Jagannath Kuchlyan

Post Doc, Department of Chemistry and Chemical Engineering, Division of Chemistry and Biochemistry, Wilhelmsson group

Dr. Jagannath Kuchlyan joined the Wilhelmsson research group as a postdoc in 2021. His research interest is on nucleic acid structure, function, and dynamics. In his research he applies spectroscopy and microscopy-based techniques to investigate conformational dynamics of nucleic acids and cellular uptake and distribution of RNA-based therapeutics. He develops, characterizes and utilizes fluorescent base analogues which have a minimal perturbing effect on the nucleic acid structure and properties.. One of the main aims of his research is to design and utilize fluorescent molecules for oligonucleotide diagnostic, assay and therapeutic application.
​1. A. Tavakoli, D. Paul, H. Mu, J. Kuchlyan, S. Baral, A. Ansari, S. Broyde and J-H Min. Light-induced modulation of DNA recognition by the Rad4/XPC damage sensor protein. RSC Chem. Biol. 2021, 2, 523−536. 
2. J. Kuchlyan, L. Martinez-Fernandez, M. Mori, K. Gavvala, S. Ciaco, C. Boudier, L. Richert, P. Didier, Y. Tor, R. Improta, and Y. Mély. What makes thienoguanosine an outstanding fluorescent DNA probe? J. Am. Chem. Soc. 2020, 142, 16999−17014. 
3. P. Didier, J. Kuchlyan, L. Martinez-Fernandez, P. Gosset, J. Le´onard, Y. Tor, R. Improta, and Y. Mély. Deciphering the pH-dependence of ground-and excited-state equilibria of thienoguanine. Phys. Chem. Chem. Phys. 2020, 22, 7381–739.​

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