PhD, Department of Chemical and Biological Engineering, Chalmers University of Technology May 2004
Post-doc, Chalmers University of Technology, May 2004 – Dec 2005
Post-doc, University of Florida, Jan 2006 – Dec 2007
Assistant professor in Nanochemistry at Chalmers University of Technology, Jan 2008-
Research
Formation of nanosized materials using surfactant self-assembly
The main objective of this part of my research is to study how surfactant assemblies can be used as templates to form various types of inorganic nanomaterials. Formation of nano-structured silver, titanium oxide, calcium carbonate and hydroxyapatite has been performed. A major part of the research is focused on how surfactants influence the morphology and crystallinity of the formed materials. Moreover, the effect on the surfactants themselves is investigated to some extent.
Photocatalysis
The use of wide band-gap semiconductors, especially titania, as photocatalysts to clean air and water is an attractive method because the catalyst is efficient, non-toxic and of relatively low cost. The catalytic activity has been proven to be dependent on the particle size and crystallinity. As part of my work in this area of research, nanoparticles of both anatase and rutile titania, and mesoporous titania have been photocatalytically evaluated.
Bioactive hydroxyapatite
Hard tissue nano engineering, such as the formation of hydroxyapatite (HA) nanoparticles, is a part of research that is of high interest since many biological processes concern reactions or interactions with entities of nanometer size. The characteristics of the nanomaterial, such as morphology, crystallinity, and size, have a great influence on the biological response, which makes it of importance to have preparation techniques where these properties are easily controllable. Within this research, hydroxyapatite are being synthesized utilizing surfactant self-assembly by which it is possible to control the above given parameters on a nanoscale. The biological response of these new materials is being evaluated by both in vitro and in vivo studies, where the different material parameters were independently varied. The results have given important insight into the mechanisms of the biological response as well as knowledge of how to more effectively introduce implants into living tissue. In order to study the interactions between these bioactive nanomaterials and living tissue, knowledge concerning both the material characteristics and the nature of biological substances is of importance. To meet these demands this research has been a collaboration between the Division of Applied Surface Chemistry, Chalmers and the Department of Prosthetic Dentistry, Sahlgrenska Academy at Göteborg University. The research has also resulted in a new company; Promimic AB.
Bio sensors using ion channels
Ion channels are transmembrane proteins that regulate the transport of ions and/or small molecules across the lipid membrane. They are highly suitable for sensor applications and there is an intense research effort to obtain stable micron sized devices utilizing them. Since ion-channel gating is a distinct and rapid event it is suitable for digitization and fast data handling. However, engineering of such devices demands stability, high reproducibility, and relatively long life times. A critical issue to overcome is the low stability of the ion channel environment, the bilayer membrane, and factors to consider include mechanical movement and chemical degradation.A promising technique to surmount this is to connect the lower part of the membrane to a surface forming a tethered bilayer membrane (tBLM). I have been part of the development of a novel methodology of employing a tBLM linked to a gold surface being a part of a microelectrode array device. The tBLM has been proven to have a very high stability, with life times of several hours, which together with high electrical resistance result in high signal to noise ratios allowing for single ion channel detection. This is the first time single ion channel events have been presented for ion channels located in a tethered bilayer membrane. Different types of ion channels have been investigated, including mechanosensitive high conducting MscL channels, analyte gating ion channels such as M2δ and Maxi K, as well as Gramicidin A.
Entrepreneurship
I am co founder of Promimic AB (2004), together with Per Kjellin. Promimic is a Swedish biomaterial company working with new generations of implant modifications and synthetic bone. Promimic has one product on the market, a bio sensor that can be used for studying the interaction between molecules and bone, developed in collaboration with Q-sense AB. Promimic is based in Gothenburg, Sweden, has six full time employees and is financed by both costumers and venture capital (Chalmers Innovation, Vinnova, Nutek, Teknikbrostiftelsen, and Karolinska Development). For more information about Promimic please visit: www.promimic.se.
