: Fri 14 Dec 2012. Modified: Thu 20 Feb 2014