Guest lecture: Knowledge based design of lipase B from Candida antarctica

​​Speaker: Professor Karl Hult, School of Biotechnology, KTH, Stockholm

Lipase B from Candida antarctica is active in many organic solvents. It has been used a lot in organic synthesis and is an important industrial catalyst. With different examples I will show how we designed the enzyme to change enantioselectivity and substrate selectivity. A more challenging task has been to approach catalytic promiscuity. By using parts of the catalytic machinery we have introduced new reactions catalyzed by a lipase, such as aldol condensation and Michael additions.

Contact information
Christian Thörn
Industriell bioteknik
+46 31 772 38 43
Category Seminar
Location: Chemistry building, Room 10'an, Kemivägen 10, Campus Johanneberg
Starts: 28 January, 2013, 15:00
Ends: 28 January, 2013, 16:00

Published: Fri 25 Jan 2013.