Research funded by
The Swedish Research Council (VR)
The Knut and Alice Wallenberg Foundation
Vinnova
Awards
The Akzo Nobel Nordic Prize in Surface and Colloid Chemistry, 2006
Vinnu, given by Vinnova and Nutek, 2005
List of publications (2002-2008)
Peer-reviewed accepted articles
1. Precipitation of calcium phosphate in the presence of albumin on titanium implants with four different possibly bioactive surface preparations. An in vitro study
Stenport V., Kjellin P., Andersson M., Currie F., Sul Y.T., Wennerberg A. and Arvidsson A.
J. Mater. Sci., Materials in Medicine, 2008, 19 (12), 3497-3503
2. Use of self-assembled surfactants for nanomaterials synthesis
Martin Andersson, Anders E.C. Palmqvist and Krister Holmberg
Particulate Systems in Nan- and Biotechnologies 2008 CRS Press, ISBN:9780849374364
3. Studies on the formation of organosilica nanoparticles and their ability to host hydrophobic substances
Stjerndahl M., Jarvoll P., Andersson M., Kohout R. and Duran R.S.
J. Phys. Chem. C, 2008, 112 (44), 17063-17070
4. Prolonged stochastic single ion channel recordings in s-layer protein stabilized lipid bilayer membranes.
Henk M. Keizer, Martin Andersson, Chris Chase, William P. Laratta, Josh B. Proemsey, Joel Tabb, Joanna R Long, and Randolph S. Duran
6. Nano hydroxyapatite structures influence early bone formation.
Meirelles L, Arvidsson A, Andersson M., Kjellin P., Albrektsson T., Wennerberg A
J. Biomed. Mater. Res. A, 2008, 87A (2), 299-307
7. Bone reaction to nano hydroxyapatite modified titanium implants placed in a gap healing model
Meirelles L, Albrektsson T, Kjellin P, Arvidsson A, Stenport, V, Andersson M, Albrektsson T, Wennerberg A.
J. Biomed. Mater. Res. A. 2008 Volume 87A (3), 624 – 631
8. Superparamagnetic Fe3O4/SiO2 nanocomposites; a synthesis enabling the tuning of both the Fe load and the size of the nanoparticles
Maria Stjerndahl, Martin Andersson, Holly Hall, Daniel Pajerowski, Mark W. Meisel, and Randy Duran
Langmuir, 2008, 24 (7), 3532-3536
9. Voltage induced gating of the mechanosensitive MscL ion channel reconstituted in a tethered lipid bilayer membrane
Martin Andersson, George Okeyo, Danyell Wilson, Henk Keizer, Paul Moe, Paul Blount, Daniel Fine, Ananth Dodabalapur and Randolph S. Duran
Biosens. Bioelectron., 2008, 23 (6), 919-923
10. Using optical tweezers for measuring the interaction forces between human bone cells and implant surfaces: system design and force calibration
Martin Andersson, Maria Stjerndahl, Ashwin Madgavkar, Yanrong Wu, Weihong Tan and Randy Duran
Rev. Sci. Instrum., 2007, 78 (7), 074302
11. Functional ion channels in tethered bilayer membrane arrays; implications for biosensors
Henk M. Keizer, Brian R. Dorvel, Martin Andersson, Daniel Fine, Rebecca B. Price, Joanna R.Long, Ananth Dodabalapur, Ingo Köper, Wolfgang Knoll, Peter A. V. Anderson and Randolph S. Duran
ChemBioChem, 2007, 8 (11), 1246-1250
12. Microemulsion-mediated room temperature synthesis of high surface area rutile and its photocatalytic performance
M. Andersson, A. Kiselev, L. Österlund, and A.E.C. Palmqvist
J. Phys. Chem. C, 2007, 111 (18), 6789 -6797
13. Detection of single ion channel activity on a chip using tethered bilayer membranes
Andersson, M.; Keizer, H. M.; Zhu, C.; Fine, D.; Dodabalapur, A.; Duran, R. S.
