Pharmaceutical Technology

 

Pharmaceutical technology was established as a scientific discipline at Chalmers in 2001 in conjunction with the commencement of the pharmacist and dispensing pharmacist undergraduate programmes in Gothenburg.

 



Research is oriented towards the use of lipids and polymers in pharmaceutical formulations and other biotechnical applications. Of particular interest are lipid formulations intended for use on skin, in particular the transport of active substances through the skin. Another area of research is the utilisation of polymers (modified celluloses and polyethyleneglycols (PEG) to achieve extended release of drugs of different polarity. In a third project, cubic and sponge lipid phases are used to facilitate the crystallisation of membrane proteins. In all projects the focus is on characterisation of systems on a molecular and colloidal level in order to increase the understanding of the function of the chemical systems. 

Contact:   Anette Larsson and  Sven Engström

 

Contact:  Dr Anna Bergstrand and  Professor Anette Larsson
Project summary: The goal of this project is to design bioactive implants with tailor-made drug release profiles. Different techniques are employed to include drugs into biodegradable polymers, and the implants are fabricated using different structures and geometries like foams, films, rods and coatings.

New ideas for more effective drug manufacturing
Contact:  Magnus Svensson and Professor Anette Larsson
Project summary: In this project the hot-melt extrusion manufacturing process is refined  to suite a wide variety of drugs. The gain of a one-step continuous process for drug production will reduce costs, save time and benefit the environment.

Developing barrier coatings with cellulose derivatives
Contact: Helene Andersson, Professor Mats Stading, SIK, and Professor Anette Larsson .
Project summary: This project is founded by the VINN Excellence Centre SuMo Biomaterials. This project aim to design coatings with controlled barrier properties, by controlling the structure development. We develop knowledge on novel barriers from natural resources, with applications ranging from foods and packaging to medical devices and pharmaceutics. 
 
Diffusion within and through interfaces
Contact: Sofie Gårdebjer, Professor Anette Larsson and Dr Niklas Lorén .
Project summary: This project is founded by the VINN Excellence Centre SuMo Biomaterials. The project aim to predict the diffusion for different molecules based on the knowledge of the structure of the interface in order to design new materials with controllable diffusion properties. 
 
Targeted delivery of nanoparticles using short peptides
Contact: Associate Professor Carl-Gustav  Sigfridsson
Project summary: This project is performed at AstraZeneca R&D Mölndal, Sweden. The project aims to develop drug nanoparticles linked to peptide carriers to directly target diseases. The sequences of the peptides, the effect of nanoparticle coating and the effect of stabilizers are studied. The gain of using targeted nanoparticles are to reduce side effects and reduce health care costs.
 
Drug delivery through skin using cubic delivery systems
Contact: Hanne Evenbratt ,  Associate Professor Marica Ericson, GU, and Professor Sven Engström
Project summary: This project is founded by VR and performed in cooperation with Center for Skin Research. This projects aim to develop an effective dermal drug delivery vehicle based on a cubic lipd-water formulation for small and large molecules. Through understanding the diffusion of formulation and drugs into the skin the project investigates more effective skin cancer therapy and the transport of large biomolecules and nanoparticles across skin.

Published: Fri 14 Dec 2012. Modified: Mon 26 May 2014