Langmuir, 2007, 23(6), 2924-2927
14. Differences in catalytic properties between mesoporous and nanoparticulate platinum
A. Saramat, M. Andersson, S. Hant, P. Thormählen, M. Skoglundh, G.S. Attard, A.E.C. Palmqvist
European Physical Journal D, 2007, 43 (1-3), 209-211
15. Formation of calcium phosphates on titanium implants with four different bioactive surface preparations. An in vitro study.
Arvidsson A, Franke-Stenport V, Andersson M, Kjellin P, Sul Y-T, Wennerberg A.
J. Mater. Sci., Materials in Medicine, 2007, 18 (10), 1945-1954
16. Adsorption and photocatalytic degradation of DFP and DMMP over dry and humidified rutile TiO2
Kiselev, A. Mattson, M. Andersson, A. Palmqvist, and L. Österlund
J. Photochem. Photobiol. A, 2006, 184 (1-2), 125-134
17. Solar light decomposition of DFP on the surface of anatase and rutile TiO2 prepared by hydrothermal treatment of microemulsions
Kiselev, M. Andersson, A. Mattson, A. Shchukarev, S. Sjöberg, A. Palmqvist, and L. Österlund
Surface Science, 2005, 584 (1), 98-105
18. Kinetics of silver nanoparticle formation in microemulsions acting both as template and reducing agent
Martin Andersson, Jan Skov Pedersen and Anders E.C. Palmqvist
Langmuir, 2005, 21 (24), 11387-11396
19. Mesoporous titania with incorporated silver nanoparticles and its photocatalytic activity
Martin Andersson, Henrik Birkdal, Nathan Franklin, Tod Ostomel, Shannon Buecher, Anders E.C. Palmqvist and Galen Stucky
Chemistry of Materials, 2005, 17 (6), 1409-1415
20. The binary phase behavior of short-chain PDMS-b-PEO diblock copolymers in aqueous solutions in dependence of the PDMS chainlength - a combined polarized optical microscopy, 2H NMR and SAXS study
Guido Kickelbick, Josef Bauer, Nicola Hüsing, Martin Andersson and Krister Holmberg
Colloids and Surfaces A., 2005, 254(1-3), 37-48
21. Oxidation of self-organized nonionic surfactants
Fredrik Currie, Martin Andersson and Krister Holmberg
Langmuir, 2004, 20 (10), 3835-3837
22. Formation of calcium carbonate in liquid crystalline phases
Per Kjellin, Martin Andersson and Anders E.C. Palmqvist
Langmuir. 2003, 19 (22), 9196-9200
23.Small particles of a heparin/chitosan complex prepared from a pharmaceutically acceptable microemulsion
Guido Kickelbick, Josef Bauer, Nicola Hüsing, Martin Andersson and Anders Palmqvist
Langmuir 2003, 19 (8), 3198-3201
25. Aggregation behavior of short-chain PDMS-b-PEO diblock copolymers in aqueous solutions
Guido Kickelbick, Josef Bauer, Nicola Hüsing, Martin Andersson and Krister Holmberg
Langmuir 2003, 19 (24), 10073-10076
26. Use of self-assembling surfactants as templates and reactants for the synthesis of noble metal particles
Martin Andersson, Hanna Härelind Ingelsten, Anders E.C. Palmqvist, Magnus Skoglund and Krister Holmberg
Self-assembly, Brian H. Robinson (Ed.) IOS Press, 2003, 105-111
27. Preparation of nanosize anatase and rutile TiO2 by hydrothermal treatment of microemulsions and their activity for photocatalytic wet oxidation of phenol
Martin Andersson, Lars Österlund, Sten Ljungström and Anders Palmqvist
J. Phys. Chem. B, 2002, 106 (41), 10674-10679
28. Macroscopic alignment of silver nanoparticles in reverse hexagonal liquid crystalline templates
Martin Andersson, Viveka Alfredsson, Per Kjellin and Anders Palmqvist
Nano Letters, 2002, 2 (12), 1403-1407
Patents
29. Formation of nanocrystalline hydroxyapatite and its use as coating
Per Kjellin and Martin Andersson
Swedish Patent application 0401524-4 + applications in 9 other countries
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